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Small molecule Son of Sevenless 1 (SOS1) inhibitors: a review of the patent literature

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Introduction: Up to 30% of all human cancers are driven by the overactivation of RAS signaling. Son of Sevenless 1 (SOS1) is a central node in RAS signaling pathways and modulation of SOS1-mediated RAS activation represents a unique opportunity for treating RA... ...