The therapy-induced senescence-associated secretory phenotype and epithelial-mesenchymal transition axis in ovarian cancer: molecular mechanisms and therapeutic opportunities [0.03%]
卵巢癌中的治疗诱导的衰老相关分泌表型和上皮间质转化轴：分子机制和治疗机会
Ruiqi Wang,Dongsheng Shang,Zhigang Tu et al.
Ruiqi Wang et al.
Introduction: Therapy-induced senescence (TIS) is an important response to anticancer treatments in ovarian cancer, which can trigger the senescence-associated secretory phenotype (SASP) that may contribute to epithelial-...
Hepatic T-cell dysfunction in chronic liver disease and hepatocellular carcinoma: a spatial systems immunology framework for precision immunotherapy [0.03%]
慢性肝病和肝细胞癌中的肝脏T细胞功能障碍：精确诊疗的时空系统免疫学框架
Wanvisa Udomsinprasert
Wanvisa Udomsinprasert
Background: Chronic liver diseases, including chronic viral hepatitis, metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma (HCC), are characterized by progressive immune dysreg...
ACK family tyrosine kinases as potential therapeutic targets for cancer [0.03%]
Ack家族酪氨酸激酶作为癌症治疗靶点的潜力
Radhika Mittal,Priya Priya,Jyotirmoy Banerjee et al.
Radhika Mittal et al.
Introduction: The activated Cdc42-associated kinase (ACK) family, comprising TNK1 and ACK1/TNK2, are critical regulators of oncogenic signaling and epigenetic reprogramming. Their unique structural architecture, including...
BCAA metabolic reprogramming identifies BCKDK as a therapeutic target in cancer [0.03%]
BCAA代谢重组鉴定BCKDK是癌症治疗靶点
Zhihan Li,Yuxuan Zhou,Li Zhang et al.
Zhihan Li et al.
Introduction: Branched-chain keto acid dehydrogenase kinase (BCKDK) is a mitochondrial kinase that suppresses branched-chain amino acid (BCAA) oxidative catabolism by phosphorylating and inhibiting the branched-chain α-k...
Olatunbosun Adeoke,Jun-Xu Li
Olatunbosun Adeoke
Breakthroughs in our molecular understanding of therapeutic targets for pulmonary hypertension [0.03%]
肺动脉高压治疗靶点的分子作用机制研究进展
Gerrit Bredeck,Alejandro Cruz-Utrilla,Eduardo Oliver
Gerrit Bredeck
Introduction: Pulmonary hypertension (PH) is characterized by progressive pulmonary vascular remodeling, rising right-ventricular afterload, and eventual maladaptation, which is a major determinant of prognosis. While est...
The PDPK1-RSK2 axis as a potential convergent therapeutic vulnerability in B-cell lymphomas [0.03%]
B细胞淋巴瘤中PDPK1-RSK2轴作为潜在的汇聚性治疗脆弱点
Junya Kuroda,Taku Tsukamoto,Yuji Shimura
Junya Kuroda
Introduction: B-cell lymphomas (BCLs) are the most prevalent group of hematologic cancers, encompassing various subtypes, each with a distinct clinical course shaped by cell of origin, genetics, and etiology. Recent advan...
APE1/Ref-1: multifunctional biology, selective inhibition, and the path to clinical translation [0.03%]
APE1/Ref-1：多种生物学功能、选择性抑制及临床转化路径
Jessica A Occhiuto,Silpa Gampala,Melissa L Fishel et al.
Jessica A Occhiuto et al.
Introduction: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional stress-response regulator that coordinates genome maintenance, redox signaling, RNA biology, and cellular metabolism. Its...
Tailored strategies to overcome third-generation TKI resistance in EGFR-mutated non-small cell lung cancer [0.03%]
克服表皮生长因子受体突变的非小细胞肺癌患者对第三代TKI产生耐药性的策略
Isabella Saporita,Giovanni Farinea,Elisa Lombardi et al.
Isabella Saporita et al.
Introduction: In the era of precision medicine, targeting resistance mechanisms is a rational approach to optimize treatment management based on tumor molecular profiling, with the goal of improving clinical outcomes. How...
5-FU in combination with PARP inhibitor ABT-888 deregulates MGMT-dependent mismatch repair (MMR) pathway in MMR-proficient colorectal cancer stem cells by modulating MGMT/PARP1/MSH6 complex [0.03%]
5-FU联合PARP抑制剂ABT-888通过调节MGMT/PARP1/MSH6复合体在MMR阳性结直肠癌干细胞中扰乱由MGMT调控的错配修复通路
Subarno Paul,Chinmay Das,Subhasmita Bhal et al.
Subarno Paul et al.
Background: Previous study showed the PARP inhibitor ABT-888 potentiates the cytotoxicity of 5-fluorouracil (5-FU) by inhibiting PARP1-mediated mismatch repair (MMR) pathway via MSH6 deregulation in MMR-proficient colorec...