Kinesin spindle protein inhibitors in cancer: a patent review (2008 - present) [0.03%]
癌症中的动力蛋白丝分裂蛋白抑制剂专利回顾(2008-今)
Cheng Jiang,Qidong You
Cheng Jiang
Introduction: Inhibition of kinesin spindle protein (KSP) has emerged as a novel and validated therapeutic strategy against cancers. A lot of new KSP inhibitors have been identified in recent years and some of them have e...
Clostridium difficile antibodies: a patent evaluation (WO2013028810) [0.03%]
难辨梭菌抗体的专利分析(WO2013028810)
Andrea Lo Vecchio,Bartolomeo Della Ventura,Emanuele Nicastro
Andrea Lo Vecchio
Introduction: Incidence and severity of Clostridium difficile infection (CDI) are increasing worldwide. Toxins A (TcdA) and B (TcdB) and host immune response are the major determinates of CD pathogenesis and represent a n...
Glycopeptide antibiotic analogs efficient against vancomycin-resistant bacteria: a patent evaluation (WO2013022763) [0.03%]
高效对抗万古霉素耐药菌的糖肽类抗生素类似物专利点评(WO2013022763)
Eugenia N Olsufyeva,Maria N Preobrazhenskaya
Eugenia N Olsufyeva
The patent claims the preparation of vancomycin analogs equally active against bacterial strains that are primarily sensitive or resistant to this antibiotic. The pseudopeptide core of new compounds carries the amidine group that replaces t...
Yiyong Yan,Jiaheng Tan,Tianmiao Ou et al.
Yiyong Yan et al.
Introduction: DNA G-quadruplexes are four-stranded DNA structures and are widely distributed in functional regions of the human genome, such as telomeres and gene promoter regions. G-quadruplex structures can play importa...
Evaluation of WO2013076170: the use of a dihydroorotate dehydrogenase inhibitor for the treatment of psoriasis [0.03%]
WO2013076170评估:二氢乳清酸脱氢酶抑制剂在银屑病治疗中的应用评价
Peter Norman
Peter Norman
Inhibition of dihydroorotate dehydrogenase (DHODH) modulates pyrimidine biosynthesis. Effective inhibitors are immunomodulatory drugs clinically useful in the treatment of diseases such as rheumatoid arthritis, psoriatic arthritis and multi...
William Nguyen
William Nguyen
A recent patent application from Bionomics/Merck Serono describes novel compounds as blockers of the voltage-gated Kv1.3 ion channel. The blockade of this channel shows great promise as a new therapeutic target for the treatment of autoimmu...
Thomas Mavromoustakos,George Agelis,Serdar Durdagi
Thomas Mavromoustakos
Introduction: For two decades a class of pharmaceutical molecules with proved beneficial therapeutic properties, especially in hypertension, has been introduced in the market aiming to specifically prevent the detrimental...
Inhibitors of influenza viruses replication: a patent evaluation (WO2013019828) [0.03%]
流感病毒复制抑制剂专利评估报告(WO2013019828)
Yuanchao Xie,Weiguo Song,Weidong Xiao et al.
Yuanchao Xie et al.
A series of compounds incorporating two aromatic heterocycles were prepared as inhibitors of influenza virus replication in the patent. Some of them presented potent activity against influenza virus in Madin-Darby canine kidney (MDCK) cells...
β-Lactamase inhibitors: a review of the patent literature (2010 - 2013) [0.03%]
头孢他啶/阿维巴坦耐药的克服:2010-2013年专利文献回顾
John D Buynak
John D Buynak
Introduction: New β-lactamases with ever-broadening substrate specificity are rapidly disseminating globally, thereby threatening the efficacy of our best β-lactam antibiotics. A potential solution to this problem is th...
Yi Wang,Pei Wang,Hongguang Ma et al.
Yi Wang et al.
Introduction: 2,5-Diketopiperazines (DKPs) are cyclic dipeptides from two amino acids with or without further structural modifications in DKP nucleus. These DKPs demonstrated attractive bioactive diversity and potential i...