Recent advances in the development of P2Y14R inhibitors: a patent and literature review (2018-present) [0.03%]
近年P2Y14受体抑制剂研发进展：专利与文献评述（2018年至今）
Kai Wang,Fen Zhong,Zhou-Dong Zhang et al.
Kai Wang et al.
Introduction: The P2Y14 receptor (P2Y14R), a member of the G protein-coupled receptor family, is activated by extracellular nucleotides. Due to its involvement in inflammatory, immunological and other associated processes...
Patent review of cannabinoid receptor type 2 (CB2R) modulators (2016-present) [0.03%]
2016年至今大麻素受体2(CB2R)调节剂专利分析
Miroslav Kosar,Leonard Mach,Erick M Carreira et al.
Miroslav Kosar et al.
Introduction: Cannabinoid receptor type 2 (CB2R), predominantly expressed in immune tissues, is believed to play a crucial role within the body's protective mechanisms. Its modulation holds immense therapeutic promise for...
Yuhang Li,Le Yang,Xiaoran Li et al.
Yuhang Li et al.
Introduction: KRAS is a critical oncogenic protein intricately involved in tumor progression, and the difficulty in targeting KRAS has led it to be classified as an 'undruggable target.' Among the various KRAS mutations, ...
A patent review on hypoxia-inducible factor (HIF) modulators (2021-2023) [0.03%]
2021年至2023年低氧诱导因子(HIF)调节剂专利分析综述
Jiaming Liu,Yinli Gao,Xiaojin Zhang
Jiaming Liu
Introduction: Hypoxia-inducible factor (HIF) is a central regulatory factor in detecting and adapting to cellular oxygen stress. Dysregulation of HIF is associated with various human diseases. Seven HIF modulators, includ...
HDAC3 inhibitors: a patent review of their broad-spectrum applications as therapeutic agents [0.03%]
组蛋白去乙酰化酶3抑制剂的专利分析及其作为广谱治疗药物的潜在应用评估
Thabo Brighton Makgoba,Erika Kapp,Samuel Egieyeh et al.
Thabo Brighton Makgoba et al.
Introduction: Histone deacetylases (HDACs) are a class of zinc-dependent enzymes. They maintain acetylation homeostasis, with numerous biological functions and are associated with many diseases. HDAC3 strictly requires mu...
Claudiu T Supuran
Claudiu T Supuran
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) in cancer: a patent review [0.03%]
抗癌中的烟酰胺单核苷酸磷酸化酶抑制：专利回顾
Massimiliano Gasparrini,Simone Giovannuzzi,Alessio Nocentini et al.
Massimiliano Gasparrini et al.
Introduction: Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the biosynthesis of nicotinamide adenine dinucleotide (NAD) from nicotinamide. In addition to its role as essential redox cofacto...
Management of Neisseria gonorrhoeae infection: from drug resistance to drug repurposing [0.03%]
淋病奈瑟菌感染的防治策略：从耐药到老药新用
Luigi Pisano,Simone Giovannuzzi,Claudiu T Supuran
Luigi Pisano
Introduction: Neisseria gonorrhoeae is a common sexually transmitted disease connected with extensive drug resistance to many antibiotics. Presently, only expanded spectrum cephalosporins (ceftriaxone and cefixime) and az...
An updated patent review of stimulator of interferon genes agonists (2021 - present) [0.03%]
2021年以来STING激动剂专利现状分析
Guo-Feng Xin,Nan-Nan Chen,Lin-Lin Li et al.
Guo-Feng Xin et al.
Introduction: Stimulator of Interferon Genes (STING) is an innate immune sensor. Activation of STING triggers a downstream response that results in the expression of proinflammatory cytokines (TNF-α, IL-1β) via nuclear ...
Rosa Maria Vitale,Luciano de Petrocellis,Pietro Amodeo
Rosa Maria Vitale
Introduction: TRPA1 is a nonselective calcium channel, a member of the transient receptor potential (TRP) superfamily, also referred to as the 'irritant' receptor, being activated by pungent and noxious exogenous chemical...