Proteins involved in more domain types tend to be more essential [0.03%]
参与的结构域类型更多的蛋白质往往更关键essential的意思是关键的，在这个背景下更适合用“关键”而不是“重要”或其他词汇。
Lu Chen,Yingjiao Cheng,Min Li et al.
Lu Chen et al.
Investigation of essential proteins is significantly valuable for understanding of cellular life, drug design and other practical purposes. In most of current studies, essential proteins are generally mined in protein-protein interaction (P...
This special issue includes a selection of papers presented at the 2nd IEEE International Conference. Introduction [0.03%]
本期专题节选了IEEE举行的第2次国际会议的几篇论文。导言
Ion Mandoiu,Mihai Pop,Sanguthevar Rajasekaran et al.
Ion Mandoiu et al.
Golnaz Taheri,Marzieh Ayati,Limsoon Wong et al.
Golnaz Taheri et al.
Removal of proteins on an essential pathway of a pathogen is expected to prohibit the pathogen from performing a vital function. To disrupt these pathways, we consider a cut set S of simple graph G, where G representing the PPI network of t...
Tahleen A Rahman,Dhruba K Bhattacharyya
Tahleen A Rahman
A number of clustering methods introduced for analysis of gene expression data for extracting potential relationships among the genes are studied and reported in this paper. An effective unsupervised method (TDAC) is proposed for simultaneo...
Identifying protein complexes based on the integration of PPI network and gene expression data [0.03%]
基于PPI网络和基因表达数据的蛋白质复合物识别方法
Weijie Chen,Min Li,Xuehong Wu et al.
Weijie Chen et al.
Identification of protein complexes is crucial to understand principles of cellular organisation and predict protein functions. In this paper, a novel protein complex discovery algorithm IPCIPG is proposed based on the integration of Protei...
RadixHap: a radix tree-based heuristic for solving the single individual haplotyping problem [0.03%]
基于径向树的单个体基因分型问题求解启发式算法 RadixHap
Tai-Chun Wang,Javid Taheri,Albert Y Zomaya
Tai-Chun Wang
Single nucleotide polymorphism studies have recently received significant amount of attention from researchers in many life science disciplines. Previous researches indicated that a series of SNPs from the same chromosome, called haplotype,...
To study percentage distribution of target genes encoding proteins of different classes in Helicobacter pylori strain J99 and identification of potential therapeutic targets to reduce its proliferation [0.03%]
幽门螺旋杆菌毒力基因表达的量化及其作为减少菌群增殖靶标的潜力研究
Megha Vaidya,Hetalkumar Panchal
Megha Vaidya
Helicobacter pylori are one of the most common bacterial pathogens in humans whose seropositivity increases with age and low socio-economic status. Due to presence of its pathogenic-island causes chronic persistent and atrophic gastritis in...
Introducing the hypothome: a way to integrate predicted proteins in interactomes [0.03%]
介绍hypothome：一种在相互作用组中整合预测蛋白的方法
Claus Desler,Sine Zambach,Prashanth Suravajhala et al.
Claus Desler et al.
An interactome is defined as a network of protein-protein interactions built from experimentally verified interactions. Basic science as well as application-based research of potential new drugs can be promoted by including proteins that ar...
Developing a novel test to detect cancer genes from microarray data [0.03%]
开发一种新颖的测试方法，从微阵列数据中检测癌症基因
Shreya Mathur,Sunil Mathur
Shreya Mathur
DNA microarray technology can simultaneously screen thousands of gene expression profiles, transforming how genetics is applied in medicine. However, the lack of normality in microarray data renders common statistical methods ineffective. W...
Drawing inferences from clinical studies with missing values using genetic algorithm [0.03%]
使用遗传算法从具有缺失值的临床研究中得出结论
R Devi Priya,S Kuppuswami
R Devi Priya
Missing data problem degrades the statistical power of any analysis made in clinical studies. To infer valid results from such studies, suitable method is required to replace the missing values. There is no method which can be universally a...