Molecular targeting of CDK9 in oncology therapeutics: avenues for translational impact [0.03%]
CDK9分子靶向在肿瘤治疗中的转化影响途径
Tiyao Liu,Zhongran Liu,Wenjing Wei et al.
Tiyao Liu et al.
Background: Cyclin-dependent kinase 9 (CDK9) is a central regulator of RNA polymerase II elongation and has emerged as a therapeutic target in tumors characterized by transcriptional addiction. Growing interest in selecti...
Assessing the preclinical progress in the therapeutic targeting of axial spondyloarthritis [0.03%]
评估轴向脊柱关节炎治疗靶点的临床前研究进展
Ronan Soudy,Manon Jacoutot,Paul Gervaise et al.
Ronan Soudy et al.
Introduction: Axial spondyloarthritis (SpA) is a chronic inflammatory rheumatism affecting predominantly the axial skeleton and frequently also the peripheral joints, often associated with specific extra-musculoskeletal m...
Interleukin-6 as a therapeutic target in diabetic macular edema: current evidence and future perspectives [0.03%]
糖尿病黄斑水肿中白细胞介素-6的治疗靶点：现有证据和未来展望
Hidetaka Noma,Tatsuya Mimura
Hidetaka Noma
Introduction: Diabetic macular edema (DME) is a major cause of vision loss in diabetic retinopathy. Although anti-vascular endothelial growth factor (VEGF) therapy is the current standard treatment, many patients show inc...
The therapy-induced senescence-associated secretory phenotype and epithelial-mesenchymal transition axis in ovarian cancer: molecular mechanisms and therapeutic opportunities [0.03%]
卵巢癌中的治疗诱导的衰老相关分泌表型和上皮间质转化轴：分子机制和治疗机会
Ruiqi Wang,Dongsheng Shang,Zhigang Tu et al.
Ruiqi Wang et al.
Introduction: Therapy-induced senescence (TIS) is an important response to anticancer treatments in ovarian cancer, which can trigger the senescence-associated secretory phenotype (SASP) that may contribute to epithelial-...
Hepatic T-cell dysfunction in chronic liver disease and hepatocellular carcinoma: a spatial systems immunology framework for precision immunotherapy [0.03%]
慢性肝病和肝细胞癌中的肝脏T细胞功能障碍：精确诊疗的时空系统免疫学框架
Wanvisa Udomsinprasert
Wanvisa Udomsinprasert
Background: Chronic liver diseases, including chronic viral hepatitis, metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma (HCC), are characterized by progressive immune dysreg...
ACK family tyrosine kinases as potential therapeutic targets for cancer [0.03%]
Ack家族酪氨酸激酶作为癌症治疗靶点的潜力
Radhika Mittal,Priya Priya,Jyotirmoy Banerjee et al.
Radhika Mittal et al.
Introduction: The activated Cdc42-associated kinase (ACK) family, comprising TNK1 and ACK1/TNK2, are critical regulators of oncogenic signaling and epigenetic reprogramming. Their unique structural architecture, including...
BCAA metabolic reprogramming identifies BCKDK as a therapeutic target in cancer [0.03%]
BCAA代谢重组鉴定BCKDK是癌症治疗靶点
Zhihan Li,Yuxuan Zhou,Li Zhang et al.
Zhihan Li et al.
Introduction: Branched-chain keto acid dehydrogenase kinase (BCKDK) is a mitochondrial kinase that suppresses branched-chain amino acid (BCAA) oxidative catabolism by phosphorylating and inhibiting the branched-chain α-k...
Olatunbosun Adeoke,Jun-Xu Li
Olatunbosun Adeoke
Breakthroughs in our molecular understanding of therapeutic targets for pulmonary hypertension [0.03%]
肺动脉高压治疗靶点的分子作用机制研究进展
Gerrit Bredeck,Alejandro Cruz-Utrilla,Eduardo Oliver
Gerrit Bredeck
Introduction: Pulmonary hypertension (PH) is characterized by progressive pulmonary vascular remodeling, rising right-ventricular afterload, and eventual maladaptation, which is a major determinant of prognosis. While est...
The PDPK1-RSK2 axis as a potential convergent therapeutic vulnerability in B-cell lymphomas [0.03%]
B细胞淋巴瘤中PDPK1-RSK2轴作为潜在的汇聚性治疗脆弱点
Junya Kuroda,Taku Tsukamoto,Yuji Shimura
Junya Kuroda
Introduction: B-cell lymphomas (BCLs) are the most prevalent group of hematologic cancers, encompassing various subtypes, each with a distinct clinical course shaped by cell of origin, genetics, and etiology. Recent advan...