Ridge regression based hybrid genetic algorithms for multi-locus quantitative trait mapping [0.03%]
基于岭回归的混合遗传算法在多基因定位中的应用
Bin Zhang,Steve Horvath
Bin Zhang
Genetic algorithms (GAs) are increasingly used in large and complex optimisation problems. Here we use GAs to optimise fitness functions related to ridge regression, which is a classical statistical procedure for dealing with a large number...
Linear reduction method for predictive and informative tag SNP selection [0.03%]
线性降维的预测和甄选标签SNP方法研究
Jingwu He,Kelly Westbrooks,Alexander Zelikovsky
Jingwu He
Constructing a complete human haplotype map is helpful when associating complex diseases with their related SNPs. Unfortunately, the number of SNPs is very large and it is costly to sequence many individuals. Therefore, it is desirable to r...
Beeta Masoumi,Marcel Turcotte
Beeta Masoumi
Comparative RNA sequence analyses have contributed remarkably accurate predictions. The recent determination of the 30S and 50S ribosomal subunits bringing more supporting evidence. Several inference tools are combining free energy minimisa...
Dumitru Brinza,Jingwu He,Weidong Mao et al.
Dumitru Brinza et al.
Although there exist many phasing methods for unrelated adults or pedigrees, phasing and missing data recovery for data representing family trios is lagging behind. This paper is an attempt to fill this gap by considering the following prob...
Liang Chen,Sharmin Nilufar
Liang Chen
Following the theory on regional and national voting, we constructed a regional voting version NN from Pedersen-Nielsen's NN for start codon prediction in nucleotide sequences. Experiments on the TIS data of vertebrate and Arabidopsis thali...
Derek Ruths,Luay Nakhleh
Derek Ruths
The role of phylogeny in guiding comparative studies is rapidly growing in the post genomic era. Most phylogeny reconstruction methods though, assume a single tree underlying a given alignment of sequences. However, when events such as reco...
Effective statistical features for coding and non-coding DNA sequence classification for yeast, C. elegans and human [0.03%]
酵母、线虫和人类基因组中编码与非编码DNA序列分类的有效统计特征研究
Alan Wee-Chung Liew,Yonghui Wu,Hong Yan et al.
Alan Wee-Chung Liew et al.
This study performs a quantitative evaluation of the different coding features in terms of their information content for the classification of coding and non-coding regions for three species. Our study indicated that coding features that ar...
Logistic support vector machines and their application to gene expression data [0.03%]
逻辑支集向量机及其在基因表达数据中应用研究
Zhenqiu Liu,Dechang Chen,Ying Xu et al.
Zhenqiu Liu et al.
One important feature of the gene expression data is that the number of genes m far exceeds the number of samples n. When applied to analyse the gene expression data, standard statistical methods do not work well when n < m. Development of ...
Ding-Zhu Du,Frank K Hwang
Ding-Zhu Du
Farach et al. introduced the inhibitor model in pooling design, where existence of a single inhibitor clone in a pool dictates its outcome to be negative regardless of the existence of positive clones in the pool. Various sequential or mult...
Bhaskar Dasgupta,Kishori M Konwar,Ion I Mandoiu et al.
Bhaskar Dasgupta et al.
String barcoding is a recently introduced technique for genomic based identification of microorganisms. In this paper, we describe the engineering of highly scalable algorithms for robust string barcoding. Our methods enable distinguisher s...