Investigating metabotropic glutamate receptors as molecular targets for next-generation pharmacotherapies for alcohol use disorder [0.03%]
探究代谢型谷氨酸受体作为酒精使用障碍下一代药物治疗分子靶点的可能性研究
Dominic Obraitis,Jason Barry,Dawei Li
Dominic Obraitis
Introduction: Alcohol use disorder (AUD) is a major public health concern with few available pharmacotherapy options. There remains a critical need to identify novel molecular targets for more effective treatments. Eviden...
Key principles and guidance for the development of lncRNA targeting cancer therapeutics [0.03%]
靶向癌症治疗的lncRNA研发关键原则和指导意见
Waleed H Almalki
Waleed H Almalki
Introduction: Long non-coding RNAs (lncRNAs) have emerged as critical regulators of gene expression and cellular behavior in cancer, influencing tumor initiation, progression, metastasis, and therapeutic resistance. Their...
Identifying targets at the blood-brain barrier for treating vascular cognitive impairment and dementia [0.03%]
用于治疗血管性认知障碍和痴呆的血脑屏障靶点鉴定
Adnan Akif,Thi Thanh My Nguyen,Benjamin L Hao et al.
Adnan Akif et al.
Introduction: Vascular cognitive impairment and dementia (VCID) arise from chronic cerebrovascular dysfunction that compromises the blood-brain barrier (BBB), a critical interface maintaining neural homeostasis. The BBB's...
Targeting the NLRP3 inflammasome with antibody-based Therapeutics for chronic neurodegenerative diseases [0.03%]
基于抗体的针对神经退行性疾病中NLRP3炎性小体的治疗
Jagdeep K Sandhu,Jamshid Tanha,Mehdi Arbabi-Ghahroudi
Jagdeep K Sandhu
Introduction: The NLRP3 inflammasome is a central regulator of innate immunity that becomes aberrantly activated by amyloid-β, hyperphosphorylated tau, and α-synuclein aggregates in chronic neurodegenerative diseases su...
Targeting the OPA1 pathway in Autosomal Dominant Optic Atrophy (ADOA): 25 years from gene discovery to therapeutic strategy [0.03%]
靶向OPA1通路治疗遗传性视神经萎缩：从基因发现至治疗方法的25年进展
Marcel V Alavi
Marcel V Alavi
Introduction: Autosomal Dominant Optic Atrophy (ADOA) is a rare hereditary optic neuropathy primarily caused by OPA1 mutations. Retinal ganglion cell (RGC) loss results in variable visual impairments, occasionally accompa...
Relevance of lipid droplets in metabolic dysfunction-associated steatotic liver disease [0.03%]
脂滴在代谢功能障碍相关性肝脂肪变性疾病中的作用
Ralf Weiskirchen,Amedeo Lonardo
Ralf Weiskirchen
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally, leading to cirrhosis, hepatocellular carcinoma, and increased liver-related mortality, alon...
Molecular-level host-microbe interactions: mechanisms, molecules, and modeling toward precision probiotics [0.03%]
分子水平的宿主-微生物相互作用：机制、分子和建模，以实现精准益生菌
Huan Zhang,Shiqi Zhang,Jiangjiang Zhu
Huan Zhang
Introduction: Advancing next-generation probiotics (NGPs) as precision therapeutics depends on a detailed understanding of host - microbe molecular interactions, as these organisms exert targeted effects through defined b...
The role of human complement factor H in retinal immune response and the prospects for targeted therapy for age-related macular degeneration (AMD) [0.03%]
补体因子H在视网膜免疫反应中的作用及年龄相关性黄斑变性的靶向治疗展望
Anne Wolf,Thomas Clahsen,Thomas Langmann
Anne Wolf
Molecular understanding for therapeutic targeting of hypoxia in breast cancer [0.03%]
乳腺癌治疗中的低氧分子机制及靶向治疗研究
Andrea Angeli,Claudiu T Supuran
Andrea Angeli
Introduction: Breast cancer is one of the most widespread types of cancer, affecting millions of patients worldwide and although significant advances in its therapy have been achieved in the last decades, a large number o...
An overview of outer membrane protein A (OmpA) as a therapeutic target for Acinetobacter baumannii infection [0.03%]
肠杆菌属baumannii感染的治疗靶点外膜蛋白A(OmpA)研究概述
Md Minarul Islam,Man Hwan Oh,Woo Shik Shin et al.
Md Minarul Islam et al.
Introduction: The rapid dissemination of drug-resistant Acinetobacter baumannii strains has severely limited available therapeutic options, highlighting the urgent need for novel or alternative treatment strategies. ...