Nanomedicine-based TRPV1 targeting for osteoarthritis therapy: promise and pitfalls [0.03%]
基于纳米药物的TRPV1靶向治疗骨关节炎：前景与挑战
Qing Yao,Yifan Qiu,Haoxiong Guan et al.
Qing Yao et al.
João Paulo Figueiró Longo,Josué de Moraes
João Paulo Figueiró Longo
Introduction: Recent advances in nanoformulations are reshaping the treatment landscape for helminthiasis by addressing critical challenges such as drug resistance, poor bioavailability, and off-target effects. ...
Bharath Raj Madhanagopal,Arun Richard Chandrasekaran
Bharath Raj Madhanagopal
Lipid carrier-based intranasal delivery of calcium channel blockers for Alzheimer's disease [0.03%]
基于脂质载体的钙通道阻滞剂鼻内给药治疗阿尔茨海默病
Sunil Jog,Sayali Dighe,Khushali Nathani et al.
Sunil Jog et al.
Background: Felodipine (FLD) is a L-type calcium channel blocker with pronounced neuroprotection against Alzheimer's disease (AD). Unfortunately, the efficacy of FLD has been impeded by limited solubility, poor bioavailab...
Comparison of the pharmacokinetics of MR-107A-02, a novel fast-absorbing formulation of meloxicam, versus standard meloxicam reference: a phase I study [0.03%]
一项I期临床研究：新型盐酸美洛昔康速释片（MR-107A-02）与参比制剂的药代动力学比较研究
Matthew A Hummel,Andrew Shaw,Mark Shiyao Liu et al.
Matthew A Hummel et al.
Background: MR-107A-02 is a novel faster dissolving oral formulation of meloxicam to provide rapid absorption and faster onset of action in acute pain settings. This study compared the single-dose pharmacokinetics of MR-1...
From stem cell transplantation to stem cell-based drug delivery systems targeting hematological malignancies: recent advances and clinical considerations [0.03%]
从干细胞移植到针对血液系统恶性肿瘤的基于干细胞的药物递送系统：近期进展与临床考量
Ping Zhang,Ruyi Lin,Jianqing Gao et al.
Ping Zhang et al.
Introduction: Hematopoietic stem cell transplantation (HSCT) is a promising treatment option for hematological malignancies. Despite its curative potential, it faces clinical challenges, including relapse and graft-versus...
Explicit analysis of in vivo, meterological and statistical hurdles in successful clinical translation of targeted nanomedicines and plausible remedial strategies [0.03%]
针对靶向纳米药物临床转化的体内、气象及统计学障碍的实证分析与可能的补救策略
Saba Khan,Azka Gull,Masheera Akhtar et al.
Saba Khan et al.
Introduction: The potential of nanomedicine in alleviating different disorders is immense, but its clinical translation rate is severely debilitated, despite promising preclinical study outcomes. For therapeutically succe...
Metallic and lipid nanoparticles against multidrug resistant candida: advances and translational hurdles [0.03%]
抗多重耐药白色念珠菌的金属和脂质纳米粒子：进展与转化障碍
Manoj Dalabehera,Rudra Narayan Subudhi,Joshua Boateng et al.
Manoj Dalabehera et al.
Introduction: Among the many ongoing difficulties, Candida infections present significant clinical hurdles due to the rapid development of resistance, recurrent episodes, and the limited effectiveness of conventional ther...
Mayesha B Mustafa,Jinchao Lou,Michael D Best
Mayesha B Mustafa
Introduction: Elevated levels of reactive oxygen species (ROS), which are key mediators in different pathophysiological conditions, provide a unique opportunity for achieving targeted drug delivery. As such, ROS-responsiv...
Clinical insights into extracellular vesicles for targeted myocardial drug delivery [0.03%]
外泌体靶向心肌药物输送的临床见解
Haoran Wang,Guoyue Wei,Jie Yin et al.
Haoran Wang et al.
Introduction: The heart is a highly dynamic organ with limited regenerative capacity and a unique microvascular environment, which restricts the accumulation and retention of systemically administered therapeutics. Despit...