Triple negative breast cancer chemosensitivity and chemoresistance: current advances in biomarkers indentification [0.03%]
三阴性乳腺癌的化疗敏感性和耐药性的当前研究进展：分子标志物识别方面的突破
Fouzia Guestini,Keely May McNamara,Takanori Ishida et al.
Fouzia Guestini et al.
Introduction: Triple negative breast cancer (TNBC) is a heterogeneous clinicopathological entity constituting approximately 15 - 20% of all breast cancer (BC) patients. It shows high recurrence rate and poor prognosis. At...
Lisa Yang,Waljit Dhillo
Lisa Yang
Introduction: Kisspeptins are a family of neuropeptides whose identification has become one of the biggest discoveries in reproductive endocrinology during the past decade. Kisspeptins act upstream of GnRH as high-level m...
Shin Takasawa
Shin Takasawa
Introduction: The regenerating gene (Reg) was identified in regenerating islets and its related genes were revealed to constitute the Reg gene family. Reg family proteins act as growth factors for several cells. Recently,...
Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function [0.03%]
最近胆盐出口泵(BSEP/ABCB11)功能探索研究进展
Ágnes Telbisz,László Homolya
Ágnes Telbisz
Introduction: The bile salt export pump (BSEP/ABCB11), residing in the apical membrane of hepatocyte, mediates the secretion of bile salts into the bile. A range of human diseases is associated with the malfunction of BSE...
Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation [0.03%]
针对神经退行性疾病小胶质细胞的治疗范式转换：从抗炎策略到主动免疫调节
Emiliano Peña-Altamira,Federica Prati,Francesca Massenzio et al.
Emiliano Peña-Altamira et al.
Introduction: The importance of microglia in most neurodegenerative pathologies, from Parkinson's disease to amyotrophic lateral sclerosis and Alzheimer's disease, is increasingly recognized. Until few years ago, microgli...
Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma [0.03%]
AMPK信号在白杨素介导抗食道鳞状细胞癌增生的作用中的作用研究
Jin Li,Bin Li,Wen Wen Xu et al.
Jin Li et al.
Objective: Emerging evidence suggests that activation of adenosine monophosphate-activated protein kinase (AMPK) may suppress cancer growth. Identification of novel AMPK activators is therefore crucial to exploit AMPK as ...
Muhammad Shamoon,Yuanyuan Deng,Yong Q Chen et al.
Muhammad Shamoon et al.
Introduction: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas encompassing a cascade of cellular and molecular events. It starts from premature activation of zymogens with the involvement of innate imm...
Can M Ünal,Michael Steinert
Can M Ünal
Introduction: In recent years, Clostridium difficile has become the primary cause of antibiotic-associated diarrhea and pseudomembranous colitis, resulting in long and complicated hospital stays that represent a serious b...
Giorgio Cozza,Lorenzo A Pinna
Giorgio Cozza
Introduction: The conventional term 'casein kinase' (CK) denotes three classes of kinases - CK1, CK2 and Golgi-CK (G-CK)/Fam20C (family with sequence similarity 20, member C) - sharing the ability to phoshorylate casein i...
Dabin Ren,Michael E Pichichero
Dabin Ren
Introduction: Moraxella catarrhalis is a prominent pathogen that causes acute otitis media in children and lower respiratory tract infections in adults, resulting in a significant socioeconomic burden on healthcare system...