Advances in mucoadhesive and mucus-penetrating materials, nano-formulations, and in situ gelling systems for nasal drug delivery [0.03%]
用于鼻部给药的黏膜粘附和穿透黏液材料、纳米递送系统及原位凝胶系统的进展
Natalia N Porfiryeva,Rouslan I Moustafine,Vitaliy V Khutoryanskiy
Natalia N Porfiryeva
Introduction: Intranasal drug delivery is increasingly valued not only for local therapy but also as a noninvasive route that can bypass the blood - brain barrier, enabling rapid treatment of neurological and systemic dis...
Chitosan nanoparticles for brain targeted nose-to-brain drug delivery in neurodegenerative disease: a comprehensive exploration of advances, limitations and future prospects [0.03%]
壳聚糖纳米颗粒在神经退行性疾病鼻用脑定位递药中的应用：进展、局限及未来展望的全面探究
Mumtaz,Devika Unnithan,Hadiseh Hosseini et al.
Mumtaz et al.
awrhWR4JHerhERHaerh. Keywords: Neurodegenerative diseases; blood-brain barrier; chitosan nanoparticles; drug...
Redox responsive cyclodextrin-based drug delivery systems: a special insight to glutathione responsive CD-nanosponges [0.03%]
基于环糊精的药物递送系统：谷胱甘肽响应性CD-纳米海绵的特殊见解
Sanaz Mohammadvalipour,Ziba Islambulchilar,Hadi Valizadeh et al.
Sanaz Mohammadvalipour et al.
Introduction: Advances in nanotechnology and nanomedicine increasingly focus on the rational design of smart nanocarriers capable of site-specific and stimulus-triggered drug release to improve therapeutic efficacy and re...
User acceptability and ease of use of the MedRing, a new personalized vaginal drug delivery and monitoring device [0.03%]
一种新型个性化阴道药物输送和监测装置MedRing的用户接受性和易用性研究
Joggem Veen,Marian Engberts,Maarten Wiegerinck et al.
Joggem Veen et al.
Background: The MedRing is an innovative, flexible vaginal ring that, unlike other rings, allows personalized drug administration and monitoring. This study evaluated its user acceptability and ease of use. ...
Therapeutic nanofibrous scaffolds in precision drug delivery: formulation design, challenges and regulatory frameworks [0.03%]
精准药物输送的治疗纳米纤维支架：设计、挑战及监管框架
Mariam Majida Shokoya,Edina Szabó,Zsombor Kristóf Nagy et al.
Mariam Majida Shokoya et al.
Introduction: Drug-loaded nanofibrous systems represent a breakthrough in drug delivery, overcoming limitations of conventional formulations. They demonstrate controlled morphology and flexibility across multiple administ...
Clinical hurdles for curcumin and piperine nanoparticles in prostate cancer treatment: a bridge too far or a path to clinical reality? [0.03%]
纳米粒状姜黄素和胡椒碱在前列腺癌治疗中的临床障碍：难以逾越的鸿沟还是通向临床现实的道路？
Jibira Yakubu,Oya Tagit,Amit V Pandey
Jibira Yakubu
Introduction: Prostate cancer (PC) treatment is limited by resistance mechanisms and cumulative toxicities, necessitating novel therapeutic strategies. While curcumin and piperine exhibit potent anticancer properties, the...
Application of iron oxide nanoparticles in liver drug delivery: insights into biodegradation and toxicity at cellular, tissue, and organ levels [0.03%]
铁氧化物纳米颗粒在肝脏药物递送中的应用：细胞、组织和器官水平上的生物降解和毒性的新见解
Anna F Sheptulina,Ekaterina O Moiseeva,Sergei V German et al.
Anna F Sheptulina et al.
Introduction: Due to its unique anatomical and physiological properties, the liver is known to capture the prevailing amount of intravenously administered nanoparticles. However, selectively delivering them to hepatocytes...
A comprehensive review of the Maillard reaction in solid pharmaceutical dosage forms: a focus on lactose [0.03%]
乳糖固体制剂美拉德反应的研究进展及影响因素探讨
Jia Xiang,Shipeng Chen,Songwen Tan
Jia Xiang
Introduction: Solid dosage forms face the risk of the Maillard reaction during development and storage. This reaction occurs between reducing excipients and amino-group-containing drugs, potentially leading to discolorati...
Katharina S Berryman,Maria Gracia Mora Pinos,Amy Skarsfeldt et al.
Katharina S Berryman et al.
Introduction: Deferoxamine (DFO) is an iron-chelator, approved for systemic treatment of iron overload. New research finds local applications to mechanistically correct ischemia-driven hypoxia that underlies chronic wound...
Ye Cao,Yee Shan Wong,Subbu S Venkatraman
Ye Cao
Introduction: The ideal Drug delivery systems (DDS) should be able to effectively and efficiently deliver the drugs to the targeted tissue or cells, releasing them at a desired rate while retaining their bioactivity. Howe...