Sex and gender differences in the effects of immunosuppressive drugs in patients with kidney transplantation [0.03%]
免疫抑制药的性别差异及其对肾移植患者的影响
Claudia Lo Re,Elisa Longhitano,Guido Gembillo et al.
Claudia Lo Re et al.
Introduction: Kidney transplantation requires lifelong immunosuppressive therapy, yet substantial interindividual variability in drug exposure and toxicity remains a major clinical challenge. Emerging evidence indicates t...
Sara Iannuzzi,Lanxin Zhang,Antonia Liebenberg et al.
Sara Iannuzzi et al.
Introduction: Soon after their discovery, antiretroviral drugs were used for post-exposure prophylaxis (PEP) and soon after that for preventing mother-to-child transmission (MTCT) of HIV. About fifteen years ago, they wer...
GLP-1RA PHARMACOKINETICS AND CLINICAL EFFECTS: FOCUS ON CARDIAC, VASCULAR, AND GLOMERULAR STRUCTURES [0.03%]
GLP-1受体激动剂的药代动力学和临床效应：关注心脏、血管及肾小球结构
Ivano Barnaba,Francesco Massari,Marco Matteo Ciccone et al.
Ivano Barnaba et al.
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1RA) have emerged as key drug class in the management of the cardio-nephro-metabolic continuum. Their effects extend to cardiac, vascular, and renal systems, pr...
Inavolisib: a second-generation PI3Kα inhibitor in HR+/HER2-negative breast cancer [0.03%]
Ipatolisib：HR+/HER2阴性乳腺癌PI3Kα抑制剂的二代产品
Elaria Abdy,Jean-Pierre Betancourt,Supratik Kar
Elaria Abdy
Introduction: Hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer is the most common subtype, yet resistance to therapy remains a major clinical challenge. Up to 40% of pa...
Ivy Antwi,Theodore J Cory
Ivy Antwi
Introduction: Depression is common among people living with HIV and is often linked to poorer adherence, disease progression, and quality of life. The widespread use of lifelong antiretroviral therapy alongside antidepres...
Thomas Hartung
Thomas Hartung
An update on beta-lactam-beta-lactamase inhibitor combinations for the treatment of carbapenem-resistant gram-negative pathogens [0.03%]
β内酰胺- β内酰胺酶抑制剂联合疗法治疗碳青霉烯类耐药革兰阴性病原体的最新研究进展
Ilias Karaiskos,Aikaterini Gkoufa,Eudoxia Kyriazopoulou et al.
Ilias Karaiskos et al.
Introduction: Carbapenem-resistant Gram-negative bacteria represent a major global health threat driven by diverse β-lactamase enzymes, particularly KPC, metallo-β-lactamases, and OXA-type carbapenemases, leading to lim...
Optimizing tamoxifen therapy in breast cancer: a narrative review of dose escalation in patients with CYP2D6 polymorphisms [0.03%]
乳腺癌他莫昔芬治疗的优化：CYP2D6多态性患者的剂量递增叙事综述
Juliana Henrique Duarte,Jose Claudio Casali-da-Rocha,Rafael Linden et al.
Juliana Henrique Duarte et al.
Introduction: The efficacy of tamoxifen in breast cancer endocrine therapy may be compromised by factors such as low adherence, drug interactions, and polymorphisms in CYP2D6, which is essential for converting tamoxifen i...
Effect of concomitant rifampin and clarithromycin on elexacaftor-tezacaftor-ivacaftor using a PBPK modeling approach [0.03%]
基于PBPK模型的联合使用利福平和克拉霉素对艾沙他韦/泰萨他韦/维卡他韦药代动力学影响研究
Madeline Sanders,Eunjin Hong,Manya Jain et al.
Madeline Sanders et al.
Background: Rifampin (RIF) is first-line therapy for Mycobacterium avium complex (MAC) in people with cystic fibrosis (CF); but it induces CYP3A, causing significant drug - drug interactions (DDIs) with elexacaftor/tezaca...
Gastrointestinal bleeding risk among antithrombotics users: a propensity score matched study of drug classes [0.03%]
抗凝药使用者的胃肠出血风险：药物种类的倾向得分匹配研究
Prajwal M Pradhan,Erich Kummerfeld,Steven Johnson et al.
Prajwal M Pradhan et al.
Background: Antithrombotic drug-drug interactions (DDIs) impact patient safety. This study used causal inference framework to examine the association between interacting drugs, direct oral anticoagulants (DOACs), antiplat...