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期刊名:Expert opinion on therapeutic patents

缩写:EXPERT OPIN THER PAT

ISSN:1354-3776

e-ISSN:1744-7674

IF/分区:4.6/Q1

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共收录本刊相关文章索引1521
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Cheng Jiang,Qidong You Cheng Jiang
Introduction: Inhibition of kinesin spindle protein (KSP) has emerged as a novel and validated therapeutic strategy against cancers. A lot of new KSP inhibitors have been identified in recent years and some of them have e...
Andrea Lo Vecchio,Bartolomeo Della Ventura,Emanuele Nicastro Andrea Lo Vecchio
Introduction: Incidence and severity of Clostridium difficile infection (CDI) are increasing worldwide. Toxins A (TcdA) and B (TcdB) and host immune response are the major determinates of CD pathogenesis and represent a n...
Eugenia N Olsufyeva,Maria N Preobrazhenskaya Eugenia N Olsufyeva
The patent claims the preparation of vancomycin analogs equally active against bacterial strains that are primarily sensitive or resistant to this antibiotic. The pseudopeptide core of new compounds carries the amidine group that replaces t...
Yiyong Yan,Jiaheng Tan,Tianmiao Ou et al. Yiyong Yan et al.
Introduction: DNA G-quadruplexes are four-stranded DNA structures and are widely distributed in functional regions of the human genome, such as telomeres and gene promoter regions. G-quadruplex structures can play importa...
Peter Norman Peter Norman
Inhibition of dihydroorotate dehydrogenase (DHODH) modulates pyrimidine biosynthesis. Effective inhibitors are immunomodulatory drugs clinically useful in the treatment of diseases such as rheumatoid arthritis, psoriatic arthritis and multi...
William Nguyen William Nguyen
A recent patent application from Bionomics/Merck Serono describes novel compounds as blockers of the voltage-gated Kv1.3 ion channel. The blockade of this channel shows great promise as a new therapeutic target for the treatment of autoimmu...
Thomas Mavromoustakos,George Agelis,Serdar Durdagi Thomas Mavromoustakos
Introduction: For two decades a class of pharmaceutical molecules with proved beneficial therapeutic properties, especially in hypertension, has been introduced in the market aiming to specifically prevent the detrimental...
Yuanchao Xie,Weiguo Song,Weidong Xiao et al. Yuanchao Xie et al.
A series of compounds incorporating two aromatic heterocycles were prepared as inhibitors of influenza virus replication in the patent. Some of them presented potent activity against influenza virus in Madin-Darby canine kidney (MDCK) cells...
John D Buynak John D Buynak
Introduction: New β-lactamases with ever-broadening substrate specificity are rapidly disseminating globally, thereby threatening the efficacy of our best β-lactam antibiotics. A potential solution to this problem is th...
Yi Wang,Pei Wang,Hongguang Ma et al. Yi Wang et al.
Introduction: 2,5-Diketopiperazines (DKPs) are cyclic dipeptides from two amino acids with or without further structural modifications in DKP nucleus. These DKPs demonstrated attractive bioactive diversity and potential i...