Targeting the brain: alternative administration routes and drug delivery systems for antidepressant therapy [0.03%]
Inês Figueiredo,Joana Bicker,Carla Vitorino et al.
Inês Figueiredo et al.
Introduction: Although numerous antidepressants are clinically available, they are characterized by slow therapeutic onset, systemic effects, and limited brain exposure, which is restricted by the blood-brain barrier (BBB...
Advancing transdermal drug delivery: integration of microneedle technology and iontophoresis for enhanced therapeutic outcomes [0.03%]
Meheli Ghosh,Amruta A Dandekar,Ajay K Banga et al.
Meheli Ghosh et al.
Introduction: Integrated microneedle-iontophoresis (MN-ITP) systems are emerging as a promising approach to improve transdermal drug delivery. These work by dual effect, such as mechanical disruption of the stratum corneu...
Soft‑mist inhaler spray dynamics and laryngeal deposition in upper airway models [0.03%]
软雾吸入剂喷射动力学及上呼吸道模型声门沉积分布研究
Brenda Vara Almirall,Chun Yuen Jerry Wong,Hua Qian Ang et al.
Brenda Vara Almirall et al.
Background: Targeted laryngeal drug delivery is clinically valuable for procedures requiring rapid topical anesthesia. This study evaluated how the mist from a soft-mist inhaler (Softbreezer) interacts with realistic uppe...
Penetration enhancer-containing vesicles (PEVs): from deformable liposomes to barrier-modulating delivery platforms across multiple administration routes [0.03%]
渗透增强型囊泡(PEV)：从可变形脂质体到多种给药途径下的屏障调节递送平台
Ines Castangia,Maria Manconi,Bianca Maria Baroli et al.
Ines Castangia et al.
Introduction: Penetration enhancer-containing vesicles (PEVs) were developed as lipid-based nanocarriers integrating vesicle deformability with controlled modulation of barrier architecture to improve drug permeation and ...
Progress and challenges in drug delivery for the treatment of Alzheimer's disease [0.03%]
阿尔茨海默病治疗中的给药进展与挑战
Farid Hajareh Haghighi,Jin Xie,Eric T Ebert et al.
Farid Hajareh Haghighi et al.
Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder marked by declining memory and cognitive function. Despite recent advances to slowdown early-stage progression, no curative therapies exist due to cha...
G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology [0.03%]
G-四链体作为抗癌药物递送的治疗平台：从固有的细胞毒性到药物传递及纳米技术
Arnau Domínguez,Natalia Navarro,Anna Aviñó et al.
Arnau Domínguez et al.
Introduction: G-quadruplexes have emerged as a versatile class of oligonucleotides that combine molecular recognition, intrinsic anticancer activity and drug carrier functions, offering new opportunities to improve tumor ...
Review of the first on-body injector (OBI) for the subcutaneous delivery of an oncology drug: isatuximab in multiple myeloma [0.03%]
首个皮下给药抗癌药物的体内注射器(OBI)的回顾：多发性骨髓瘤中的Isatuximab
Enrique M Ocio,Gurdeep Parmar,María-Victoria Mateos et al.
Enrique M Ocio et al.
Introduction: The landscape of drug-delivery methods in oncology is evolving, with increased availability of subcutaneous (SC) drug administration options. SC injections reduce treatment duration and enhance patient comfo...
Where do we stand now regarding protein nanoparticles? Perspectives from the Six Thinking Hats framework [0.03%]
六顶思考帽框架下的蛋白质纳米颗粒的发展及展望
Mengqin Guo,Chuanbin Wu,Xin Pan et al.
Mengqin Guo et al.
Introduction: This review highlights the critical role of protein nanoparticles (PNPs) in advancing precision therapy and introduces Edward de Bono's Six Thinking Hats (STH) framework as an innovative, structured paradigm...
Biomimetic nanocarriers as advanced drug delivery strategies in neurological disorders [0.03%]
模拟天然细胞的纳米载体作为神经性疾病药物递送的高级策略
Neha Ghosh,Shivam Pathak,Rupam Bera et al.
Neha Ghosh et al.
Introduction: Neurological disorders represent a major and growing global health challenge due to complex central nervous system pathology and limited drug penetration across the blood-brain barrier. Conventional therapie...
Niels Christian Nilsson,Horacio Pace-Bedetti,Lone Hallum et al.
Niels Christian Nilsson et al.
Background: Shield-activated autoinjectors are common for self-administration of medication, but data describing the strength required for their operation remain scarce. This study quantifies the maximum force capabilitie...