Hyrum D Carroll,Perry G Ridge,Mark J Clement et al.
Hyrum D Carroll et al.
Fundamental to Multiple Sequence Alignment (MSA) algorithms is modelling insertions and deletions (gaps). The most prevalent model is to use Gap Open Penalties (GOP) and Gap Extension Penalties (GEP). While GOP and GEP are well understood c...
Inferring protein-protein interaction networks from protein complex data [0.03%]
根据蛋白质复合物数据推理蛋白质相互作用网络
Shawn Martin,Zisu Mao,Linda S Chan et al.
Shawn Martin et al.
Present day approaches for the determination of protein-protein interaction networks are usually based on two hybrid experimental measurements. Here we consider a computational method that uses another type of experimental data: instead of ...
Pharmacogenomics: analysing SNPs in the CYP2D6 gene using amino acid properties [0.03%]
药基因组学：运用氨基酸属性分析CYP2D6基因的SNP
Mark T W Ebbert,Wesley A Beckstead,Timothy D O&#x;Connor et al.
Mark T W Ebbert et al.
The CYP2D6 gene is responsible for metabolising a large portion of the commonly prescribed drugs. Because of its importance, various approaches have been taken to analyse CYP2D6 and Single Nucleotide Polymorphisms (SNPs) throughout its sequ...
Molecular coevolution of the vertebrate cytochrome c(1) and Rieske iron sulphur protein in the cytochrome bc(1) complex [0.03%]
脊椎动物细胞色素c₁和Rieske铁硫蛋白的分子协同进化在细胞色素bc₁复合物中
Kimberly K Baer,David A McClellan
Kimberly K Baer
Cytochrome c(1) (cyt-c(1)) and the Rieske Iron Sulphur Protein (ISP) are subunits of the cytochrome bc(1) complex located in the mitochondria functioning both as a proton pump and an electron transporter. Vertebrate model organism phylogeni...
Raja Loganantharaj,Vivek Philip
Raja Loganantharaj
A function of a protein is dependent on its structure; therefore, predicting a protein structure from an amino acid sequence is an active area of research. To improve the accuracy of validation of structures, we are studying the predictabil...
Proteomic data mining using predicted peptide chromatographic retention times [0.03%]
基于预测肽保留时间的蛋白质组数据挖掘
Brian Tripet,Megha Renuka Jayadev,Don Blow et al.
Brian Tripet et al.
Correct identification of proteins from peptide fragments is important for proteomic analyses. Peptides are initially separated by Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) before Mass Spectrometry (MS) identification....
Biomedical ontology improves biomedical literature clustering performance: a comparison study [0.03%]
生物医学本体论改善了生物医学文献聚类的性能：一项比较研究
Illhoi Yoo,Xiaohua Hu,Il-Yeol Song
Illhoi Yoo
Document clustering has been used for better document retrieval and text mining. In this paper, we investigate if a biomedical ontology improves biomedical literature clustering performance in terms of the effectiveness and the scalability....
Enhanced semantic access to the protein engineering literature using ontologies populated by text mining [0.03%]
基于文本挖掘的本体在增强蛋白质工程文献语义检索中的作用
Rene Witte,Thomas Kappler,Christopher J O Baker
Rene Witte
The biomedical literature is growing at an ever-increasing rate, which pronounces the need to support scientists with advanced, automated means of accessing knowledge. We investigate a novel approach employing description logics (DL)-based ...
Modelling concepts and database implementation techniques for complex biological data [0.03%]
复杂生物学数据的建模概念及数据库实现技术
Ramez Elmasri,Feng Ji,Jack Fu et al.
Ramez Elmasri et al.
Biological data such as protein structure and function, DNA sequences, and metabolic pathways require conceptual modelling characteristics that are not available in the widely used Entity-Relationship (ER) model and its variants, such as th...
Deendayal Dinakarpandian,Tuanjie Tong,Yugyung Lee
Deendayal Dinakarpandian
There has been a large increase in the number of ontologies that have been introduced by the biomedical community in recent years. To maximise their potential, there is an urgent need for a mechanism to build interoperability between ontolo...