P2 receptors as emerging therapeutic targets in neglected parasitic diseases [0.03%]
P2受体作为被忽视的寄生虫病的治疗靶点
Mariana M Chaves,Nayara Carvalho-Barbosa,Luiz Eduardo Baggio Savio et al.
Mariana M Chaves et al.
Introduction: Despite sustained control efforts, neglected parasitic diseases, such as malaria, leishmaniasis, Chagas disease, schistosomiasis, and toxoplasmosis, continue to exert a substantial global burden, driven by h...
Advances in CGRP therapeutic targets for migraine: where do we stand 5 years later? [0.03%]
降钙素基因相关肽在偏头痛中的研究进展——五年回顾
Adriana Della Pietra,Andrew F Russo
Adriana Della Pietra
Introduction: The past five years of success with calcitonin gene-related peptide (CGRP) based drugs has transformed migraine into a relatively treatable neurological disorder. There are now eight monoclonal antibodies an...
Targets of senescence in cardiac muscle: insights for regenerative treatments in the aged heart [0.03%]
衰老心脏再生治疗中肌细胞衰老靶点的启示
Georgina M Ellison-Hughes,Daniele Torella
Georgina M Ellison-Hughes
Introduction: Despite considerable investment of time and funding, advancement in cardiac regenerative therapies has been slow. Results of large animal and human studies have failed to live up to the expectations of the p...
Molecular insights into the PRLR-Hippo-YAP axis in breast cancer therapeutics [0.03%]
乳腺癌治疗中PRLR-Hippo-YAP轴的分子见解
Suhad Ali,Jean-Jacques Lebrun
Suhad Ali
Advancing our understanding of molecular targets for hepatic ischemia-reperfusion injury therapy [0.03%]
肝缺血再灌注损伤治疗的分子靶点研究进展
Siyuan Yao,Jerzy W Kupiec-Weglinski
Siyuan Yao
Introduction: Hepatic ischemia-reperfusion injury (IRI) remains a challenge in liver transplantation (LT), particularly with the increasing utilization of marginal grafts. Driven by ischemic stress and hemodynamic instabi...
Promise of ANGPTL3 as a therapeutic target for controlling cholesterol levels [0.03%]
ANGPTL3作为控制胆固醇水平的治疗靶点的潜力
Robert A Hegele
Robert A Hegele
Introduction: Angiopoietin-like protein 3 (ANGPTL3) has emerged over the past decade as one of the most intriguing therapeutic targets in lipid metabolism. ...
The emerging endogenous peptide Apelin 13 in diabetes and its related complications: a narrative review [0.03%]
阿皮林肽13在糖尿病及其相关并发症中的作用及机制：述评
Saurav Singla,Uma Jyoti,Thakur Gurjeet Singh et al.
Saurav Singla et al.
Introduction: Apelin-13, an active peptide in the apelinergic system, is essential for glucose regulation, insulin sensitivity, and vascular homeostasis. Its significance lies in its ability to manage diabetes and its con...
Katsuhiro Nakanishi,Kaito Yukishima,Eiji Umemoto
Katsuhiro Nakanishi
IGFBP-6 as a potential therapeutic target in musculoskeletal disorders [0.03%]
骨关节疾病潜在治疗靶点胰岛素样生长因子结合蛋白6的研究进展
Margherita Maranesi,Giulia Cenci,Pierluigi Antinolfi et al.
Margherita Maranesi et al.
Introduction: Insulin-like Growth Factor Binding Protein 6 (IGFBP-6) is a member of the IGFBP family with unique and relevant biological properties. Emerging evidence suggests that IGFBP-6 plays a critical role in musculo...