AQP7 suppresses cell stemness and metastasis by targeting Wnt signaling in basal-like breast cancer [0.03%]
AQP7通过靶向基底样乳腺癌中的Wnt信号通路抑制细胞干性和转移
Danni Li,Xinning Liu,Jinhui Lü et al.
Danni Li et al.
Background: Breast cancer is a leading cause of cancer-related death among women worldwide. Aquaporin 7 (AQP7), a transmembrane protein facilitating the transport of glycerol and/or water across plasma membranes, has been...
Therapeutic targeting LRPPRC-Mediated OXPHOS synthesis for cancer intervention [0.03%]
靶向LRPPRC介导的OXPHOS合成治疗癌症
Yuxin Liang,Lina Wang,Ziyan Yang et al.
Yuxin Liang et al.
Introduction: Oxidative phosphorylation (OXPHOS) is essential for the progression of tumors and their resistance to therapy. Conventional inhibitors of OXPHOS that directly targeting the electron transport chain (ETC) act...
Targeting BUB1B-Driven Cancer stemness in lung adenocarcinoma: a novel therapeutic strategy via PI3K/AKT pathway modulation [0.03%]
靶向肺腺癌中的BUB1B驱动的癌症干细胞性：通过调节PI3K/AKT途径的新治疗策略
RuiXue Gu,Ge Li,LongHao Wang et al.
RuiXue Gu et al.
Background: Tumor stemness is a key driver of therapeutic resistance and malignant progression in lung adenocarcinoma (LUAD), but its molecular basis and clinical significance remain unclear. This study explores the tumor...
Understanding how bacterial cell wall peptidoglycan metabolism can be used to develop antimicrobial strategies [0.03%]
细菌细胞壁肽聚糖代谢在抗菌策略中的作用及应用机制研究
Emma Melotti,Thomas Delerue,Ivo Gomperts Boneca
Emma Melotti
Introduction: Despite the fact that the progress in developing new antibiotics with novel mechanism of action is limited owing to the considerable challenges involved and the modest financial returns, we are urgently need...
Sugars to signals: emerging roles of PAK1 in Re-wiring glucose metabolism in cancers [0.03%]
糖变信号：PAK1在重编程肿瘤代谢中的新角色
Prarthana Gopinath,Srikanth Swamy Swaroop B,Ganesh Venkatraman et al.
Prarthana Gopinath et al.
p21-activated kinase 1 (PAK1) is a critical serine/threonine kinase involved in regulating key cellular processes driving cancer progression. While PAK1 is well-known for its contributions to the hallmarks of cancer - such as sustained prol...
Yogitha S Chareddy,Chad V Pecot
Yogitha S Chareddy
Paraspeckle component 1 in acute myeloid leukemia: prospects for therapeutic targeting [0.03%]
急性髓系白血病中的寄生斑成分1：治疗靶向的前景
Mingjiang Xu,Jianlong Wang
Mingjiang Xu
Targeting the activation heat shock proteins for the potential treatment of neurodegenerative disease [0.03%]
靶向激活热休克蛋白以潜在治疗神经退行性疾病
Anita K Ho,Han-Jou Chen
Anita K Ho
Critical evaluation of therapeutic targeting in chronic kidney disease: where do we stand 5 years on? [0.03%]
慢性肾脏病治疗靶点的批判性评价：五年后的现状如何？
Mario Cozzolino,Lorenza Magagnoli,Paola Ciceri
Mario Cozzolino
Advancements in the molecular understanding of major depressive disorder uncovering novel targets with therapeutic promise: focus on recurrence of illness [0.03%]
抑郁症分子机理研究的新进展发现有治疗潜力的新的药物靶点：重点关注疾病的复发
Michael Maes,Abbas F Almulla,Drozdstoj Stoyanov et al.
Michael Maes et al.
Introduction: Major depressive disorder (MDD) is a neuro-immune-metabolic-oxidative stress (NIMETOX) disorder. A significant proportion (50%) of individuals with MDD experience recurrence of episodes and suicidal behavior...