Prenatal efavirenz exposure is independently associated with maternal, but not fetal CYP2B6 genotype [0.03%]
孕前暴露于依非韦伦与母体和胎儿细胞色素P450 2B6基因型的独立关系无关
Oluwasegun Eniayewu,Abdulafeez Akinloye,Babajide Shenkoya et al.
Oluwasegun Eniayewu et al.
Objectives: Understanding the influence of fetal and maternal genetics on prenatal drug exposure could potentially improve benefit-risk evaluation. In this study, we investigated the impact of two functional polymorphisms...
Healthcare provider and patient perspectives on the implementation of pharmacogenetic-guided treatment in routine clinical practice [0.03%]
医疗保健提供者和患者对在常规临床实践中实施药物基因组学指导治疗的观点
Gurveer Kaur,Chukwunonso K Nwabufo
Gurveer Kaur
Objective: This study aims to understand patient and healthcare provider perspectives on the integration and application of pharmacogenetics (PGx) testing in routine clinical practice. ...
Exploring CYP2D6 polymorphisms and angiotensin receptor blocker response in the Bai hypertensive population [0.03%]
探索白族高血压人群CYP2D6多态性与血管紧张素受体阻滞剂的反应关系
Canbiao Yang,Guoqiang Zhang,Chang Shu et al.
Canbiao Yang et al.
Objective: The CYP2D6 enzyme is crucial for the metabolism and disposition of a variety of drugs. This study was conducted to examine the relationship between CYP2D6 gene polymorphisms and the response to angiotensin rece...
Differential expression of NAT1 pharmacogene in hormone receptor positive vs. negative female breast tumors may affect drug treatment [0.03%]
激素受体阳性与阴性女性乳腺肿瘤中NAT1基因的差异表达可能会影响药物治疗效果
Desislava Ivanova,Giannoulis Fakis,Sotiria Boukouvala
Desislava Ivanova
Studies have reported overexpression of NAT1 gene for xenobiotic metabolizing arylamine N-acetyltransferase type 1 in estrogen receptor positive breast tumors, and this association has been linked to patient chemoresistance and response to ...
Wei Mao,Tao Zhou,Feng Zhang et al.
Wei Mao et al.
Objective: Varied expression of drug-metabolizing enzymes (DME) genes dictates the intensity and duration of drug response in cancer treatment. This study aimed to investigate the transcriptional profile of DMEs in tumor ...
Interaction of age and CYP2C19 genotypes on voriconazole steady-state trough concentration in Chinese patients [0.03%]
年龄和CYP2C19基因型对中国患者伏立康唑谷浓度的影响
Yin-Xiao Du,Ying-Xia Zhu,Liang Li et al.
Yin-Xiao Du et al.
Objectives: Both age and CYP2C19 genotypes affect voriconazole plasma concentration; the interaction of age and CYP2C19 genotypes on voriconazole plasma concentration remains unknown. This study aims to investigate the co...
MEG3 in hematologic malignancies: from the role of disease biomarker to therapeutic target [0.03%]
MEG3在血液系统恶性肿瘤中的作用：从疾病生物标志物到治疗靶点
Chunlan Zhang,Yun Qin,Yun Tang et al.
Chunlan Zhang et al.
Maternally expressed gene 3 ( MEG3 ) is a noncoding RNA that is known as a tumor suppressor in solid cancers. Recently, a line of studies has emphasized its potential role in hematological malignancies in terms of tumorigenesis, metastasis,...
Effects of CYP3A5*3 genetic polymorphisms on the pharmacokinetics of perampanel in Chinese pediatric patients with epilepsy [0.03%]
CYP3A5*3基因多态性对中国儿童癫痫患者卫克帕内酯药动学的影响
Ting Zhao,Ji-Rong Feng,Hui-Lan Zhang et al.
Ting Zhao et al.
Purpose: This study was the first to evaluate the effect of CYP3A5*3 gene polymorphisms on plasma concentration of perampanel (PER) in Chinese pediatric patients with epilepsy. ...
Novel variant in Nudix hydrolase 15 gene influences 6-mercaptopurine toxicity in childhood acute lymphoblastic leukemia patients [0.03%]
儿童急性淋巴细胞白血病患者Nudix水解酶15基因新变异影响6硫代鸟嘌呤毒性作用
Zarina Sabirova,Shazia Mahnoor,Dina Lasfar et al.
Zarina Sabirova et al.
Acute lymphoblastic leukemia (ALL) is the most frequent pediatric cancer. 6-Mercaptopurine (6-MP) is a key component of ALL treatment. Its use, however, is also associated with adverse drug reactions, particularly myelosuppression. Thiopuri...
Predicted deleterious variants in ABCA1, LPL, LPA and KIF6 are associated with statin response and adverse events in patients with familial hypercholesterolemia and disturb protein structure and stability [0.03%]
ABCA1、LPL、LPA和KIF6的预测有害变异与家族性高胆固醇血症患者他汀类药物反应及不良事件相关并干扰蛋白质结构及稳定性
Carolina Dagli-Hernandez,Glaucio Monteiro Ferreira,Renata Caroline Costa de Freitas et al.
Carolina Dagli-Hernandez et al.
Objectives: This study explored the association of deleterious variants in pharmacodynamics (PD) genes with statin response and adverse effects in patients with familial hypercholesterolemia (FH) and analyzed their potent...