Snehal Kadam,Megha Khaitan,Paromita Banerjee et al.
Snehal Kadam et al.
Introduction: Iron is a crucial element necessary for blood formation in the body and its normal growth. However, irregular metabolism of iron due to absence of an elimination mechanism may deposit excess iron in the orga...
A patent review of adaptor associated kinase 1 (AAK1) inhibitors (2013-present) [0.03%]
2013年至今的衔接蛋白相关激酶1(AAK1)抑制剂专利回顾
Belén Martinez-Gualda,Dominique Schols,Steven De Jonghe
Belén Martinez-Gualda
Introduction: Adaptor-associated kinase 1 (AAK1) has been proposed as being a promising drug target for the treatment of a variety of neurological and psychiatric disorders, such as schizophrenia, cognitive deficits in sc...
Phosphatidylinositol 3-kinase (PI3K) inhibitors: a recent update on inhibitor design and clinical trials (2016-2020) [0.03%]
磷脂酰肌醇-3-激酶(PI3K)抑制剂：设计与临床试验的新进展（2016-2020）
Dima A Sabbah,Rima Hajjo,Sanaa K Bardaweel et al.
Dima A Sabbah et al.
Introduction: The phosphatidylinositol 3-kinase/protein kinase-B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway plays a central role in regulating cell growth and proliferation and thus has been considered as effective anti...
Inhibitors of immuno-oncology target HPK1 - a patent review (2016 to 2020) [0.03%]
免疫肿瘤药物HPK1靶点抑制剂专利综述（2016-2020）
Ian D Linney,Neelu Kaila
Ian D Linney
Introduction: Hematopoietic progenitor kinase (HPK1), a serine/threonine kinase, which is primarily expressed in hematopoietic cells is a negative regulator of T-cell receptor and B cell signaling. Studies using genetic disruption of HPK1 f...
Metal organic frameworks (MOFs) with therapeutic and biomedical applications: a patent review [0.03%]
用于治疗和生物医学的金属有机骨架(MOFs):专利回顾
José Marcos Teixeira de Alencar Filho,Pedrita Alves Sampaio,Iure Silva de Carvalho et al.
José Marcos Teixeira de Alencar Filho et al.
Introduction: Metal organic frameworks (MOFs) are a recent group of nano porous materials with exceptional physical properties, such as large surface areas, high pore volumes, low densities and well-defined pores. This type of material has ...
Small-molecule CD73 inhibitors for the immunotherapy of cancer: a patent and literature review (2017-present) [0.03%]
癌症免疫疗法的小分子CD73抑制剂专利与文献综述(2017-至今)
Alessio Nocentini,Clemente Capasso,Claudiu T Supuran
Alessio Nocentini
Introduction: Hydrolysis of AMP to adenosine and inorganic phosphate is catalyzed by 5´-ectonucleotidase, e5NT, alias CD73, a metalloenzyme incorporating two zinc ions at its active site. e5NT is involved in crucial phys...
Judite R M Coimbra,Jorge A R Salvador
Judite R M Coimbra
Introduction: Glutaminyl cyclase (QC) enzymes catalyze the post-translational processing of several substrates with N-terminal glutamine or glutamate to form pyroglutamate (pE) residue. In addition to physiological functions, emerging evide...
GPR119 agonists for the treatment of type 2 diabetes: an updated patent review (2014-present) [0.03%]
用于治疗2型糖尿病的GPR119激动剂（2014年-至今）专利回顾
Huilan Li,Yuanying Fang,Shuchun Guo et al.
Huilan Li et al.
Introduction: Type 2 diabetes is a rapid-growing complex chronic metabolic disease characterized by hyperglycemia due to lessened insulin secretion, insulin resistance and hepatic glucose overproduction. GPR119 is a class A of G protein-cou...
Yu Guo,Yizhen Jin,Bingxue Qu et al.
Yu Guo et al.
Introduction: Akt is a widely known serine threonine kinase involved in a series of critical cellular pathways like cell survival and proliferation. With the development of small-molecule Akt inhibitors, new strategies such as covalent, pep...
Synthesis and therapeutic delivery approaches for praziquantel: a patent review (2010-present) [0.03%]
吡喹酮的合成及治疗传递方法的研究进展（2010至今）——专利评审
Tayo A Adekiya,Pradeep Kumar,Pierre P D Kondiah et al.
Tayo A Adekiya et al.
Introduction: : Among all the anti-schistosomal drugs, praziquantel has been the most widely used. However, some major challenges have been faced using the drug in the treatment of schistosome infections. ...