Can insulin-fusion proteins overcome the current barriers in drug delivery to the brain? [0.03%]
胰岛素融合蛋白能克服当前的药物向脑部递送障碍吗？
Noriyasu Kamei
Noriyasu Kamei
Ruifang Yu,Lu Chen,Xiang Zhang et al.
Ruifang Yu et al.
Background: In the present study, we fabricated a multifunctional hydrogel nanocomposite for wound healing applications. Research design and methods: ...
The potential of a high efficacy single shot injection of artemisinin combination for effective antimalarial therapy [0.03%]
高效单一剂量青蒿素联合疗法的潜力可有效治疗疟疾
Padma V Devarajan,Maharukh T Rustomjee
Padma V Devarajan
Solvent-exchange-based in situ forming implants: advances and challenges as long-lasting formulations [0.03%]
基于溶剂交换的原位形成植入物：长效制剂的发展与挑战
Irene Lozza,Ana Isabel Fraguas-Sánchez,Cristina Martín-Sabroso et al.
Irene Lozza et al.
Introduction: In situ forming implants (ISFIs) are long-acting drug delivery systems that solidify at the injection site, creating a depot for sustained drug release from days to months. Compared with preformed implants, ...
Muhammad Aamir Hassan,Maged Abdelaziz,Sadaf Noor et al.
Muhammad Aamir Hassan et al.
Dual-phase exenatide delivery system: PLGA nanoparticles embedded in thermosensitive PLGA-PEG-PLGA hydrogel for sustained glycemic control [0.03%]
双相艾塞那肽输送系统：载有PLGA纳米粒的热敏PLGA-PEG-PLGA水凝胶用于持续血糖控制
Shu Pan,Nan Dong,Haoyang Yuan et al.
Shu Pan et al.
Background: Glucagon-like peptide-1 (GLP-1) receptor agonists have demonstrated significant clinical efficacy in recent years for the treatment of type 2 diabetes mellitus (T2DM) and obesity. However, their widespread app...
Nanomedicine-based TRPV1 targeting for osteoarthritis therapy: promise and pitfalls [0.03%]
基于纳米药物的TRPV1靶向治疗骨关节炎：前景与挑战
Qing Yao,Yifan Qiu,Haoxiong Guan et al.
Qing Yao et al.
João Paulo Figueiró Longo,Josué de Moraes
João Paulo Figueiró Longo
Introduction: Recent advances in nanoformulations are reshaping the treatment landscape for helminthiasis by addressing critical challenges such as drug resistance, poor bioavailability, and off-target effects. ...
Bharath Raj Madhanagopal,Arun Richard Chandrasekaran
Bharath Raj Madhanagopal
Lipid carrier-based intranasal delivery of calcium channel blockers for Alzheimer's disease [0.03%]
基于脂质载体的钙通道阻滞剂鼻内给药治疗阿尔茨海默病
Sunil Jog,Sayali Dighe,Khushali Nathani et al.
Sunil Jog et al.
Background: Felodipine (FLD) is a L-type calcium channel blocker with pronounced neuroprotection against Alzheimer's disease (AD). Unfortunately, the efficacy of FLD has been impeded by limited solubility, poor bioavailab...