Small-molecule CD73 inhibitors for the immunotherapy of cancer: a patent and literature review (2017-present)
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Introduction: Hydrolysis of AMP to adenosine and inorganic phosphate is catalyzed by 5´-ectonucleotidase, e5NT, alias CD73, a metalloenzyme incorporating two zinc ions at its active site. e5NT is involved in crucial physiologica... ...
