Establishing national reference materials for genetic testing of cytochrome P450 [0.03%]
建立细胞色素P450基因检测的国家标准物质
Zheng Jia,Junju Huang,Ying Yang et al.
Zheng Jia et al.
Objectives: Reference materials for in-vitro diagnostic reagents play a critical role in determining the quality of reagents and ensuring the accuracy of clinical test results. This study aimed to establish a national ref...
Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis [0.03%]
揭穿遗传联系：HLA-B*15:02与抗癫痫药物引起的斯蒂文斯-约翰逊综合征/中毒性表皮坏死松解症的伞式综述
Kar Mun Tham,Jacklyn Jia Lin Yek,Christopher Wei Yang Liu
Kar Mun Tham
Purpose: This umbrella review was conducted to summarize the association between HLA*1502 allele with antiepileptic induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). ...
Effect of CYP2D6 genetic variation on patient-reported symptom improvement and side effects among children and adolescents treated with amphetamines [0.03%]
CYP2D6基因多态性对接受刺激剂治疗的儿童及青少年患者报告的症状改善和不良反应的影响
Samuel Gerlach,Abdullah Al Maruf,Sarker M Shaheen et al.
Samuel Gerlach et al.
Objectives: Amphetamine-based medications are recommended as a first-line pharmacotherapy for the treatment of attention-deficit/hyperactivity disorder in children and adolescents. However, the efficacy and tolerability o...
Irene Ferrer Bolufer,Ximo Galiana Vallés,Silvia Izquierdo Álvarez et al.
Irene Ferrer Bolufer et al.
Consensus guidelines for genotype-guided fluoropyrimidine dosing based on variation in the dihydropyrimidine dehydrogenase (DPYD) gene before treatment have been firmly established. The prior pharmacogenetic report avoids the serious toxici...
Association between CYP2C9 and VKORC1 genetic polymorphisms and efficacy and safety of warfarin in Chinese patients [0.03%]
CYP2C9和VKORC1基因多态性与中国患者华法林疗效和安全性之间的关联
Suli Zhang,Mingzhe Zhao,Shilong Zhong et al.
Suli Zhang et al.
Objectives: Genetic variation has been a major contributor to interindividual variability of warfarin dosage requirement. The specific genetic factors contributing to warfarin bleeding complications are largely unknown, p...
Associations of ADH1B and ALDH2 genotypes and alcohol flushing with drinking history, withdrawal symptoms, and ICD-10 criteria in Japanese alcohol-dependent men [0.03%]
ADH1B和ALDH2基因型以及酒精引起的脸红与日本酒精依赖男性患者的饮酒史，戒断症状及ICD-10标准的相关性研究
Akira Yokoyama,Tetsuji Yokoyama,Yosuke Yumoto et al.
Akira Yokoyama et al.
Objectives: Given the high prevalence of fast-metabolizing alcohol dehydrogenase-1B*2 (ADH1B*2 ) and inactive aldehyde dehydrogenase-2*2 (ALDH2*2 ) alleles in East Asians, we evaluated how the ADH1B / ALDH2 genotypes and ...
Zahi Nakad,Yolande Saab
Zahi Nakad
Objective: We aim to develop a personalized dosing tool for tricyclic antidepressants (TCAs) that integrates CYP2D6 and CYP2C19 gene variants and their effects while also considering the polypharmacy effect. ...
Pharmacogenetic considerations in therapy with novel antiplatelet and anticoagulant agents [0.03%]
新型抗血小板和抗凝剂治疗中的药理遗传学考虑因素
Anthony Yazbeck,Reem Akika,Zainab Awada et al.
Anthony Yazbeck et al.
Antiplatelets and anticoagulants are extensively used in cardiovascular medicine for the prevention and treatment of thrombosis in the venous and arterial circulations. Wide inter-individual variability has been observed in response to anti...
Prevalence of CYP2D6 structural variation in large retrospective study [0.03%]
大规模回顾研究中CYP2D6结构变异的普遍性
Samantha Frear,Ashley Sherman,Don Rule et al.
Samantha Frear et al.
CYP2D6 is a highly polymorphic gene with clinically important structural variations. Commonly, only exon 9 is assayed on clinical pharmacogenomics panels, as it allows for accurate functional characterization even in the presence of a CYP2D...
Pharmacogenomic allele coverage of genome-wide genotyping arrays: a comparative analysis [0.03%]
基因组范围的基因分型阵列中的药物基因组学等位基因覆盖范围：对比分析
Courtney Lenz,Ankita Narang,Chad A Bousman
Courtney Lenz
The use of genome-wide genotyping arrays in pharmacogenomics (PGx) research and clinical implementation applications is increasing but it is unclear which arrays are best suited for these applications. Here, we conduct a comparative coverag...
Comparative Study
Pharmacogenetics and genomics. 2024 Jun 1;34(4):130-134. DOI:10.1097/FPC.0000000000000523 2024