Suppression of miR-628-3p and miR-641 is involved in rifampin-mediated CYP3A4 induction in HepaRG cells [0.03%]
来氟米特通过抑制miR-628-3p和miR-641诱导CYP3A4在HepaRG细胞中的表达
Liang Yan,Jingyang Liu,Yunlong Zhao et al.
Liang Yan et al.
Aim: This study aimed to explore the role of miRNAs in rifampin-mediated induction of CYP3A4 in HepaRG cells. Materials & methods: Micr...
Association of polymorphisms in GAD1 and GAD2 genes with methamphetamine dependence [0.03%]
GAD1和GAD2基因多态性与冰毒依赖的相关性研究
Siriluk Veerasakul,Paritat Watiktinkorn,Samur Thanoi et al.
Siriluk Veerasakul et al.
Aim: Association between polymorphisms in GAD genes and methamphetamine (METH) dependence was investigated in the Thai population. Materials & methods: ...
A novel acenocoumarol pharmacogenomic dosing algorithm for the Greek population of EU-PACT trial [0.03%]
EU-PACT试验希腊人群中新型乙酰螺内酯药物基因组剂量算法的研究
Georgia Ragia,Vana Kolovou,Genovefa Kolovou et al.
Georgia Ragia et al.
Aim: To generate and validate a pharmacogenomic-guided (PG) dosing algorithm for acenocoumarol in the Greek population. To compare its performance with other PG algorithms developed for the Greek population. ...
Randomized Controlled Trial
Pharmacogenomics. 2017 Jan;18(1):23-34. DOI:10.2217/pgs-2016-0126 2017
The impact of the UGT1A1*60 allele on bilirubin serum concentrations [0.03%]
UGT1A1*60等位基因对血清胆红素水平的影响
Amy L Pasternak,Kristine R Crews,Kelly E Caudle et al.
Amy L Pasternak et al.
Aim: Identify the functional status of the uridine-diphosphate glucuronyl transferase 1A1 (UGT1A1) -3279T>G (*60) variant. Materials & methods: ...
Allogeneic hematopoietic stem cell transplantation improves the prognosis of p16-deleted adult patients with acute lymphoblastic leukemia [0.03%]
同种异体造血干细胞移植改善成人急性淋巴细胞白血病p16缺失患者的预后
Yan Wang,Guoshu Chen,Rui Cao et al.
Yan Wang et al.
Aim: The prognostic value of CDKN2A inactivation in adult patients with acute lymphoblastic leukemia (ALL) is still under debate, and the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for adult AL...
Effect of polymorphisms in CYP3A4, PPARA, NR1I2, NFKB1, ABCG2 and SLCO1B1 on the pharmacokinetics of lovastatin in healthy Chinese volunteers [0.03%]
CYP3A4、PPARA、NR1I2、NFKB1、ABCG2和SLCO1B1多态性对中国健康受试者洛伐他汀药动学的影响
Guilian Zhao,Mei Liu,Xiujun Wu et al.
Guilian Zhao et al.
Aim: This study examined whether gene polymorphisms (CYP3A4, ABCG2, SLCO1B1, NR1I2, PPARA and NFKB1) influenced the pharmacokinetics of lovastatin in Chinese healthy subjects. ...
Pathophysiology of aortic aneurysm: insights from human genetics and mouse models [0.03%]
主动脉瘤的病理生理学：来自人类基因组和小鼠模型的启示
Nicole K Wilson,Russell A Gould,Elena Gallo MacFarlane et al.
Nicole K Wilson et al.
Aneurysms are local dilations of an artery that predispose the vessel to sudden rupture. They are often asymptomatic and undiagnosed, resulting in a high mortality rate. The predisposition to develop thoracic aortic aneurysms is often genet...
Tanja Maria Brückl,Manfred Uhr
Tanja Maria Brückl
P-glycoprotein (P-gp), the gene product of ABCB1, is a drug transporter at the blood-brain barrier and could be a limiting factor for entrance of antidepressants into the brain, the target site of antidepressant action. Animal studies showe...
Polymorphisms of ABAT, SCN2A and ALDH5A1 may affect valproic acid responses in the treatment of epilepsy in Chinese [0.03%]
ABAT、SCN2A和ALDH5A1多态性可能影响中国人群癫痫治疗中丙戊酸的反应性
Xi Li,Jun Zhang,Xi Wu et al.
Xi Li et al.
Aim: The clinical efficacy of valproic acid (VPA) varies greatly among epileptic patients. To find the potential genetic factors related to VPA responses, the pharmacogenetics study was conducted. ...
The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies [0.03%]
酒精依赖中的神经免疫转录体和潜在的靶向疗法研究
Anna Warden,Emma Erickson,Gizelle Robinson et al.
Anna Warden et al.
Transcriptome profiling enables discovery of gene networks that are altered in alcoholic brains. This technique has revealed involvement of the brain's neuroimmune system in regulating alcohol abuse and dependence, and has provided potentia...