Early adoption of pharmacogenetic testing for veterans prescribed psychotropic medications [0.03%]
退伍军人使用精神活性药物的药理基因检测的早期采用
Leland E Hull,Catherine Chanfreau-Coffinier,Sony Tuteja et al.
Leland E Hull et al.
Aim: Describe the characteristics of providers ordering, patients receiving, and clinical impact of a psychotropic pharmacogenetic test on veteran care. Patients & methods: Observational cohort study linking veterans' laboratory results to ...
Early adoption of pharmacogenetic testing for veterans prescribed psychotropic medications [0.03%]
退役军人开具 psychotropic 药物处方后早期采用药物基因组学检测
Leland E Hull,Catherine Chanfreau-Coffinier,Sony Tuteja et al.
Leland E Hull et al.
Aim: Describe the characteristics of providers ordering, patients receiving, and clinical impact of a psychotropic pharmacogenetic test on veteran care. Patients & methods: Observational cohort study linking veterans' laboratory results to ...
GWAS contribution to atrial fibrillation and atrial fibrillation-related stroke: pathophysiological implications [0.03%]
全基因组关联研究对房颤及房颤相关卒中的贡献：病理生理意义
Diana Cruz,Ricardo Pinto,Margarida Freitas-Silva et al.
Diana Cruz et al.
Atrial fibrillation (AF) and stroke are included in a group of complex traits that have been approached regarding of their study by susceptibility genetic determinants. Since 2007, several genome-wide association studies (GWAS) aiming to id...
Development of a rapid and reliable single-tube multiplex real-time PCR method for HLA-A*24:02 genotyping [0.03%]
一种HLA-A*24:02基因型鉴定的快速可靠的单管多重实时PCR方法的研究与发展
Yanxia Wang,Tingting Zhang,Lirong Zhang et al.
Yanxia Wang et al.
Aim:HLA-A*24:02 is significantly associated with cutaneous adverse drug reactions caused by aromatic antiepileptic drugs. Here, we aimed to establish a fast and reliable detection method for HLA-A*24:02 genotyping. Methods: A single-tube mu...
Larisa H Cavallari,Julie A Johnson
Larisa H Cavallari
Resequencing CYP2D6 gene in Indian population: CYP2D6*41 identified as the major reduced function allele [0.03%]
印度人群CYP2D6基因重测序：%CYP2D6*41%被确定为功能降低型等位基因
Aarthi Manoharan,Deepak Gopal Shewade,Pradeep Anand Ravindranath et al.
Aarthi Manoharan et al.
Aim: The CYP2D6 gene is highly polymorphic and harbors population specific alleles that define its predominant metabolizer phenotype. This study aimed to identify polymorphisms in Indian population owing to scarcity of CYP2D6 data in this p...
Colorectal cancer: pharmacogenetics support for the correct drug prescription [0.03%]
结直肠癌：药物基因组学支持正确用药处方
Gladys Olivera,Luis Sendra,María José Herrero et al.
Gladys Olivera et al.
Pharmacogenetics (PGx) in clinical practice is a tool that the clinician can use to guide, in a personalized way, the most suitable treatment that will be administered to the patient. The objective of this review is to summarize in a practi...
Theodora Katsila,Angeliki Balasopoulou,Ioanna Tsagaraki et al.
Theodora Katsila et al.
Aim: Microbiota-host-xenobiotics interactions in humans become of prime interest when clinical pharmacogenomics is to be implemented. Despite the advent of technology, information still needs to be translated into knowledge for optimum pati...
Justyna Suwała,Marta Machowska,Anna Wiela-Hojeńska
Justyna Suwała
Antidepressant response could be from 42 to 50% genetically determined. Venlafaxine (VEN) was the sixth most-prescribed antidepressant in the USA in 2017. Therefore, we reviewed studies which focused on the pharmacogenetics of VEN and found...
Genetic variants and interactions from a pharmacist-led pharmacogenomics service for PACE [0.03%]
药学主导的PACE药物基因组学服务中的基因变异和位点效应分析
Kevin T Bain,Adriana Matos,Calvin H Knowlton et al.
Kevin T Bain et al.
Aim: Evaluate results of pharmacogenomics testing for participants enrolled in the Program of All-inclusive Care for the Elderly (PACE). Materials & methods: A convenience sample of 100 participants from the PHARM-GENOME-PACE study. Genetic...