The impact of GST genetic polymorphisms on the response to oxaliplatin-based chemotherapy and survival prognosis in gastric cancer patients [0.03%]
GST基因多态性对胃癌患者奥沙利铂为基础的化疗反应及预后影响研究
Jiaodi Zhang,Qi Jin,Tao Chen et al.
Jiaodi Zhang et al.
Aim: This study aimed to assess the impact of GSTP1, GSTM1, and GSTT1 polymorphisms on the response to oxaliplatin-based chemotherapy and survival outcomes in gastric cancer patients from Northwest China. ...
J F Vieira,I H Tassoni,M L Chaves et al.
J F Vieira et al.
The CYP2C19 gene encodes one of the main enzymes responsible for clopidogrel bioactivation, a widely prescribed antiplatelet prodrug. Due to its high polymorphism, clopidogrel response varies considerably, especially in carriers of nonfunct...
Sara Labay-Tejado,Mercè Brunet,Elena Milla
Sara Labay-Tejado
Glaucoma is a chronic, degenerative eye disease for which personalized diagnostic and therapeutic biomarkers are still lacking. Precision medicine offers a promising strategy to improve glaucoma management, and pharmacogenomics may play a k...
Characterizing models for delivery of pharmacogenomic testing: a scoping review [0.03%]
药学基因分型检测递送模型的特征：综述性研究
Zeina Waheed,Mary Bunka,Louisa Edwards et al.
Zeina Waheed et al.
Pharmacogenomic (PGx) testing can help guide medication prescribing for a wide range of health indications. The objective of this scoping review was to understand how PGx testing has been clinically implemented and learn from these experien...
ADIPOQ genotypes and haplotypes, circulating adiponectin levels and responsiveness to antihypertensive therapy in preeclampsia [0.03%]
ADIPOQ基因型和单倍体型、循环脂联素水平及重度子痫前期患者对降压治疗的反应性
Daniela A Pereira,Ricardo N F de Castro,Ana C Palei et al.
Daniela A Pereira et al.
Aims: We compared plasma adiponectin levels between patients with preeclampsia (PE) classified as responsive and nonresponsive to antihypertensive therapy; Moreover, we examined whether ADIPOQ SNPs rs17300539, rs266729,rs...
Laurence Tessier,Sophie St-Amour,Dorianne Simard et al.
Laurence Tessier et al.
Diabetes is a chronic disease that affects approximately 589 million people worldwide. Type 2 diabetes is one of its main forms (~90%) and manifests as hyperglycemia due to the resistance of myocytes and adipocytes to insulin. These are una...
Molecular markers of treatment irregularity of statins: influence of polymorphisms in SLCO1B1 and SLCO1B3 [0.03%]
他汀类药物治疗不规律的分子标志物：SLCO1B1和SLCO1B3多态性的影响
Jéssica Louise Benelli,Lisiane Smiderle,Silvana de Almeida et al.
Jéssica Louise Benelli et al.
Background and aims: The SLCO gene family encodes OATP-like transporters that interact with statins and may influence their efficacy. Consequently, these genes are key targets in pharmacogenetic studies, and associations ...
CYP2D6 genotyping in a Korean cohort: comparative analysis with Asian, Caucasian, and African populations [0.03%]
韩国人群的细胞色素P450 2D6基因分型与亚洲、高加索和非洲后裔人群的比较分析
Tak Don Kim,Jung-Sook Kwak,Jae-Gook Shin et al.
Tak Don Kim et al.
Background: Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic enzyme responsible for metabolizing approximately 20% of commonly prescribed drugs. Its genetic variability contributes to interindividual and interethnic d...
Joel E Pacyna,Suzette J Bielinski,Janet E Olson et al.
Joel E Pacyna et al.
Background: Preemptive pharmacogenomic (PGx) testing is a candidate for broad implementation because of its potential to improve medication safety and outcomes. However, little is known about how patients may process pree...
Scoping review of associations between cytochrome P450 3A4/5 single nucleotide polymorphisms and risk factors for fentanyl overdose [0.03%]
关于细胞色素P450 3A4/5单核苷酸多态性与芬太尼过量风险因素之间关联的综述研究
Dan Petrovitch,Katie P Himes,Jason J Bischof et al.
Dan Petrovitch et al.
Introduction: Fentanyl overdose is a public health crisis in the United States, as fentanyl was implicated in nearly 70% of drug overdose deaths in 2023. To provide insight into genetic factors that may influence risk of ...