Lipopolysaccharide-targeting treatments for multidrug-resistant Pseudomonas aeruginosa [0.03%]
脂多糖靶向治疗耐多药铜绿假单胞菌感染的新策略
Meggie Wang,Natalia V Kirienko
Meggie Wang
Introduction: Pseudomonas aeruginosa is an opportunistic, nosocomial, Gram-negative pathogen implicated in a wide variety of infection types and is especially problematic in chronic lung infections for patients with cysti...
Uncovering targets and molecular pathways for personalizing treatment in epilepsy [0.03%]
揭示癫痫个性化治疗的作用靶点和分子通路
Filip Rosa,Holger Lerche
Filip Rosa
Introduction: Despite licensing of many new antiseizure drugs over the last few decades, the proportion of pharmacoresistant epileptic seizures has remained largely unchanged at about 30%. However, recent progress in gene...
Hide and seek: targeting nuclear receptor PXR with inhibitors and PROTACs to improve drug efficacy and safety [0.03%]
躲猫猫：用抑制剂和PROTACs靶向核受体PXR以提高药物的疗效和安全性
Andrew D Huber,Taosheng Chen
Andrew D Huber
Feasibility of remnant cholesterol as a therapeutic target for atherosclerotic cardio-vascular disease [0.03%]
残留胆固醇作为动脉粥样硬化性心血管疾病治疗靶点的可能性评估
Anders Berg Wulff,Anette Varbo,Ask Tybjærg Nordestgaard et al.
Anders Berg Wulff et al.
Introduction: Elevated plasma concentration of remnant cholesterol, the cholesterol in triglyceride-rich lipoproteins, is associated with increased risk of atherosclerotic cardiovascular disease(ASCVD) in large observatio...
Novel therapeutic targets for abdominal aortic aneurysm treatment: evidence from recent preclinical research [0.03%]
近期基础研究发现的新型腹主动脉瘤治疗靶点
Shivshankar Thanigaimani,Jonathan Golledge
Shivshankar Thanigaimani
Introduction: The absence of any treatment for small abdominal aortic aneurysm (AAA) highlights the urgent need for an effective drug therapy. Areas cover...
YAP1 signalling and cancer: molecular pathways reveal novel targeting opportunities [0.03%]
YAP1信号转导与癌症：分子通路揭示了新的治疗思路
Jialin Wu,Bonan Chen,Fuda Xie et al.
Jialin Wu et al.
Introduction: The Hippo pathway plays a critical role in maintaining tissue homeostasis, regulating organ size, and controlling cellular processes. YAP1/TAZ activation drives oncogenesis, metastasis, and resistance to che...
Uncovering potential targets for MRSA infection treatment: a nanomedicine perspective [0.03%]
从纳米医药角度看MRSA感染治疗的潜在靶点研究
Eman A Ismail,Abdelrahman Tageldin,Mohammed A Gafar et al.
Eman A Ismail et al.
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) remains a formidable global health challenge, responsible for severe infections with unacceptably high mortality rates. Conventional antibiotics, though ess...
Therapeutic potential for glial derived octadecaneuropeptide in the treatment of obesity [0.03%]
神经肽治疗肥胖的潜在疗效研究
Oleksandr Orativskyi,Caroline E Geisler,Matthew R Hayes et al.
Oleksandr Orativskyi et al.
Functional roles of microRNAs in pancreatic islet autoimmunity: what do we know and where do we target? [0.03%]
microRNA在胰岛自身免疫中的作用机制：我们已经知道什么？未来的方向又在哪里？
Giuseppina Emanuela Grieco,Laura Nigi,Guido Sebastiani et al.
Giuseppina Emanuela Grieco et al.
Introduction: Type 1 diabetes (T1D) results from a destructive dialogue between stressed pancreatic beta-cells and immune system. While current disease-modifying approaches targeting these processes are being developed an...
Bridging neurotransmission and tumor biology: the emerging focus on CHRM1 in skin cancer therapy [0.03%]
连结神经传递和肿瘤生物学：CHRM1在皮肤癌治疗中的新兴焦点
Dhruv Sharma,Aniruddha Roy,Durga Dharmadana et al.
Dhruv Sharma et al.
Introduction: Skin cancer is one of the most prevalent types of cancers and has shown an upward trend recently. Among various types, melanoma skin cancer is known to be the most dangerous, exhibiting resistance to treatme...