Jia-Ying Joey Lee,Jingtao Zhang,Sin-Chi Chew et al.
Jia-Ying Joey Lee et al.
Bulk high-resolution mass spectrometry provides sensitive and global snapshots of metabolites involved in cancer metabolism. However, intratumoral heterogeneity obscures the cellular origins of detected metabolites, making it difficult to i...
Erik Serrano,John Peters,Jesko Wagner et al.
Erik Serrano et al.
For over two decades, image-based profiling has revolutionized cell phenotype analysis. Image-based profiling processes rich, high-throughput, microscopy data into thousands of unbiased measurements that reveal phenotypic patterns powerful ...
A novel combination therapy for ER+ breast cancer suppresses drug resistance via an evolutionary double-bind [0.03%]
Rena Emond,Jeffrey West,Vince K Grolmusz et al.
Rena Emond et al.
Chemotherapy remains a commonly used and important treatment option for metastatic breast cancer. A majority of Estrogen Receptor-positive (ER + ) metastatic breast cancer patients ultimately develop resistance to chemotherapy, resulting in...
VEFill: accurate and generalizable deep mutational scanning score imputation across protein domains [0.03%]
Polina V Polunina,Wolfgang Maier,Alan F Rubin
Polina V Polunina
Deep Mutational Scanning (DMS) assays can systematically assess the effects of amino acid substitutions on protein function, but many datasets have incomplete variant coverage due to technical constraints. We developed VEFill (Variant Effec...
Rotem Fuchs,Ofir Schor,Bar Naim et al.
Rotem Fuchs et al.
Viral proteins interact with host proteins to hijack cellular pathways important for viral replication. Viral mimics are proteins whose structural similarity to host-mimicked proteins allows them to interact with mutual host targets. This m...
A universal surface functionalization technique to chemically enhance live microbial cells [0.03%]
一种用于化学增强活微生物细胞的通用表面功能化技术
Gabriel T Vercelli,Xingcheng Zhou,Stefany Moreno-Gámez et al.
Gabriel T Vercelli et al.
Microbial surface functionalization is a powerful strategy for endowing microbes with novel, non-genetic functions. However, existing methods are often species-specific, limited in scope, and compromise cell viability. Here, we present a un...
Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies [0.03%]
来源于不同突触核蛋白病的α-突触核蛋白原纤维多态体的结构功能关系
Tetiana Serdiuk,Virginie Redeker,Jimmy Savistchenko et al.
Tetiana Serdiuk et al.
The aggregation of the protein alpha-synuclein (αSyn) is a common feature of multiple neurodegenerative diseases collectively called synucleinopathies, for which the pathobiology is not well understood. The different phenotypic characteris...
Identifying clinically relevant cell state interactions in the tumor microenvironment of IDH-mutant gliomas using CSI-TME [0.03%]
利用CSI-TME识别IDH突变型胶质瘤肿瘤微环境中临床相关的细胞状态相互作用
Arashdeep Singh,Bharati Mehani,Vishaka Gopalan et al.
Arashdeep Singh et al.
Tumor microenvironment (TME) is characterized by a milieu of distinct cell types that exist in heterogenous transcriptional states across tumors. Functional interactions among these cell states drive tumor progression and therapy response. ...
Integrative multi-omics defines melanoma drug response networks and ARID1A-dependent resistance mechanisms [0.03%]
整合多组学定义了黑色素瘤药物反应网络和ARID1A依赖性耐药机制
Charlie George Barker,Sumana Sharma,Ana Mafalda Santos et al.
Charlie George Barker et al.
Resistance to BRAF/MAPK inhibitors is a significant challenge in melanoma treatment, driven by adaptive and acquired mechanisms allowing tumor cells to evade therapy. We explored early signaling responses to BRAF and MAPK inhibition in a BR...
Kevin Drew
Kevin Drew