SARS-CoV-2 vaccination and plasma levels of psychotropic agents: a prospective cohort study [0.03%]
关于新冠病毒疫苗与心境稳定剂血药浓度：一项前瞻性队列研究
Stefano Ferrea,Nazar Kuzo,Giancarlo Giupponi et al.
Stefano Ferrea et al.
Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections induce immunological and inflammatory reactions that may have an impact on cytochrome P450 activity, altering the metabolism of psychotro...
Pharmacokinetics of apixaban in patients with short bowel syndrome: a Bayesian re-estimation approach [0.03%]
贝叶斯重新估计法在短肠综合征患者阿哌沙班药代动力学中的应用
Karolína Hronová,Irena Štenglová Netíková,Eva Meisnerová et al.
Karolína Hronová et al.
Background: Short bowel syndrome (SBS) is a malabsorptive condition that may impair drug absorption, including direct oral anticoagulants such as apixaban. This study aimed to assess whether the pharmacokinetics (PK) of a...
Pharmacokinetic drug evaluation of co-packaged sulbactam for injection and durlobactam for injection for the treatment of Acinetobacter baumannii-calcoaceticus complex in HABP/VABP [0.03%]
用于治疗碳青霉烯类耐药产金属酶鲍曼不动杆菌医院获得性肺炎/呼吸机相关性肺炎的注射用他利霉素与注射用舒巴坦组合包装药物评价的药代动力学研究
Rodrigo M Burgos,Yifan Wang,Jysheng Hou et al.
Rodrigo M Burgos et al.
Introduction: Carbapenem-resistant Acinetobacter baumannii (CRAB) is an urgent-priority pathogen that is associated with high mortality and leaves clinicians reliant on nephrotoxic salvage regimens. Sulbactam/durlobactam ...
The misleading accuracy of propofol PK/PD models: why hypoalbuminemia matters [0.03%]
丙泊酚药代动力学/药效学模型的误导性准确性：低白蛋白血症的影响不容忽视
Manon Launay,Peggy Gandia,Aline Albi-Feldzer et al.
Manon Launay et al.
Pharmacokinetics and safety of the combination of KL130008 and methotrexate in rheumatoid arthritis patients: a multicenter, open-label phase Ib trial [0.03%]
KL130008联合甲氨蝶呤在类风湿关节炎患者中的药代动力学和安全性：一项多中心开放标签Ⅰb期临床试验
Yue Cheng,Man Chen,Jing Yu et al.
Yue Cheng et al.
Background: The combination of the JAK1/2 inhibitor KL130008 with methotrexate (MTX) is expected to improve treatment outcomes in rheumatoid arthritis (RA). This study evaluated the pharmacokinetics and safety of this com...
Exploring drug interactions between newer antidepressants and medications used to treat neurological disorders [0.03%]
探究新型抗抑郁药与治疗神经障碍药物之间相互作用的现象
Marika Alborghetti,Maria Antonietta Barbieri,Ferdinando Nicoletti et al.
Marika Alborghetti et al.
Introduction: This review examines clinically relevant drug interactions (DIs) between newer antidepressants and medications used to manage neurological disorders frequently comorbid with depression, including Parkinson's...
Safety, pharmacokinetics, and bioequivalence of vunakizumab injection, a specific dermatitis drug, in healthy Chinese volunteers: an open-label, randomized, two-stage, two-sequence cross-over study [0.03%]
用于健康受试者的特应性皮炎药物注射用伍纳珠单抗的安全性、药代动力学及生物等效性：一项开放标签、随机、两阶段、两周期交叉试验
Yalu Dong,Xuehu Gao,Sheng Feng et al.
Yalu Dong et al.
Objectives: Vunakizumab (SHR-1314) is a novel IL-17A monoclonal antibody that has demonstrated great efficacy and safety in treating moderate-to-severe plaque psoriasis. This study aimed to evaluate the pharmacokinetics a...
Paternal exposure to antiseizure medications and offspring outcomes: a systematic review and meta-analysis of observational studies [0.03%]
男性抗癫痫药物暴露与后代结局：观察性研究的系统评价和meta分析
Vivia Ochmann,Christos Gkoltsos,Chiara Gastaldon et al.
Vivia Ochmann et al.
Introduction: To assess the risk of adverse offspring outcomes related to paternal antiseizure treatment during conception. Methods: We...
Language models for drug-drug interactions: current applications, pitfalls, and future directions [0.03%]
药物相互作用的语言模型：当前应用、陷阱和未来方向
Ahmad Z Al Meslamani,Abdallah Abou Hajal
Ahmad Z Al Meslamani
Introduction: Advanced artificial intelligence (AI) frameworks particularly, large language models (LLMs) have recently attracted attention for automating Drug - drug interactions (DDIs) extraction and prediction tasks. H...
Psychedelics, psychiatry and pharmacokinetics - where are we now? [0.03%]
psychedelics、精神病学和药代动力学- 我们现在处于什么位置？
Alice Caulfield,Elliot Hampsey,Allan H Young
Alice Caulfield