Vitamin D receptor regulate placental ABCB1 expression transcriptionally by recruiting coactivator SRC-1 [0.03%]
维生素D受体通过招募共激活因子SRC-1调控胎盘ABCB1转录表达
Shuran Shao,Yu Yan,Lixia Yang et al.
Shuran Shao et al.
Background: P-glycoprotein (P-gp), the most extensively studied ATP-binding cassette (ABC) transporter, is expressed in the apical membrane of syncytiotrophoblast cells and plays a crucial role in placental drug transport...
Prevalence of CYP2C19 phenotypes in patients undergoing a hiatal hernia repair [0.03%]
接受胃食管结合部疝修补术患者的CYP2C19表型流行率
Abdel-Rahman Naser,Keouna Pather,Erin M Mobley et al.
Abdel-Rahman Naser et al.
Objectives: Gastroesophageal reflux disease is primarily treated with proton pump inhibitors (PPIs), which are metabolized by cytochrome P450 2C19 (CYP2C19) in the liver. CYP2C19 polymorphisms affect PPI plasma levels, wi...
Impact of CYP3A5 genotype on tacrolimus pharmacokinetics and clinical outcomes in pediatric patients with Henoch-Schönlein purpura nephritis [0.03%]
CYP3A5基因型对肾炎性紫癜患儿他克莫司药代动力学及临床结局的影响
Huiying Li,Na Li,Xiaoling Tang et al.
Huiying Li et al.
Aim: This study aimed to evaluate the impact of CYP3A5 gene polymorphism on the pharmacokinetics, therapeutic efficacy, and safety of tacrolimus in pediatric patients with Henoch-Schönlein purpura nephritis (HSPN). ...
CFTR genotype-phenotype associations and clinical outcomes in pediatric cystic fibrosis [0.03%]
儿童囊性纤维化患者中CTFR基因型表型关联及临床结局分析
Luana da Silva Baptista Arpini,Fernanda Mayrink Gonçalves Liberato,Sabrina da Silva Santos et al.
Luana da Silva Baptista Arpini et al.
Objective: To investigate the association between CFTR genotypes and clinical and nutritional outcomes in children and adolescents with cystic fibrosis (CF) receiving care within the public health system of Espírito Sant...
TWSG1 variation identifies a ustekinumab-response phenotype in patients with inflammatory bowel disease [0.03%]
TWSG1变异识别出炎症性肠病患者中的乌斯替单抗应答表型
Mohammed Alkhalifa,Gio R Dela Cruz,Terry Ponich et al.
Mohammed Alkhalifa et al.
Objectives: A genome-wide association study identified that genetic variation in the twisted gastrulation protein homolog-1 gene (TWSG1 rs7242593) was linked to early clinical remission in ustekinumab-exposed patients in ...
Characteristics of initial pharmacogenetic testing and subsequent physician referral behavior in youth mental health [0.03%]
儿童精神健康初始药物基因检测及其后续医师转诊行为的特征分析
Naomi Lemboye,Madison Heintz,Abdullah Al Maruf et al.
Naomi Lemboye et al.
While prior studies have focused on the clinical utility of pharmacogenetic (PGx) testing, less is known about factors that influence physicians' continued use of PGx testing in routine practice. Using data from the PGx-SParK trial, we exam...
Effects of apolipoprotein E and solute carrier organic anion transporter family member 1B1 gene polymorphisms on statin efficacy and safety in dyslipidemic patients [0.03%]
载脂蛋白E和溶质载体有机阴离子转运蛋白家族成员1B1基因多态性对血脂异常患者他汀疗效及安全性的研究
Xiaohong Wu,Yumei Cai,Yonglong Su et al.
Xiaohong Wu et al.
Objective: To investigate the distribution of the apolipoprotein E (ApoE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) polymorphisms in dyslipidemia patients and their impact on statin efficacy...
The potential effect and pathway of valsartan: genome-wide and phenome-wide association study from UK Biobank data [0.03%]
缬沙坦潜在效应和作用途径的全基因组和全表型组关联研究：英国生物银行数据的分析
Shengyin Zeng,Yaxin Li,Yucong Zhang et al.
Shengyin Zeng et al.
Purpose: Valsartan, an angiotensin II receptor blocker, is widely used for hypertension and heart failure. While its cardiovascular benefits are established, its broader pharmacological effects remain incompletely charact...
Application of risk priority number of failure mode and effects analysis to drug-variant pairs for severe cutaneous adverse reactions in Korean and American populations [0.03%]
风险优先数法在韩国人群和美国人群中用于药物与剂型组合的严重皮肤不良反应的风险评估
Hyun Kyung Lee,Min Ju Kang,Hajung Kim et al.
Hyun Kyung Lee et al.
Objectives: Given the varying frequency and significance of genetic factors associated with severe cutaneous adverse reactions (SCARs) across different ethnicities, this study aimed to identify high-risk priority drug-var...
The role of uridine diphosphate glucuronosyltransferase 1A4 polymorphisms on posaconazole exposure [0.03%]
尿苷二磷酸葡萄糖醛酸转移酶1A4多态性对泊沙康唑暴露的影响
Katherine Zhao,Vy Lam,Gregory Eschenauer et al.
Katherine Zhao et al.
Posaconazole is used to treat and prevent invasive fungal infections. Posaconazole metabolism is mediated by the uridine 5'-diphopho-glucuronosyltransferase (UGT) 1A4 enzyme; prior studies have suggested UGT1A4*3 contributes to low posacona...