Identifying protease-activated targets and exploring therapeutic applications [0.03%]
识别丝氨酸蛋白酶激活的靶点及探索其在疾病治疗中的应用
Deokhee Kang,Charles S Craik
Deokhee Kang
Introduction: Proteases are essential enzymes that regulate protein turnover and activate signaling pathways through targeted peptide bond cleavage. While traditionally regarded as degradative agents, proteases are now re...
Meichen Zhang,Yongqi Lin,Huanhuan Wei et al.
Meichen Zhang et al.
Introduction: With the increasing prevalence of aging populations, the incidence of neurodegenerative diseases continues to rise, posing a serious threat to human health and quality of life. Owing to the highly complex pa...
The contribution of fibronectin in epileptogenesis: therapeutic potential and mechanistic complexity [0.03%]
纤维连接蛋白在癫痫发病机制中的作用：治疗潜力与机制复杂性
Neha Dixit,Nitin Yadav,Priya et al.
Neha Dixit et al.
Introduction: Epilepsy is a chronic neurological disorder leading to repeateduncontrollable seizures. The available armamentarium of ~ 30 antiseizure drugsis unable to control seizures in a third of the patients, which si...
Targeting activin E: insights in to role in adipose tissue and prospects for weight loss therapeutic development [0.03%]
激活素E的作用靶点：在脂肪组织中的作用机制及其减肥治疗前景的启示
Osamu Hashimoto,Maho Sakaki
Osamu Hashimoto
Disrupting Siglec-mediated interactions to develop immunotherapies for cancer treatment [0.03%]
通过干扰Siglec介导的相互作用来开发癌症免疫治疗药物
Heinz Läubli,Ajit Varki
Heinz Läubli
Introduction: Recent advances in cancer immunotherapy have improved patient outcomes, even in advanced stages of the disease. However, the effectiveness of current cancer immunotherapies remains limited to a small subset ...
The potential of thromboxane A₂ as a therapeutic target: prospects and challenges [0.03%]
血栓素A2的治疗潜力：前景与挑战
Ralf A Benndorf
Ralf A Benndorf
The molecular role of RE1 silencing transcription factor in uterine diseases: is there potential for targeted therapeutic development? [0.03%]
RE1沉默转录因子在子宫疾病中的分子作用：是否有靶向治疗开发的潜力？
Warren B Nothnick,Vargheese Chennathukuzhi
Warren B Nothnick
Precision targeting of the melanocortin-1 receptor with radiopharmaceuticals in metastatic melanoma [0.03%]
放射性药物精准靶向黑色素瘤转移灶中的黑皮质素1受体
Hiroyuki Suzuki,Tomoya Uehara
Hiroyuki Suzuki
Role of serotonin in the neurobiology of attention-deficit/hyperactivity disorder: a systematic literature review [0.03%]
五羟色胺在注意缺陷多动障碍神经生物学中的作用：系统文献综述
Stephen V Faraone,Caroline L Ward,Matthieu Boucher et al.
Stephen V Faraone et al.
Introduction: Attention-deficit/hyperactivity disorder (ADHD) is a common neuropsychiatric disorder of inattention, hyperactivity, and impulsivity. Roles for dopamine and norepinephrine are widely recognized; however, the...
Rhabdomyosarcoma: development of molecular therapeutics under the microscope [0.03%]
横纹肌肉瘤的个体化医疗：分子靶向治疗的发展现状与未来展望
Peter J Houghton,Mary-Ann Bjornsti
Peter J Houghton
Introduction: Rhabdomyosarcoma (RMS), predominantly diagnosed in children, represents 3% of pediatric solid tumors. RMS has characteristics of skeletal muscle, although the cell of origin remains controversial. Cytotoxic ...