Particle morphology: an important factor affecting drug delivery by nanocarriers into solid tumors [0.03%]
颗粒形态：影响纳米载体递送药物进入实体瘤的重要因素
Zhen Wang,Zimei Wu,Jianping Liu et al.
Zhen Wang et al.
Introduction: Efficient delivery of drugs by nanoparticles deep into solid tumors is the precondition of valid cancer therapy. Despite profound understanding of the delivery of spherical nanoparticles into solid tumor att...
Nanomedicine for immunosuppressive therapy: achievements in pre-clinical and clinical research [0.03%]
免疫抑制治疗纳米药物学：前期研究与临床试验的成果总结
Hanan Al-Lawati,Hamidreza Montazeri Aliabadi,Behzad Sharif Makhmalzadeh et al.
Hanan Al-Lawati et al.
Introduction: Immunosuppression is the mainstay therapy in organ transplantation and autoimmune diseases. The effective clinical application of immunosuppressive agents has suffered from the emergence of systemic immunosu...
Development and characterization of lipid-polymeric nanoparticles for oral insulin delivery [0.03%]
口服胰岛素递送的脂质-聚合物纳米粒子的开发与表征
Débora Sgorla,Anna Lechanteur,Andreia Almeida et al.
Débora Sgorla et al.
The oral route is widely accepted as the most physiological path for exogenous administration of insulin, as it closely mimic the endogenous insulin pathway. Thus, in this work it is proposed an innovative lipid-polymeric nanocarrier to del...
Equivalence of glatiramer acetate products: challenges in assessing pharmaceutical equivalence and critical clinical performance attributes [0.03%]
醋酸格拉替雷产品的等效性：评估药物等效性和关键临床性能属性的挑战
G Borchard,D J A Crommelin
G Borchard
Introduction: This review discusses the challenges to characterize and evaluate the peptide based drug glatiramer acetate (GA) and its follow-on products used for treatment of multiple sclerosis patients. ...
Pen devices for self-injection: contrasting measured injection force with users' perceived ease of injection [0.03%]
笔式注射装置：对比测量推注力与用户使用感受
Andreas E Schneider,Jakob Lange
Andreas E Schneider
Objectives: Past research has emphasized injection force as a clinically highly relevant technical attribute of pen devices. However, little work has been conducted to relate these results to in-use studies. This article ...
Comparative Study
Expert opinion on drug delivery. 2018 Feb;15(2):115-125. DOI:10.1080/17425247.2018.1415884 2018
Ease of use of two autoinjectors in patients with multiple sclerosis treated with interferon beta-1a subcutaneously three times weekly: results of the randomized, crossover REDEFINE study [0.03%]
关于干扰素β-1A皮下注射治疗的多发性硬化症患者使用两种自动注射器的便利性的随机交叉研究结果：重新定义研究
Sibyl Wray,Brooke Hayward,Fernando Dangond et al.
Sibyl Wray et al.
Background: For interferon beta-1a subcutaneously three times weekly (IFN β-1a SC tiw), administration options include manually injected prefilled syringes; a preassembled, single-use autoinjector; and a reusable autoinj...
US human factors engineering evaluation of an updated follitropin alfa pen injector (GONAL-f® RFF Redi-ject®) and instructions for use [0.03%]
美国人的因素工程学评估：一种更新后的重组人促卵泡激素笔式注射剂（力 Rewrite: 重组人生长激素预装注射器的人因工程学评估与使用说明书调查研究
Mary Mahony,Andrea Dwyer,Raschelle Barkume et al.
Mary Mahony et al.
Objectives: The multi-dose, pre-filled GONAL-f® RFF Redi-ject® (follitropin alfa injection) pen injector was updated following feedback on user experience and pen functionality, as part of a continuous assessment progra...
Human studies with microneedles for evaluation of their efficacy and safety [0.03%]
微针的人体研究以评估其功效和安全性
Thuy Trang Nguyen,Jung Hwan Park
Thuy Trang Nguyen
Introduction: During the past two decades, many studies have documented the development of microneedles (MNs) as a feasible technique for the effective administration of drugs. More and more human studies have been done w...
S Kevin Li,Jinsong Hao
S Kevin Li
Introduction: The sclera is considered the 'static barrier,' a main barrier for transscleral drug delivery. The characterization of passive and iontophoretic transport across the sclera in vitro is the first step toward o...
Airway geometry, airway flow, and particle measurement methods: implications on pulmonary drug delivery [0.03%]
呼吸道解剖结构、气流及颗粒物检测方法对肺部给药的影响
A Kourmatzis,S Cheng,H-K Chan
A Kourmatzis
Introduction: The effectiveness of drug delivery to the lungs is inextricably linked to the fundamental interactions that occur between particles and flow in the extrathoracic airway. Research in this field requires time ...