Therapeutic modulators of the serotonin 5-HT4 receptor: a patent review (2014-present) [0.03%]
五羟色胺受体专利综述(2014-今)
Caroline Lanthier,Patrick Dallemagne,Cédric Lecoutey et al.
Caroline Lanthier et al.
Introduction: Numerous chemotypes have been described over time in order to generate potent and selective 5-HT4R ligands. Both agonists and antagonists have demonstrated their interest in several disease models. This culm...
Bispecific anti-PD-1/LAG-3 antibodies for treatment of advanced or metastatic solid tumors: a patent evaluation of US2018326054 [0.03%]
评估用于治疗晚期或转移性实体瘤的双特异性抗PD-1/LAG-3抗体：美国专利US2018326054号
Jorge Cebada,Amira Flores,Cindy Bandala et al.
Jorge Cebada et al.
Introduction: Due to the primary role of PD-1 and LAG-3 in regulating the immune response in tumors, there is a need to develop therapies focused on the inhibition of PD-1 and LAG-3 in order to improve the immune response...
Nakita Reddy,Mbongeni Shungube,Per I Arvidsson et al.
Nakita Reddy et al.
Introduction: Antibiotic resistance caused by beta-lactamase expressing bacteria poses a concern given its global dissemination and proliferation. The emergence of the metallo beta-lactamases is an indefinite health threa...
Mattia Mori,Clemente Capasso,Fabrizio Carta et al.
Mattia Mori et al.
Patent landscape of novel technologies for combating category-A Arenavirus infections [0.03%]
用于防治A类病毒性出血热的专利布局分析研究
Harshal Sudhakar,Jignesh Bhate,Asish Kumar Patra
Harshal Sudhakar
Introduction: Arenavirus are unique category-A pathogens that are also classified as Orphan diseases. Very few options exist currently for treating Viral Hemorrhagic Fever (VHF) caused by viruses belonging to the Arenavir...
Ritu Ghildiyal,Reema Gabrani
Ritu Ghildiyal
Introduction: Chikungunya virus (CHIKV), a reemerging human arthropod borne virus, can causes global epidemic outbreaks and has become a serious health concern due to the unavailability of any antiviral therapy/vaccine. Extensive research h...
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019 [0.03%]
端粒酶调节剂的研究进展：2015-2019年专利回顾
Nicola Mautone,Clemens Zwergel,Antonello Mai et al.
Nicola Mautone et al.
In recent years, sirtuins (SIRTs) gained an increasing consideration because of their multiple key roles in several biological settings such as the regulation of transcription, energetic metabolism, cell cycle progression, and cytodifferent...
An updated patent review of p38 MAP kinase inhibitors (2014-2019) [0.03%]
2014-2019年p38_MAPK抑制剂专利分析更新
Vanessa Haller,Philipp Nahidino,Michael Forster et al.
Vanessa Haller et al.
Introduction: During the first half of the last decade the p38 MAP kinase family was a very popular target in academic as well as industrial research programs. Many attempts to achieve marketing authorization for a p38 MAPK inhibitor for th...
GABAA receptor subtype modulators in medicinal chemistry: an updated patent review (2014-present) [0.03%]
药物化学中的GABA受体亚型调节剂（2014年至今）专利回顾
Letizia Crocetti,Gabriella Guerrini
Letizia Crocetti
Introduction: Ligands at the benzodiazepine binding site of the GABAA receptor (GABAAR) act by modulating the effect of GABA (γ-aminobutyric acid). The benzodiazepine drugs are conventionally categorized as positive allosteric modulators e...
Patented therapeutic drug delivery strategies for targeting pulmonary diseases [0.03%]
靶向肺部疾病的药物递送疗法发明专利策略分析
Ajay Kumar Thakur,Dinesh Kumar Chellappan,Kamal Dua et al.
Ajay Kumar Thakur et al.
Introduction: Pulmonary route is one of the preferred routes for the administration of therapeutically active agents for systemic as well as localized delivery. Chronic obstructive pulmonary disease (COPD), bronchial asthma, pneumonia, pulm...