Harnessing mismatch repair deficiency for therapeutic targeting in cancers [0.03%]
利用错配修复缺陷进行肿瘤的治疗靶向
Irem Yenidogan,Uri Tabori,Anirban Das
Irem Yenidogan
Introduction: Mismatch-repair deficiency (MMRd) is a pan-cancer mechanism resulting in high tumor mutation and microsatellite burden, leading to remarkable therapeutic success using immune checkpoint inhibition (ICI). How...
Validating novel neurodegenerative targets for future dementia therapeutics [0.03%]
验证新型神经退行性疾病的治疗靶点以应对未来的痴呆症
Emma Murphy
Emma Murphy
Autophagic failure with age: influence on metabolic disorders and prospects for therapeutic targeting [0.03%]
衰老过程中自噬功能的丧失：对代谢紊乱的影响及治疗前景展望
Emma Brand,Mbalenhle Ntuli,Benjamin Loos
Emma Brand
Introduction: Autophagy, from Greek auto, meaning self and phagein to eat, is a highly conserved cellular pathway responsible for the degradation and recycling of long-lived proteins. A functional autophagy pathway, chara...
FAM171A2 in Parkinson's disease: mechanistic insights for a future therapeutic target [0.03%]
帕金森病中的FAM171A2：未来治疗靶点的作用机制启示
Kai-Min Wu,Yizongheng Zhang,Ting-Ting Wang et al.
Kai-Min Wu et al.
GADD45: a crucial component of the dna damage response and a potential cancer therapeutic target [0.03%]
DNA损伤反应的重要组成及潜在抗癌靶点GADD45蛋白质家族
Kirti S Prabhu,Lubna Therachiyil,Tariq Masoodi et al.
Kirti S Prabhu et al.
Introduction: The Growth Arrest and DNA Damage-Inducible 45 (GADD45) proteins, including GADD45α, GADD45β, and GADD45γ, play a crucial role in the cellular stress response and maintaining genome stability. These protei...
XPO-1 targeting in chronic lymphocytic leukemia: is there potential for therapeutic strategy? [0.03%]
针对慢性淋巴细胞白血病的XPO-1靶向治疗：有潜在的治疗策略吗？
Nawar Maher,Gianluca Gaidano
Nawar Maher
Identification of target sites in the VHR (DUSP3) enzyme unlocking potential avenues for future sepsis treatment [0.03%]
鉴定VHR(DUSP3)酶靶点为未来潜在的治疗脓毒症途径解锁
Jiaqian Wu,Lutz Tautz
Jiaqian Wu
CDK7 as a New therapeutic target in pancreatic and lung cancer: current evidence and future perspectives [0.03%]
CDK7作为胰腺癌和肺癌治疗新靶点的现有证据与未来前景
Emilia Di Giovanni,Rita Siino,Antonio Russo et al.
Emilia Di Giovanni et al.
Introduction: Cyclin-dependent kinase 7 (CDK7) is a key regulator of transcription and the cell cycle, with its dysregulation linked to tumorigenesis and chemoresistance. CDK7 serves as an unfavorable prognostic marker in...
Unveiling the role of mineralocorticoid receptor antagonists in epilepsy: the intersection of seizures, stress, and neuroinflammation [0.03%]
mineralocorticoid受体拮抗剂与癫痫的关系：癫痫、应激和神经炎症的相互作用
Deepanshu Goyal,Maanvi Dhureja,Puneet Kumar
Deepanshu Goyal
Introduction: Epilepsy often presents numerous comorbidities, including anxiety, depression, and cognitive deficits. Epilepsy is not only restricted to GABA/glutamate imbalance, as researchers are delving more into findin...
Gemma Riesco,Elisabet Vilella
Gemma Riesco