How to implement pre-emptive pharmacogenetic testing in the acute hospital setting [0.03%]
急性护理环境中如何实施主动性的药物基因检测
John Henry McDermott,Ali Shoaib,Jessica Keen et al.
John Henry McDermott et al.
Your hospital has decided to introduce a pharmacogenomics program. What do you need to do to realize this ambition? In this paper, we set out the elements that should be considered, including the team and resources required to establish a s...
Assessing patient understanding of pharmacogenomic test results: a qualitative study [0.03%]
评估患者对药物基因组检测结果的理解：一项定性研究
Tom A Doyle,Samantha L Vershaw,Karen K Schmidt et al.
Tom A Doyle et al.
Aim: To examine whether patients with depression or chronic/acute pain understand the results of pharmacogenomic testing they had done as part of clinical research. ...
Exploring precision medicine by utilizing individual genetic information for the management of Alzheimer's disease [0.03%]
利用个体遗传信息指导精准医疗以管理阿尔茨海默病
Anmol Kanda,Anjna Rani,Avijit Mazumder
Anmol Kanda
Alzheimer's Disease (AD) represents a formidable challenge in neurology, characterized by progressive neurodegeneration and cognitive decline. Traditional therapeutic approaches have failed to deliver significant outcomes, underscoring the ...
Joe Chalhoub,Mélissa El Hajj,Tia Kreidy et al.
Joe Chalhoub et al.
Breast cancer is the most common malignancy in women worldwide. While personalized treatment options are obstructed by the limitations of conventional biopsy follow-up, the liquid biopsy could detect the tumor's characteristics in order to ...
A genome-wide association study of stroke risk in Asian statin users: evidence from KoGES and UK Biobank [0.03%]
一项亚洲他汀类药物使用者的卒中风险全基因组关联研究：来自韩国基因与环境协会和英国生物样本库的证据
Da Hoon Lee,Yoon-A Park,Jung Sun Kim et al.
Da Hoon Lee et al.
Background: Despite proven efficacy of statins in stroke prevention, genetic factors may influence individual stroke risk among statin users. With increasing precision medicine approaches and growing evidence of populatio...
Pharmacogenomic variants affecting efficacy and safety of medicines acting on central nervous system among Sri Lankans [0.03%]
斯里兰卡人群中枢神经系统药物效应和安全性的药理遗传变异的影响
Priyanga Ranasinghe,Charindie Peiris,Hajanthy Jeyapragasam et al.
Priyanga Ranasinghe et al.
Background: Ensuring the efficacy and safety of medicines acting on the central nervous system (CNS) remains a challenge due to their complex pharmacokinetics and inter-individual variability in response. We describe the ...
Lakshmi Aravindan,Sanjana Velu,Inesh Sivam et al.
Lakshmi Aravindan et al.
Buprenorphine, a semi-synthetic opioid, is used to treat Opioid Use Disorder (OUD) and as an analgesic. Buprenorphine's benefits over other opioids include longer duration of action, lower abuse potential, and a ceiling effect to serious ad...
The pharmacogenetics of rosuvastatin and implications for treatment: a systematic review [0.03%]
罗苏伐他汀的药物基因组学及其对治疗的意义：系统性综述
Eva González-Iglesias,Jesús Novalbos,Francisco Abad-Santos
Eva González-Iglesias
Introduction: Rosuvastatin has become a good choice in the statin group because it has shown greater efficacy in reducing lipid levels than other statins, allowing patients to reach their therapeutic goal more quickly. To...
Genetic polymorphism associated with non-response to therapy in inflammatory bowel disease patients: a review [0.03%]
炎症性肠病患者治疗无反应相关的遗传多态性：综述
Thinagary Jegathesan,Syaratul Dalina Yusoff,Nor Asyikin Mohd Tahir
Thinagary Jegathesan
Inflammatory bowel disease (IBD) poses a major therapeutic challenge due to its chronic course and variable treatment responses. Genetic polymorphisms significantly influence drug efficacy, prompting this review to analyze their role in tre...
Opportunistic analysis of clinically actionable DPYD gene variants in a germline testing cohort in India [0.03%]
在印度遗传学检测队列中针对临床操作性DPYD基因变异体的机会主义分析
Rajdeep Raha,Rahul C Bhoyar,Ranendra Pratap Biswal et al.
Rajdeep Raha et al.
Aims: Dihydropyrimidine dehydrogenase (DPYD) plays a critical role in the metabolism of fluoropyrimidine-based chemotherapies such as 5-fluorouracil (5-FU), capecitabine, and tegafur. Genetic variants in DPYD can lead to ...