GABAA receptor subtype modulators in medicinal chemistry: an updated patent review (2014-present)
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Introduction: Ligands at the benzodiazepine binding site of the GABAA receptor (GABAAR) act by modulating the effect of GABA (γ-aminobutyric acid). The benzodiazepine drugs are conventionally categorized as positive allosteric modulators enhancing the chlorid... ...