Pharmacogenomics in chronic pain therapy: from disease to treatment and challenges for clinical practice [0.03%]
慢性疼痛治疗中的药物基因组学：从疾病到治疗及临床实践挑战
Priscila Akemi Yamamoto,Ana Carolina Conchon Costa,Gabriela Rocha Lauretti et al.
Priscila Akemi Yamamoto et al.
Pharmacogenomics (PGx) has emerged as an encouraging tool in chronic pain therapy. Genetic variations associated with drug effectiveness or adverse reactions (amitriptyline/nortriptyline/codeine/oxycodone/tramadol-CYP2D6, amitriptyline-CYP2...
Natasha Petry,Jordan Baye,Aissa Aifaoui et al.
Natasha Petry et al.
The convergence of translational genomics and biomedical informatics has changed healthcare delivery. Institutional consortia have begun implementing lab testing and decision support for drug-gene interactions. Aggregate datasets are now re...
Low-frequency variants at the CYP2C9 locus among Puerto Rican patients on warfarin: in silico predictions of functionality and conservation [0.03%]
波多黎各接受华法林治疗患者中CYP2C9基因座的低频变异：功能和保守性预测
Karla Claudio-Campos,Mariangeli Moneró-Paredes,Eliud Hernández et al.
Karla Claudio-Campos et al.
Aim: Perform in silico predictions of functional consequences of CYP2C9 variants identified by next-generation sequencing in Puerto Ricans. Methods: Identified low-frequency CYP2C9 variants (minor allele frequencies
Clinical Trial
Pharmacogenomics. 2019 Aug;20(12):891-902. DOI:10.2217/pgs-2019-0051 2019
Implementation of pharmacogenetics in a clozapine treatment resistant patient: a case report [0.03%]
氯氮平治疗抵抗患者的药物基因组学实施案例报告
Estela Sangüesa,Christine Cirujeda,Julia Concha et al.
Estela Sangüesa et al.
We report the case of a young Caucasian male with disorganized chronic schizophrenia, an active smoker and nonresponder to 400 mg of clozapine/day. Therapeutic clozapine monitoring was analyzed revealing a low clozapine:norclozapine ratio. ...
Case Reports
Pharmacogenomics. 2019 Aug;20(12):871-877. DOI:10.2217/pgs-2019-0074 2019
Pharmacogenomics in the Nigerian population: the past, the present and the future [0.03%]
尼日利亚人群的药物基因组学：过去、现在和未来
Oluseye O Bolaji,Ayorinde Adehin,Babatunde A Adeagbo
Oluseye O Bolaji
The Nigerian population exhibits huge ethnic and genetic diversity, typical of African populations, which can be harnessed for improved drug-response and disease management. Existing data on genes relevant to drug response, so far generated...
DEPTOR polymorphisms influence late complications in Type 2 diabetes patients [0.03%]
DEPTOR多态性影响2型糖尿病患者的远期并发症
Jasna Klen,Katja Goričar,Simon Horvat et al.
Jasna Klen et al.
Aim: We investigated if DEPTOR polymorphisms influence metabolic parameters and risk for vascular complications in Type 2 diabetes (T2D) patients. Methods: T2D patients were genotyped for DEPTOR rs7840156, rs2271900 and rs4871827. We built ...
Laura B Ramsey,Jeffrey R Bishop,Jeffrey R Strawn
Laura B Ramsey
Pharmacogenomic considerations for medications in the perioperative setting [0.03%]
围手术期药物的药理基因组学考虑因素
Ellie H Jhun,Jeffrey L Apfelbaum,David M Dickerson et al.
Ellie H Jhun et al.
Several high-profile examples of adverse outcomes from medications used in the perioperative setting are well known (e.g., malignant hyperthermia, prolonged apnea, respiratory depression, inadequate analgesia), leading to an increased under...
Genomic variants in members of the Krüppel-like factor gene family are associated with disease severity and hydroxyurea treatment efficacy in β-hemoglobinopathies patients [0.03%]
Krüppel样因子基因家族成员的基因组变异与β型血红蛋白病患者的疾病严重程度和羟基脲治疗效果相关性研究
Apostolos Stratopoulos,Alexandra Kolliopoulou,Kariofyllis Karamperis et al.
Apostolos Stratopoulos et al.
Aim: β-Type hemoglobinopathies are characterized by vast phenotypic diversity as far as disease severity is concerned, while differences have also been observed in hydroxyurea (HU) treatment efficacy. These differences are partly attribute...
Genomic variants in members of the Krüppel-like factor gene family are associated with disease severity and hydroxyurea treatment efficacy in β-hemoglobinopathies patients [0.03%]
Krüppel样因子基因家族成员的基因组变异与β型血红蛋白病患者的疾病严重程度和羟基脲治疗效果相关性研究
Apostolos Stratopoulos,Alexandra Kolliopoulou,Kariofyllis Karamperis et al.
Apostolos Stratopoulos et al.
Aim: β-Type hemoglobinopathies are characterized by vast phenotypic diversity as far as disease severity is concerned, while differences have also been observed in hydroxyurea (HU) treatment efficacy. These differences are partly attribute...