Association of DNA methylation, polymorphism and mRNA level of ALAS1 with antituberculosis drug-induced liver injury [0.03%]
血红素合成途径关键基因ALAS1甲基化、多态性和mRNA水平与抗结核药物性肝损伤的关系研究
Zhuolu Hao,Bing Han,Xinyue Zhou et al.
Zhuolu Hao et al.
Aim: To investigate the association of DNA methylation, genetic polymorphisms and mRNA level of aminolevulinate synthase 1 (ALAS1) with antituberculosis drug-induced liver injury (AT-DILI) risk.Methods: Based on a 1:1 matched case-control s...
Evaluation of pharmacogenetic automated clinical decision support for clopidogrel [0.03%]
氯吡格雷用药的药理遗传学自动化临床决策支持的评估研究
Amanda Massmann,Joel Van Heukelom,Max Weaver et al.
Amanda Massmann et al.
Aim: Clopidogrel requires CYP2C19 activation to have antiplatelet effects. Pharmacogenetic testing to identify patients with impaired CYP2C19 function can be coupled with clinical decision support (CDS) alerts to guide antiplatelet prescrib...
It is time for educators to act: pharmacogenomics education and its implementation into clinical practice [0.03%]
是时候让教育工作者采取行动了：药物基因组学教育及其在临床实践中的实施
Snezana Kusljic,Jasmine A Luzum
Snezana Kusljic
Accuracy and technical characteristics of CYP2C19 point of care tests: a systematic review [0.03%]
关于CYP2C19快速检测的准确性及技术特征的系统性回顾
Eve Tomlinson,Chris Cooper,Hayley E Jones et al.
Eve Tomlinson et al.
Aim: To assess the accuracy and technical characteristics of CYP2C19 point of care tests (POCTs).Patients & methods: Systematic review of primary studies, in any population or setting, that evaluated POCTs for detecting CYP2C19 loss of func...
Meta-analysis revisiting the influence of UGT1A1*28 and UGT1A1*6 on irinotecan safety in colorectal cancer patients [0.03%]
UGT1A1*28和UGT1A1*6对结直肠癌患者伊立替康安全性影响的meta分析
Cuc Thi Thu Nguyen,Thi Minh Thuy Nguyen,Thanh Huong Phung
Cuc Thi Thu Nguyen
Aim: To evaluate the association between irinotecan safety and the UGT1A1 gene polymorphism in colorectal cancer (CRC) patients.Materials & methods: The studies were systematically searched and identified from three databases (PubMed, Embas...
Meta-Analysis
Pharmacogenomics. 2024;25(10-11):469-477. DOI:10.1080/14622416.2024.2385289 2024
Update on the PriME-PGx initiative: evolution of pharmacogenetics in daily clinical practice [0.03%]
PriME-PGx计划更新：日常临床实践中药物基因组学的发展变迁
Eva González-Iglesias,Francisco Abad-Santos
Eva González-Iglesias
In 2021, the Clinical Pharmacology Department of Hospital Universitario de La Princesa launched the PriME-PGx initiative (Multidisciplinary Initiative of the Hospital Universitario de La Princesa for the Implementation of Pharmacogenetics) ...
Implementing pharmacogenomic testing in Australian general practice: an exploratory qualitative study [0.03%]
澳大利亚全科医学实践实施药物基因组检测的探索性研究
Emma Ewasiuk,Jon Emery,Gabrielle Reid et al.
Emma Ewasiuk et al.
Aim: To explore general practitioners' (GPs) views on implementing pharmacogenomic testing in Australian general practice.Methods: Semi-structured interviews were conducted with nine GPs in Australia, recruited from primary care networks. I...
Pharmacogenetics of Calcineurin inhibitors in kidney transplant recipients: the African gap. A narrative review [0.03%]
钙调神经磷酸酶抑制剂在肾移植受者中的药物基因组学：非洲地区的差距。叙事性综述
Sadiq Aliyu Hussaini,Bala Waziri,Caroline Dickens et al.
Sadiq Aliyu Hussaini et al.
Calcineurin inhibitors (CNIs) are the mainstay of immunosuppression in kidney transplantation. Interpatient variability in the disposition of calcineurin inhibitors is a well-researched phenomenon and has a well-established genetic contribu...
Potential association of SULT2A1 and ABCG2 variant alleles with increased risk for palbociclib toxicity [0.03%]
SULT2A1和ABCG2变异等位基因与palbociclib毒性的风险增加有关的可能性
Chong Wang,Mary Hwang,Brandon Paulson et al.
Chong Wang et al.
Aim: This study evaluated associations between CYP3A4*22 and variants in other pharmacogenes (CYP3A5, SULT2A1, ABCB1, ABCG2, ERCC1) and the risk for palbociclib-associated toxicities.Materials & methods: Two hundred cancer patients who rece...
Impact of IL-6 and IL-10 genotypes on tacrolimus dose requirements in kidney transplant recipients: Monte Carlo analysis [0.03%]
白细胞介素6和白细胞介素10基因多态性对肾移植受者的他克莫司剂量需求影响的蒙特卡罗模拟分析
Nikola Stefanović,Katarina Danković,Tatjana Cvetković et al.
Nikola Stefanović et al.
Introduction: IL-6 and IL-10 may affect the activity of cytochrome P450 (CYP) 3A enzymes involved in tacrolimus (Tac) metabolism. Moreover, the effect of IL-6 and IL-10 on Tac pharmacokinetics may differ with respect to the genetic variatio...