Decoding algorithms in pooling designs with inhibitors and error-tolerance [0.03%]
含有抑制物的池检设计的可译性算法及容错性研究
My T Thai,David Maccallum,Ping Deng et al.
My T Thai et al.
Pooling designs are used in DNA library screening to efficiently distinguish positive from negative clones, which is fundamental for studying gene functions and many other biological applications. One challenge is to design decoding algorit...
Supervised classification of protein structures based on convex hull representation [0.03%]
基于凸包表示的蛋白质结构监督分类
Yong Wang,Ling-Yun Wu,Luonan Chen et al.
Yong Wang et al.
One of the central problems in functional genomics is to establish the classification schemes of protein structures. In this paper the relationship of protein structures is uncovered within the framework of supervised learning. Specifically...
Xiandong Meng,Vipin Chaudhary
Xiandong Meng
New biological experimental techniques are continuing to generate large amounts of data using DNA, RNA, human genome and protein sequences. The quantity and quality of data from these experiments makes analyses of their results very time-co...
Yiming Li
Yiming Li
The numerical solution of a master equation involves the calculation of eigenpairs for the corresponding transition matrix. In this paper, we computationally study the folding rate for a kinetics problem of protein folding by solving a larg...
PRec-I-DCM3: a parallel framework for fast and accurate large-scale phylogeny reconstruction [0.03%]
PRec-I-DCM3：一种用于快速和准确的大规模系统发育重建的并行框架
Yuri Dotsenko,Cristian Coarfa,Luay Nakhleh et al.
Yuri Dotsenko et al.
Accurate reconstruction of phylogenetic trees often involves solving hard optimisation problems, particularly the Maximum Parsimony (MP) and Maximum Likelihood (ML) problems. Various heuristics yield good results for these problems within r...
Tim Oliver,Bertil Schmidt,Douglas Maskell et al.
Tim Oliver et al.
Progressive alignment is a widely used approach to compute multiple sequence alignments (MSAs). However, aligning several hundred sequences by popular progressive alignment tools requires hours on sequential computers. Due to the rapid grow...
MESSM: a framework for protein fold recognition using neural networks and support vector machines [0.03%]
基于神经网络和支持向量机的蛋白质折叠识别框架(MESSM)
Nan Jiang,Wendy Wu,Ian Mitchell
Nan Jiang
A new framework (called MESSM) for protein fold recognition with three key features is proposed in this paper. Being tested on three benchmark problems, the results show that the MESSM has a comparable performance on fold recognition to tho...
Concurrent numerical simulation of flow and blood clotting using the lattice Boltzmann technique [0.03%]
基于格子玻尔兹曼方法的流场及血栓形成过程的耦合数值模拟研究
Jorg Bernsdorf,Sarah E Harrison,Stephen M Smith et al.
Jorg Bernsdorf et al.
In this paper, we describe a novel approach for a concurrent numerical simulation of the unsteady flow within an idealised stenosed artery and a simplified blood clotting process based on a residence time model. The applied numerical scheme...
Rotational and translational alignment errors in 3D reconstruction of virus structures at high resolution [0.03%]
高分辨率病毒结构三维重建中的旋转和平移对准误差
Yongchang Ji,Dan C Marinescu
Yongchang Ji
The 3D reconstruction of virus structures at high resolution using CryoTEM data requires a very accurate rotational and translational alignment of individual views obtained experimentally. We discuss the geometrical foundations and the comp...
A parallel implementation of 2-D/3-D image registration for computer-assisted surgery [0.03%]
计算机辅助手术中二维/三维图像配准的并行实现方法研究
Fumihiko Ino,Yasuhiro Kawasaki,Takahito Tashiro et al.
Fumihiko Ino et al.
Image registration is a technique usually used for aligning two different images taken at different times and/or from different viewing points. A key challenge for medical image registration is to minimise computation time with a small alig...