Transient receptor potential (TRP) channels: an emerging therapeutic target for the treatment of cardiac hypertrophy [0.03%]
瞬时受体电位(TRP)通道：治疗心脏肥厚的新兴治疗靶点
Saumya Upadhyay,Shyam Sunder Sharma
Saumya Upadhyay
Introduction: Cardiac hypertrophy (CH) is a major contributor to cardiovascular disease (CVD), affecting millions worldwide. While initially an adaptive response, sustained hypertrophic stimuli lead to maladaptive outcome...
The AT2 receptor as a potential target for autosomal dominant polycystic kidney disease therapy? [0.03%]
AT2受体可能是常染色体显性多囊肾病治疗的潜在靶标？
Yan Wang,Sharon Ricardo,Robert Widdop
Yan Wang
Therapeutic activation of the endocannabinoid system for opioid use disorder, chronic pain, and cancer-related pain: a review of current evidence [0.03%]
阿片类物质使用障碍、慢性疼痛和癌痛的治疗性激活内源大麻素系统疗法：现有证据综述
Oluseun Dairo,Jocelyn A Mitchell-Williams,Ping Zhang
Oluseun Dairo
Introduction: Opioid use disorder (OUD) and chronic pain are major global health challenges. Although opioid therapies provide effective analgesia, long-term use is limited by safety concerns, dependence, and variable eff...
The protective role of SIRT1 in cardiovascular disease: from molecular mechanisms to potential therapeutic strategies [0.03%]
SIRT1在心血管疾病中的保护作用：从分子机制到潜在治疗策略
Haixin Ma,Shuya Wang,Zijian Dang et al.
Haixin Ma et al.
Introduction: Cardiovascular diseases (CVDs) pose a significant threat to the health of middle-aged and elderly people. They are widely recognized as a major public health concern. The sirtuin (SIRT) family comprises seve...
Targeting inflammatory persistence in axial spondyloarthritis: from cytokine blockade to pathway convergence [0.03%]
靶向轴型脊柱关节炎的炎症持续性：从细胞因子阻断到途径会聚
Dimitrios Deligeorgakis,Nikolaos Kougkas
Dimitrios Deligeorgakis
Therapeutic targeting of DNA repair pathway dysregulation in aging, cancer, and neurodegeneration [0.03%]
针对衰老、癌症和神经退行性疾病中DNA修复途径失调的治疗靶向作用
Vipin Kumar,Mohmmad Kashif,Vivek Singh et al.
Vipin Kumar et al.
Introduction: Genome maintenance is increasingly recognized as a shared vulnerability across aging, cancer, and neurodegeneration, yet the therapeutic implications of pathway-specific dysregulation of DNA repair remain in...
RNA-centric approaches in amyotrophic lateral sclerosis: prospects for future therapeutics [0.03%]
以RNA为中心的肌萎缩侧索硬化症研究方法：未来治疗前景
Valentina La Cognata,Giulia Gentile,Giovanna Morello et al.
Valentina La Cognata et al.
Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by profound clinical and molecular heterogeneity, which has substantially hindered the development of effective therapi...
Insights into the therapeutic targeting of ASIC3 in pain: hurdles for clinical development [0.03%]
酸敏感离子通道3在疼痛治疗中的研究进展及临床开发的挑战
Chih-Hung Chi,Cheng-Han Lee,Chih-Cheng Chen
Chih-Hung Chi
Introduction: Acid-sensing ion channel 3 (ASIC3) is a promising therapeutic target for pain because of its unique peripheral expression profile in somatosensory neurons and channel properties for sensing mild extracellula...
Emergent RNA targets in cardiovascular disease: likely candidates for treatment development [0.03%]
心血管疾病中新兴的RNA治疗靶点：可能用于药物开发的候选者
Veronica Barbi,Maria Anele Romeo,Michela Gottardi Zamperla et al.
Veronica Barbi et al.
Introduction: Cardiovascular diseases (CVDs) are a leading cause of morbidity and death worldwide, emphasizing the urgent need for innovative diagnostic and treatment strategies. Increasing evidence indicates that noncodi...
From supportive to targeted treatment strategies: the changing landscape of therapeutics in Alagille syndrome [0.03%]
从支持性治疗到特异性治疗策略：Alagille综合征治疗领域的新格局
Kavitha Anbarasu,Melissa A Gilbert,Kathleen M Loomes
Kavitha Anbarasu