Marina Borro,Martina Guglielmetti,Maurizio Simmaco et al.
Marina Borro et al.
Migraine is considered one of the most disabling neurological disorder with a high socioeconomic burden. Pharmacological management includes many classes of drugs which in the most cases, are administrated in polytherapy. The therapeutic sc...
Sony Tuteja
Sony Tuteja
Niacin (nicotinic acid) is a potent lipid-lowering agent that has been used for prevention of coronary heart disease. Niacin activates the HCAR2 receptor found on adipocytes, macrophages and various immune cells throughout the body. Activat...
Use of circulating tumoral DNA to guide treatment for metastatic melanoma [0.03%]
循环肿瘤DNA指导转移性黑色素瘤治疗的作用
Guillaume Herbreteau,Sandrine Charpentier,Audrey Vallée et al.
Guillaume Herbreteau et al.
The management of metastatic cutaneous melanoma is conditioned by the identification of BRAF-activating mutations in tumor DNA. Tumor genotyping is usually performed on DNA extracted from tissue samples. However, these invasive samples are ...
Impact of CYP3A4/5 and ABCB1 polymorphisms on tacrolimus exposure and response in pediatric primary nephrotic syndrome [0.03%]
儿童原发性肾病综合征患者他克莫司血药浓度影响因素及药物暴露效应关系研究——多中心回顾性队列遗传学分析
Lingfei Huang,Junyan Wang,Jufei Yang et al.
Lingfei Huang et al.
Aim: To evaluate the impact of CYP3A4*1G, CYP3A5*3 and ABCB1-C3435T polymorphisms on tacrolimus concentrations, efficacy and tolerance in pediatric primary nephrotic syndrome. Methods: Dose-adjusted concentrations (C0/D), daily dose, freque...
CYP3A5 is unlikely to mediate anticancer drug resistance in hepatocellular carcinoma [0.03%]
CYP3A5很可能不会介导肝细胞癌的抗癌药耐药性
Volker M Lauschke,Åsa Nordling,Yitian Zhou et al.
Volker M Lauschke et al.
Recently, it was published that CYP3A5 contributes to chemotherapeutic drug resistance in a wide range of solid tumors, including hepatocellular carcinoma. However, CYP3A5 is highly polymorphic and 90% of Caucasians are homozygous for the l...
A stepwise approach to implementing pharmacogenetic testing in the primary care setting [0.03%]
初级保健机构实施药物基因分型检测的逐步方法
Kristin Wiisanen Weitzel,Benjamin Q Duong,Meghan J Arwood et al.
Kristin Wiisanen Weitzel et al.
Pharmacogenetic testing can help identify primary care patients at increased risk for medication toxicity, poor response or treatment failure and inform drug therapy. While testing availability is increasing, providers are unprepared to rou...
4th ESPT Conference: pharmacogenomics and personalized medicine - research progress and clinical implementation [0.03%]
第四届ESPT大会：药物基因组学与个性化医疗——研究进展和临床实施
Csilla Sipeky,Adrián Llerena,Vangelis G Manolopoulos et al.
Csilla Sipeky et al.
The Fourth European Society of Pharmacogenomics and Personalized Therapy biennial conference was organized in collaboration with the Italian Society of Personalized Medicine (SIMeP) and was held at Benedictine Monastery of San Nicolò l'Are...
Nada Božina,Ivana Šušak Sporiš,Tamara Božina et al.
Nada Božina et al.
Seizure control with antiepileptic drugs (AEDs) as well as susceptibility to adverse drug reactions varies among individuals with epilepsy. This interindividual variability is partly determined by genetic factors. However, genetic testing t...
Graeme K Suthers,Tom M Polasek
Graeme K Suthers
Letter regarding: Bousman CA, Arandjelovic K, Mancuso SG, Eyre HA, Dunlop BW. Pharmacogenetic tests and depressive symptom remission: a meta-analysis of randomized controlled trials. Pharmacogenomics 20(1), 37-47 (2019). ...
APOE polymorphism is associated with blood lipid and serum uric acid metabolism in hypertension or coronary heart disease in a Chinese population [0.03%]
载脂蛋白E基因多态性与中国人群高血压或冠心病患者血脂及血尿酸代谢的关系
Canwang Wang,Wanli Yan,Huan Wang et al.
Canwang Wang et al.
Aim: To explore the association of APOE polymorphism (rs7412:526C>T and rs429358:388T>C) with glucose, lipid and serum uric acid (UA) metabolism in patients with hypertension or coronary heart disease (CHD). Methods: A total of 544 patients...