APE1/Ref-1: multifunctional biology, selective inhibition, and the path to clinical translation [0.03%]
APE1/Ref-1：多种生物学功能、选择性抑制及临床转化路径
Jessica A Occhiuto,Silpa Gampala,Melissa L Fishel et al.
Jessica A Occhiuto et al.
Introduction: Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional stress-response regulator that coordinates genome maintenance, redox signaling, RNA biology, and cellular metabolism. Its...
Tailored strategies to overcome third-generation TKI resistance in EGFR-mutated non-small cell lung cancer [0.03%]
克服表皮生长因子受体突变的非小细胞肺癌患者对第三代TKI产生耐药性的策略
Isabella Saporita,Giovanni Farinea,Elisa Lombardi et al.
Isabella Saporita et al.
Introduction: In the era of precision medicine, targeting resistance mechanisms is a rational approach to optimize treatment management based on tumor molecular profiling, with the goal of improving clinical outcomes. How...
5-FU in combination with PARP inhibitor ABT-888 deregulates MGMT-dependent mismatch repair (MMR) pathway in MMR-proficient colorectal cancer stem cells by modulating MGMT/PARP1/MSH6 complex [0.03%]
5-FU联合PARP抑制剂ABT-888通过调节MGMT/PARP1/MSH6复合体在MMR阳性结直肠癌干细胞中扰乱由MGMT调控的错配修复通路
Subarno Paul,Chinmay Das,Subhasmita Bhal et al.
Subarno Paul et al.
Background: Previous study showed the PARP inhibitor ABT-888 potentiates the cytotoxicity of 5-fluorouracil (5-FU) by inhibiting PARP1-mediated mismatch repair (MMR) pathway via MSH6 deregulation in MMR-proficient colorec...
Possibility to therapeutically exploit RGPR-p117 as a target in cancer cells [0.03%]
RGPR-p117可能是癌细胞治疗性靶标的可能性研究
Masayoshi Yamaguchi
Masayoshi Yamaguchi
Introduction: RGPR-p117 was identified as a transcription factor that binds to the TTGGC(N)6CC sequence in the promoter region of the regucalcin gene, a tumor suppressor. This article discusses the therapeutic potential o...
The evolving bioinformatic approaches to identifying genetic targets of promise in cancers [0.03%]
癌症中具有前景的遗传目标的生物信息学方法的发展与演变
Vijay Kumar,Darin Mansor Mathkor,Shafiul Haque
Vijay Kumar
Introduction: The search for actionable genetic targets in cancer has evolved substantially over the past decade. Earlier approaches were focused on single genes or individual molecular alterations, but this is insufficie...
Fibroblast activation protein inhibitor-based theranostics in neuroendocrine neoplasms [0.03%]
基于成纤维细胞活化蛋白抑制剂的神经内分泌肿瘤诊疗一体化研究
Anna La Salvia,Daniela Lucente,Stefania Bellino
Anna La Salvia
The biological role of CCR4 and its ligands CCL17 and CCL22 in atopic dermatitis: therapeutic implications and future directions [0.03%]
趋化因子受体CCR4及其配体CCL17和CCL22在特应性皮炎中发挥的生物学作用：治疗意义及未来方向研究进展
Dante Dahabreh,Dev Patel,Ester Del Duca et al.
Dante Dahabreh et al.
Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disorder driven by Th2-related cytokines, including interleukin-4 (IL-4) and IL-13. Recent single-cell sequencing and proteomic studies have demonstrated...
Yusuke Inoue
Yusuke Inoue
The role of bile acid receptors in cholestatic liver disease: pathophysiological insights and therapeutic advances [0.03%]
胆汁酸受体在肝内胆汁淤积性疾病中作用的病理生理学见解及治疗进展
Hongying Zhou,Jie Yang,Wenbin Wu et al.
Hongying Zhou et al.
Introduction: Cholestatic liver disease (CLD) is a group of hepatobiliary disorders characterized by impaired bile flow, leading to the accumulation of toxic bile acids (BAs) and progressive liver injury. The available ph...
Molecular insights for targeting the Nrf1 pathway in hepatocellular carcinoma [0.03%]
靶向Nrf1通路的肝细胞癌分子见解
Xi Chen,Zhengwen Zhang,Siqian Cui et al.
Xi Chen et al.
Introduction: Nuclear factor erythroid 2-related factor 1 (Nrf1, encoded by NFE2L1) plays a central role in maintaining cellular homeostasis, basal redox balance, and mitochondrial quality control and its function. Recent...