Targeting PICK1 in drug discovery: from PDZ inhibition to next-generation BAR and Bivalent modalities [0.03%]
靶向PICK1药物研发：从PDZ抑制到下一代BAR和双模态研究
Emily Hendrix,Yi He
Emily Hendrix
Bidirectional nexus between metabolic disease and aortic valve calcification: from pathogenic mechanisms to integrated multimorbidity management [0.03%]
代谢性疾病与主动脉瓣钙化之间的双向联系：从致病机制到综合多发病管理
Xinyue Wang,Mincheng Yu,Jingzheng Chen et al.
Xinyue Wang et al.
Introduction: Calcified aortic valve disease (CAVD) imposes a severe global health burden, and there is currently no effective pharmacotherapy, which urgently requires a new understanding of pathophysiology to guide treat...
Molecular targets in gastric cancer for Nanomedicine therapeutics: mechanistic insights and Translational progress [0.03%]
纳米药物治疗在胃癌分子靶点中的作用：机制见解和转化进展
Mohd Saeed,Taha Alqahtani,Humood Al Shmrany et al.
Mohd Saeed et al.
Introduction: Gastric cancer remains a leading cause of cancer mortality due to late diagnosis, aggressive progression, and limited treatment response. Nanomedicine offers promising avenues to exploit molecular targets an...
Molecular basis for targeting caveolin-1 in multiple myeloma therapy [0.03%]
针对多发性骨髓瘤治疗靶向 Caveolin-1 的分子机制
Dewen Zhan,Kim De Veirman,Yuhe Guan et al.
Dewen Zhan et al.
Introduction: Multiple myeloma (MM) is a plasma cell malignancy characterized by frequent relapse and resistance to therapy. Caveolin-1 (Cav-1), a scaffolding protein that forms plasma membrane caveolae, has been demonstr...
MicroRNA-96 inhibition retarded the progression of atherosclerotic plaques via FOXO1/CYP7A1 mediated cholesterol-bile acid metabolism pathway [0.03%]
microRNA-96抑制通过FOXO1/CYP7A1介导的胆固醇-胆汁酸代谢通路延缓动脉粥样硬化斑块进展
Li Wang,Yiting Liu,Jin Zhang et al.
Li Wang et al.
Background: Conversion of cholesterol into bile acids is a central pathway for cholesterol disposal, which was mainly controlled by cholesterol 7alpha-hydroxylase (Cyp7a1). In present study, we aimed to investigate the ef...
Modulating tonic NMDA receptor currents: mechanistic insights into ketamine, Esketamine and dextromethorphan for major depressive disorder and implications for the discovery and development of investigational agents [0.03%]
调节基线NMDA受体电流：酮胺、艾司氯胺酮及右美沙芬治疗抑郁症的机制见解及其对研究性药物发现和开发的意义
Gia Han Le,Roger S McIntyre
Gia Han Le
Introduction: Up to 50% of adults with major depressive disorder (MDD) fail to achieve remission after two or more monoaminergic antidepressants and meet criteria for treatment-resistant depression (TRD). Low-dose intrave...
The Werner syndrome RECQ helicase as a therapeutic target: new insights [0.03%]
Werner综合征RECQ解旋酶作为治疗靶点：新见解
Julia M Sidorova,Raymond J Monnat Jr
Julia M Sidorova
Areas covered: we discuss WRN as a caretaker of the genome that can function as a tumor suppressor or tumor enabler, and review progress on targeting functional WRN in microsatellite-unstable (MSI) cancers. We discuss mec...
The IL-33 receptor ST2 as a therapeutic target for hemophilic arthropathy [0.03%]
ST2(IL-33受体)是血友病关节病的治疗靶点
Alexander G Lawrence,James S O&#x;Donnell,Peter L Turecek et al.
Alexander G Lawrence et al.
Blocking glycan production by targeting GALNT7 for prostate cancer therapy [0.03%]
通过靶向GALNT7抑制糖链生成用于前列腺癌治疗
Ziqian Peng,Kirsty Hodgson,Margarita Orozco-Moreno et al.
Ziqian Peng et al.
Zachary Freyberg,Mary M Torregrossa,Emily M Rocha
Zachary Freyberg
Introduction: Parkinson's disease is among the most common age-related neurodegenerative disorders today and characterized by midbrain dopamine neuron degeneration. However, this cell loss is not uniform. Though most dopa...