Genetic variation in the glucocorticoid pathway involved in interindividual differences in the glucocorticoid treatment [0.03%]
糖皮质激素治疗的个体化差异相关的糖皮质激素通路遗传变异研究
Qian-Qian Song,Wan-Ying Xie,Yong-Jun Tang et al.
Qian-Qian Song et al.
Glucocorticoids (GCs) are widely used for treating asthma, rheumatoid arthritis, nephrotic syndrome, acute lymphoblastic leukemia and other autoimmune diseases. However, in a subgroup of patients, failure to respond to GCs is known as GC re...
Pharmacogenomics testing in a community pharmacy: patient perceptions and willingness-to-pay [0.03%]
社区药房的药物基因组学检测：患者的认知和支付意愿
Mara L Gibson,Kenneth C Hohmeier,Cindy T Smith
Mara L Gibson
Aim: To determine patient knowledge, interest and willingness-to-pay for pharmacogenomics testing in a community pharmacy. Patients & methods: ...
Association of Fcgamma receptor type 2A and 3A genotypes with rheumatoid arthritis in Chinese population [0.03%]
中国人群FcyR基因多态性与类风湿关节炎的关联研究
Yining Sun,Lingfei Mo,Xiuyuan Feng et al.
Yining Sun et al.
Aim: SNPs of FcγRs were implicated in pathogenesis of rheumatoid arthritis (RA) and treatment efficacy of TNF inhibitors (TNFi). This study aims to investigate the associations of FcγRIIa and FcγRIIIa genotypes with au...
ATP-binding casette transporter expression in acute myeloid leukemia: association with in vitro cytotoxicity and prognostic markers [0.03%]
急性髓系白血病中ATP结合盒转运蛋白的表达及其与体外细胞毒性和预后标记的关系研究
Savitha Varatharajan,Ajay Abraham,Sreeja Karathedath et al.
Savitha Varatharajan et al.
Introduction: Drug resistance and relapse are considered to be the major reasons for treatment failure in acute myeloid leukemia (AML). There is limited data on the role of ABC transporter expression on in vitro sensitivi...
Pharmacogenetic dosing of warfarin in the Han-Chinese population: a randomized trial [0.03%]
华人群体中基于药物基因组的华法林给药剂量研究——随机对照试验
Ming-Shien Wen,Kuan-Cheng Chang,Tsong-Hai Lee et al.
Ming-Shien Wen et al.
Aim: This study aimed to determine clinical utility of genotype-guided dosing for warfarin in Han-Chinese. Methods: A total of 320 pati...
Randomized Controlled Trial
Pharmacogenomics. 2017 Feb;18(3):245-253. DOI:10.2217/pgs-2016-0154 2017
Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population [0.03%]
血管紧张素转换酶抑制剂引起咳嗽的遗传变异：瑞典人群的全基因组关联研究
Pär Hallberg,Matilda Persson,Tomas Axelsson et al.
Pär Hallberg et al.
Aim: We conducted a genome-wide association study on angiotensin-converting enzyme inhibitor-induced cough and used our dataset to replicate candidate genes identified in previous studies. ...
Donors FMO3 polymorphisms affect tacrolimus elimination in Chinese liver transplant patients [0.03%]
FMO3基因多态性影响中国肝移植患者的他克莫司消除率
Lei Ren,Mujian Teng,Tao Zhang et al.
Lei Ren et al.
Aim: Flavin-containing monooxygenase (FMO) variants were potentially involved in tacrolimus metabolism in kidney transplantion. The influences of FMO3 genotypes on tacrolimus elimination in Chinese liver transplant patien...
Correlations between the enantio- and regio-selective metabolisms of warfarin [0.03%]
华法林立体选择性和区域选择性代谢的相关性研究
Harumi Takahashi,Minami Ohara,Soichi Shibata et al.
Harumi Takahashi et al.
Aim: To clarify whether the activities of multiple CYPs associated with warfarin metabolism would be correlated with each other. Methods: ...
Fine-mapping of antipsychotic response genome-wide association studies reveals novel regulatory mechanisms [0.03%]
精神药物反应的全基因组关联研究精细定位揭示了新的调控机制
Ellen S Ovenden,Britt I Drögemöller,Lize van der Merwe et al.
Ellen S Ovenden et al.
Aim: Noncoding variation has demonstrated regulatory effects on disease treatment outcomes. This study investigated the potential functionality of previously implicated noncoding variants on schizophrenia treatment respon...
Ana M Peiró,César Margarit,Adrián LLerena
Ana M Peiró