Susanne B Haga
Susanne B Haga
Artificial Intelligence (AI) and Machine Learning (ML) are revolutionizing various scientific and clinical disciplines including pharmacogenomics (PGx) by enabling the analysis of complex datasets and the development of predictive models. T...
Pharmacogenomics in Sri Lanka: a comprehensive systematic review of the research landscape and clinical implications [0.03%]
斯里兰卡的药物基因组学：全面系统回顾研究现状和临床意义
Priyanga Ranasinghe,Hajanthy Jeyapragasam,Sandamini Liyanage et al.
Priyanga Ranasinghe et al.
Aim: Pharmacogenomics is emerging in South Asia, including Sri Lanka, with potential to optimize drug therapy and reduce adverse effects. This review evaluates the state of pharmacogenomics research in Sri Lanka, emphasizing population-spec...
Alenka Šmid,Dunja Urbančič,Jaka Vrevc Žlajpah et al.
Alenka Šmid et al.
Determining variant TPMT alleles to predict patient response to thiopurine therapy represents one of the first successful implementations of pharmacogenomics in clinical practice. However, despite the TPMT-adjusted thiopurine dosing, some T...
Predicting laboratory aspirin resistance in Chinese stroke patients using machine learning models by GP1BA polymorphism [0.03%]
基于GP1BA多态性在中国卒中患者中使用机器学习模型预测实验室阿司匹林抵抗性
Jun Liu,Linkun Pan,Sheng Wang et al.
Jun Liu et al.
This study aims to use machine learning model to predict laboratory aspirin resistance (AR) in Chinese stroke patients by incorporating patient characteristics and single nucleotide polymorphisms of GP1BA and LTC4S. 2405 patients were analy...
Effects of immunorelated gene polymorphisms on trastuzumab targeting breast cancer cell in vitro [0.03%]
免疫相关基因多态性对曲妥珠单抗靶向乳腺癌细胞的体外影响研究
Linyu Yu,Congmin Zhang,Liangyu Liu et al.
Linyu Yu et al.
Aim: To investigate the associations between genetic polymorphisms in immunorelated genes and PBMC-induced cytotoxicity to breast cancer cell with the treatment of trastuzumab in vitro.Methods: Trastuzumab-mediated cytotoxicity of periphera...
Analysis of the current situation of pharmacogenomics in terms of educational and healthcare needs in Egypt and Lebanon [0.03%]
埃及和黎巴嫩在教育和医疗需求方面的药物基因组学现状分析
Sahar M El-Gowilly,Heba A Metwaly,Dalia Makhlouf et al.
Sahar M El-Gowilly et al.
Pharmacogenomics (PGx) is a practice that investigates the link between genetic differences and drug response in patients. This can improve treatment effectiveness and reduce harmful side effects. However, has yet to be adequately realized ...
Providers' use of pharmacogenetic testing to inform opioid prescribing among veterans [0.03%]
退伍军人用药基因组检测的提供者使用情况及对开具阿片类药物处方的影响
Rachele K Lipsky,Catherine Chanfreau-Coffinier,Deepak Voora et al.
Rachele K Lipsky et al.
Aim: To survey Veterans Health Administration providers who prescribed tramadol or codeine to patients with known genotyping for cytochrome 2D6 (CYP2D6) to ascertain awareness of their patient's pharmacogenetic (PGx) test status, whether th...
Effects of genetic and clinical factors on thiopurine drugs pharmacokinetics in Tunisian patients [0.03%]
基因和临床因素对突尼斯患者硫嘌呤类药物药代动力学的影响
Zohra Chadli,Ibtissem Hannachi,Manel Ben Belgacem et al.
Zohra Chadli et al.
Aim: Thiopurine drugs are used in the treatment of various diseases including inflammatory bowel disease. Thiopurine-S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) are the crucial enzymes involved in thiopurines ...
Real-world evaluation of CYP2C19 guided antiplatelet therapy in patients undergoing intracranial aneurysm repair [0.03%]
颅内动脉瘤修复患者的临床药理学2C19指导的抗血小板治疗的真实世界评估
Layna P Fox,Kayla R Tunehag,Anh Nguyen et al.
Layna P Fox et al.
Aim: To evaluate the feasibility and impact of using CYP2C19 genotype to guide selection of antiplatelet therapy in patients undergoing intracranial aneurysm treatment with a flow diversion stent in a real-world clinical setting.Patients & ...
Observational Study
Pharmacogenomics. 2024;25(12-13):503-513. DOI:10.1080/14622416.2024.2406213 2024
A systematic review of single nucleotide polymorphisms affecting allopurinol pharmacokinetics and serum uric acid level [0.03%]
异体嘌呤药代动力学和血尿酸水平影响的单核苷多态性系统评价研究
Farah Aida A Zairol Azwan,Yi Ying Teo,Nor Asyikin Mohd Tahir et al.
Farah Aida A Zairol Azwan et al.
Aim: To summarize the effects of single nucleotide polymorphisms (SNPs) on the pharmacokinetics of allopurinol to control uric acid levels.Methods: A comprehensive search was conducted in PubMed, Web of Science and Scopus databases from inc...