Jia Yu,Jacqueline Zayas,Bo Qin et al.
Jia Yu et al.
Triple-negative breast cancer (TNBC) accounts for 15-20% of all invasive breast cancers and tends to have aggressive histological features and poor clinical outcomes. Unlike, estrogen receptor- or HER2-positive diseases, TNBC patients curre...
NAT2 slow acetylator is associated with anti-tuberculosis drug-induced liver injury severity in indonesian population [0.03%]
NAT2慢代谢型与印尼人群结核病抗结核药物引起的肝损伤严重程度相关性研究
Rika Yuliwulandari,Kinasih Prayuni,Retno Wilujeng Susilowati et al.
Rika Yuliwulandari et al.
Aim: We investigated the contribution of NAT2 variants and acetylator status to anti-tuberculosis drug-induced liver injury (AT-DILI) severity. Materials & methods: 100 patients with clinically severe AT-DILI and 210 non-AT-DILI controls we...
Vincent Camus,Fabrice Jardin
Vincent Camus
The technique of cell-free DNA (cfDNA) analysis, also called liquid biopsy, has been developed over the past several years to serve as a minimal residual disease tool, as has already been done with reliability and robustness in acute leukem...
Combination of germline variations associated with survival of folinic acid, fluorouracil and irinotecan-treated metastatic colorectal cancer patients [0.03%]
叶酸、氟尿嘧啶和伊立替康治疗的转移性结直肠癌患者的生存相关的基因组变异组合分析
Adrien Labriet,Éric Lévesque,Elena De Mattia et al.
Adrien Labriet et al.
Aim: Germline variants could modify survival of metastatic colorectal cancer patients (mCRC). Patients & methods: The association of 285 haplotype-tagging SNPs in 11 candidate genes and overall survival (OS) was tested in two cohorts totali...
Pavel Vodicka,Sona Vodenkova,Tomas Buchler et al.
Pavel Vodicka et al.
DNA repair, a complex biological process, ensures genomic integrity. Alterations in DNA repair, occurring in many cancers, contribute to the accumulation of mutations in the genome, resulting in genomic instability and cancer progression. D...
Marzia Del Re,Giulia Gianfilippo,Stefania Crucitta et al.
Marzia Del Re et al.
Severe and prolonged cyclophosphamide-induced hepatotoxicity in a breast cancer patient carrying a CYP2B6*7 variant [0.03%]
乳腺癌患者携带CYP2B6*7变异致严重且持续的环磷酰胺肝毒性
Zhao Ming,Zhang Yongqiang,Zhang Zijin et al.
Zhao Ming et al.
As a widely used alkylating agent, cyclophosphamide often leads to various toxicities. Severe hepatotoxicity has been rarely reported in breast cancer patients receiving chemotherapy containing cyclophosphamide. Differences in cyclophospham...
Putative role of pharmacogenetics to elucidate the mechanism of tardive dyskinesia in schizophrenia [0.03%]
药物基因组学在阐明精神分裂症迟发性运动障碍机制中的潜在作用
Anton Jm Loonen,Bob Wilffert,Svetlana A Ivanova
Anton Jm Loonen
Identifying biomarkers which can be used as a diagnostic tool is a major objective of pharmacogenetic studies. Most mental and many neurological disorders have a compiled multifaceted nature, which may be the reason why this endeavor has hi...
Genes identified through genome-wide association studies of osteonecrosis in childhood acute lymphoblastic leukemia patients [0.03%]
儿童急性淋巴细胞白血病患者骨坏死的全基因组关联研究中鉴定出的基因
Vincent Gagné,Anne Aubry-Morin,Maria Plesa et al.
Vincent Gagné et al.
Aim: To evaluate top-ranking genes identified through genome-wide association studies for an association with corticosteroid-related osteonecrosis in children with acute lymphoblastic leukemia (ALL) who received Dana-Farber Cancer Institute...
Methotrexate pharmacogenetics in the treatment of rheumatoid arthritis [0.03%]
治疗类风湿性关节炎的甲氨蝶呤药物基因组学研究进展
Biljana Jekic,Nela Maksimovic,Tatjana Damnjanovic
Biljana Jekic
For many decades, methotrexate (MXT) has remained the drug of choice in the treatment of rheumatoid arthritis (RA). Unfortunately, a considerable number of patients do not achieve an appropriate therapeutic response. Pharmacogenetics studie...