A patent review of berberine and its derivatives with various pharmacological activities (2016-2020) [0.03%]
2016—2020年小檗碱及衍生物的专利分析及多种药理活性研究
Yuan Kong,Lin Li,Lin-Guo Zhao et al.
Yuan Kong et al.
Introduction: Berberine (BBR), as one of the outstanding representatives of isoquinoline alkaloids, has been used as an antibacterial drug for a long time in China since ancient times. Currently, a large number of studies...
Why do few drug delivery systems to combat neglected tropical diseases reach the market? An analysis from the technology's stages [0.03%]
为什么很少有用于对抗被忽视的热带病的药物输送系统进入市场？一项关于技术阶段的分析
Jabson Herber Profiro de Oliveira,Igor Eduardo Silva Arruda,José Izak Ribeiro de Araújo et al.
Jabson Herber Profiro de Oliveira et al.
Introduction: Many drugs used to combat schistosomiasis, Chagas disease, and leishmaniasis (SCL) have clinical limitations such as: high toxicity to the liver, kidneys and spleen; reproductive, gastrointestinal, and heart...
Drug discovery targeting p21-activated kinase 4 (PAK4): a patent review [0.03%]
靶向p21活化激酶4（PAK4）的药物发现：专利回顾
Hanxun Wang,Peilu Song,Yinli Gao et al.
Hanxun Wang et al.
Introduction: The Ser/Thr protein kinase PAK4 is a downstream regulator of Cdc42, mediating cytoskeleton remodeling, and cell motility, and inhibiting apoptosis and transcriptional regulation. Nowadays, efforts in PAK4 inhibitor development...
N-heterocyclic carbene metal complexes as therapeutic agents: a patent review [0.03%]
N-杂环卡宾金属配合物作为药物的应用：专利综述
Kostiantyn O Marichev,Siddappa A Patil,Shivaputra A Patil et al.
Kostiantyn O Marichev et al.
Introduction: Besides the well-established catalytic, synthetic and materials related applications of N-heterocyclic carbene (NHC) metal complexes, their use as therapeutics deserves a special attention. Many literature r...
Jun Wu,Xiao Ding,Xuefei Tan
Jun Wu
Introduction: Aldosterone synthase (AS) is a key enzyme involved in the final three rate-limiting steps of the biosynthesis pathway of aldosterone, and its inhibition has been considered as an effective strategy to treat ...
Small molecule Son of Sevenless 1 (SOS1) inhibitors: a review of the patent literature [0.03%]
小分子SOS1抑制剂专利文献综述
Severin K Thompson,Andreas Buckl,Alexander G Dossetter et al.
Severin K Thompson et al.
Introduction: Up to 30% of all human cancers are driven by the overactivation of RAS signaling. Son of Sevenless 1 (SOS1) is a central node in RAS signaling pathways and modulation of SOS1-mediated RAS activation represents a unique opportu...
Hypoxia-activated prodrug derivatives of anti-cancer drugs: a patent review 2006 - 2021 [0.03%]
抗癌药物的低氧激活前药衍生物（2006-2021）专利综述
Emilie Anduran,Ludwig J Dubois,Philippe Lambin et al.
Emilie Anduran et al.
Introduction: The hypoxic tumor microenvironment represents a persistent obstacle in the treatment of most solid tumors. In the past years, significant efforts have been made to improve the efficacy of anti-cancer drugs. ...
Mechanistically acting anti-obesity compositions/formulations of natural origin: a patent review (2010-2021) [0.03%]
天然抗肥胖药物的作用机制：2010-2021年专利回顾
Pracheta Sengupta,Niyati Tiwari,Tanya Bhatt et al.
Pracheta Sengupta et al.
Introduction: Current health trends indicate that the rate of incidence of obesity has risen considerably. According to the World Health Organization (WHO) report 2017, the issue of obesity has grown to an epidemic propor...
Ashraf A Abbas,Magda H Abdellattif,Kamal M Dawood
Ashraf A Abbas
Introduction: Bipyrazole is constituted from two pyrazole units either in their fully aromatic or partially hydrogenated forms. Pyrazoles are widely available in pharmaceutical and agrochemical products. Some pyrazoles ar...
Isabel Hamp,Thomas J O&#x;Neill,Oliver Plettenburg et al.
Isabel Hamp et al.
Introduction: MALT1 is the only human paracaspase, a protease with unique cleavage activity and substrate specificity. As a key regulator of immune responses, MALT1 has attracted attention as an immune modulatory target f...