Association of VKORC1 and CYP2C9 gene polymorphisms with warfarin dose requirements in a representative Iranian population with cardiac valve replacement surgery [0.03%]
维柯尔基因和细胞色素P450同工酶2C9基因多态性与伊朗心脏瓣膜置换手术患者华法林维持剂量需求的相关性研究
Omid Maleki,Javad Gharechahi
Omid Maleki
Background: Warfarin is a commonly used oral anticoagulant for managing thromboembolic events after cardiac valve surgery. However, its optimal dose varies between individuals, often requiring trial and error to determine...
Targeting cardiomyopathies associated with RASopathies: the role of mitogen-activated protein kinase inhibitors and therapeutic challenges [0.03%]
针对RASopathy相关心肌病的治疗：细胞外信号调节激酶抑制剂的作用及治疗挑战
Valentina Botia-Arciniegas,Natalia Jimenez-Cardozo,Juliana Lores
Valentina Botia-Arciniegas
RASopathies are rare genetic disorders caused by germline mutations in genes that regulate the RAS-mitogen-activated protein kinase (MAPK) pathway, a critical pathway involved in various cellular processes. Disruption of this pathway leads ...
Integrating pharmacogenetics in sport medicine: enhancing treatment precision and preventing unintentional doping violation [0.03%]
运动医学中药物基因组学的整合：提高治疗精度和预防无意违规使用兴奋剂
Guillaume Drevin,Marie Briet,Chadi Abbara
Guillaume Drevin
Pharmacogenetic association of CYP enzymes with therapeutic propofol doses during mechanical ventilation [0.03%]
细胞色素P450酶与机械通气期间异丙酚治疗剂量的药物基因组学关联研究
Chanel Hsiang,Faisal Shakeel,Nicholas Farina et al.
Chanel Hsiang et al.
Propofol is commonly used to sedate patients, but variations in how individuals metabolize the drug may affect dosing requirements. The objective of this study was to explore how genetic variations in CYP450 enzymes, particularly CYP2B6, in...
Feasibility of pharmacogenetic-guided selection of postoperative analgesics in gynecologic surgery patients: a prospective, randomized, pilot study [0.03%]
妇科手术患者术后镇痛的药物基因指导选择的可行性：一项前瞻性随机试点研究
Glenda Hoffecker,Lakeisha Mulugeta-Gordon,Victoria Wittner et al.
Glenda Hoffecker et al.
Objectives: Evaluate the feasibility of implementing a multigene pharmacogenetic (PGx) test and genotype-guided pharmacist recommendations into gynecologic perioperative workflows and fidelity to pharmacist genotype-guide...
Assessment of the potential impact of polymorphisms in the Foxp3 and CTLA-4 genes in immune balance and disease susceptibility of primary Sjögren's syndrome [0.03%]
评估Foxp3和CTLA-4基因多态性在原发性舍格伦综合征免疫平衡及易感性中的潜在影响
Min Feng,Fanxing Meng,Yanlin Wang et al.
Min Feng et al.
Background: Regulatory T (Treg) cell depletion-associated immune tolerance deficiency have been shown to play a key role in the pathogenesis of primary Sjögren's syndrome (pSS). Treg cells mainly express the transcriptio...
UGT1A1 polymorphisms and metabolic phenotypes in indigenous peoples from the Brazilian Amazon [0.03%]
巴西亚马逊地区的土著人群中的UGT1A1多态性和代谢表型
Jamila A Perini,Alessandra S Dias,Leonor Gusmão et al.
Jamila A Perini et al.
Objectives: To explore the distribution of clinically relevant UGT1A1 polymorphisms and inferred UGT1A1 phenotypes in two Indigenous groups (Paiter-Suruí and Yanomami) from reservation areas in the Brazilian Amazon. ...
Impact of switching antiplatelet therapy in acute coronary syndrome patients with different CYP2C19 phenotypes: insights from a single-center study [0.03%]
不同CYP2C19表型急性冠脉综合征患者抗血小板治疗转换的影响：一项单中心研究的启示
Nagendra Boopathy Senguttuvan,Muralidharan Thoddi Ramamurthy,Nithesh Kumar et al.
Nagendra Boopathy Senguttuvan et al.
Objective: Optimizing antiplatelet therapy is crucial in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary interventions (PCIs). This study aimed to assess the prevalence of CYP2C19 loss-of-func...
Updated analysis of the pharmacogenomics of pediatric bronchodilator response [0.03%]
儿科支气管扩张剂反应的药理基因组学更新分析
Jennifer Brailsford,Guillaume Labilloy,Nolan Menze et al.
Jennifer Brailsford et al.
This short communication serves as an update to previously published pilot study results on bronchodilator response (BDR) in children with asthma. We expanded our cohort from 54 to 165 pediatric patients seeking emergency department care fo...
The impact of genetic variations in FPGS, MTHFR, and ATIC on methotrexate response among pediatric patients with acute lymphoblastic leukemia [0.03%]
FPGS，MTHFR和ATIC基因变异对急性淋巴细胞白血病儿童患者甲氨蝶呤反应的影响
Shu-Mei Wang,Dan-Qi Zhao,Xiao-Yan Kong et al.
Shu-Mei Wang et al.
Objectives: Genetic polymorphisms in FPGS, MTHFR, and ATIC have emerged as important modulators of methotrexate (MTX) metabolism and toxicity. We investigated the distribution of FPGS rs10106, MTHFR rs1801131, and ATIC rs...