Co-Occurrence of HIV-Susceptibility and -Protective HLA Alleles Is a Possible Contributor to the Development of Primary HIV-Associated Thrombocytopenia (PHAT): A Cross-Sectional Study [0.03%]
人类白细胞抗原易感和保护型等位基因的共存可能是原发性HIV相关血小板减少症发病机制中的一个促成因素：横断面研究结果
Walter J Janse van Rensburg,Anne-Cecilia van Marle,Lomari Geertsema
Walter J Janse van Rensburg
Primary HIV-associated thrombocytopenia (PHAT) is an isolated thrombocytopenia in HIV-positive individuals in the absence of secondary causes. The presence of certain Human Leukocyte Antigens (HLA) has been linked to individuals' immune res...
The Distribution of HLA-DRB4 Alleles Among HLA-DRB1*07:01-Positive Haplotypes in Saudi Arabia [0.03%]
沙特HLA-DRB1*07:01单体型中HLA-DRB4等位基因的分布情况
Sheerin A Alandejani,Fatma Aytül Uyar,Abdullah Alrasheed et al.
Sheerin A Alandejani et al.
This study investigates the distribution of human leukocyte antigen (HLA)-DRB4 alleles in HLA-DRB1*07:01-positive haplotypes within a Saudi cohort of 313 individuals. It identifies strong linkage disequilibrium between HLA-DRB1*07:01 and sp...
Association Between Pathogenic Variants in NLRP12 and Autoinflammatory Disease: A Comprehensive Systematic Review [0.03%]
NLRP12基因有害变异与自炎症性疾病的相关性：系统评价
Nasimeh Vatandoost,Sajjad Biglari,Tayebeh Ranjbarnejad et al.
Nasimeh Vatandoost et al.
Systemic auto-inflammatory diseases (SAID) are rare inherited conditions characterized by dysregulation of the immune system, which leads to recurrent episodes of fever and systemic inflammation. Recent studies have identified pathogenic va...
Association of HLA-G 14-bp Insertion/Deletion Polymorphism With Recurrent Spontaneous Abortion: A Meta-Analysis [0.03%]
HLA-G IVS1内含子区14bp插入/缺失多态性与复发性自然流产关系的meta分析研究
Yan Sun,Mingzhu Huo,Jihua Zhao et al.
Yan Sun et al.
We performed a meta-analysis to study the relationship between HLA-G 14-bp insertion/deletion polymorphism and recurrent spontaneous abortion (RSA). All literature was searched from PubMed, Web of Science, Embase and Wanfang databases. Stat...
Identification of a Novel Homozygous C1QB Mutation in an Iranian Girl: Expanding the Clinical Spectrum of C1q Deficiency [0.03%]
在一名伊朗女孩中鉴定出一个新的C1QB纯合突变：补充了C1q缺陷的临床特征
Nassim Gorjizadeh,Negar Gorjizadeh,Fatemeh Bitarafan et al.
Nassim Gorjizadeh et al.
C1q deficiency is a rare autosomal recessive disease associated with recurrent skin lesions, chronic infections and an increased risk of autoimmune disorders, particularly systemic lupus erythematosus (SLE) or SLE-like disorders. Additional...
Genetic Variations in TLR2 and TLR4 Genes and Their Association With COVID-19 Severity and Inflammatory Markers in the Moroccan Population [0.03%]
Moroccan人群中的TLR2和TLR4基因多态性及其与COVID-19严重程度和炎症标志物的相关性研究
Rachid Noureddine,Asmaa Haddaji,Hanâ Baba et al.
Rachid Noureddine et al.
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has significantly impacted global health, with Morocco reporting over 1.2 million confirmed cases and more than 16,300 deaths. The severity of COVID-19 varies, ranging from asymptomatic...
Association of Vitamin D Deficiency and Vitamin D Receptor FokI Gene Polymorphism With Diabetic Retinopathy Complications in Ethiopian Patients With Type 2 Diabetes Mellitus [0.03%]
维生素D缺乏和维生素D受体FokI基因多态性与埃塞俄比亚2型糖尿病患者的糖尿病视网膜病变并发症之间的关联
Addisu Melake,Getachew Alamnie,Melaku Mekonnen
Addisu Melake
Several studies suggest that a deficiency in vitamin D might be a potential risk factor for developing diabetic retinopathy. Research has extensively studied vitamin D receptor genes, such as the FokI gene polymorphisms, and found links bet...
HLA-C*01:02 and -C*04:03 May Confer Susceptibility to Treponema pallidum Infection in the Chinese Han Population [0.03%]
中国汉族人群中的HLA-C*01:02和-C*04:03基因型可能增加了感染苍白密螺旋体的易感性
Chen Chen,Fang Wang,Nanying Chen et al.
Chen Chen et al.
Some associations between Treponema pallidum (TP) susceptibility and human leukocyte antigen (HLA) loci at low resolution have been reported. However, the data for TP infection and HLA alleles at high resolution are limited. The purpose of ...
Analysis of Rare Coding Variants in 470,000 UK Biobank Participants Reveals Genetic Associations With Childhood Asthma Predisposition [0.03%]
对47万名英国生物银行参与者中罕见编码变异的分析揭示了与儿童哮喘易感性相关的遗传关联
Zhenzhen Liu,David Curtis
Zhenzhen Liu
Previous studies of genetic contributions to risk of childhood asthma have implicated common variants with small effect sizes. Some studies using exome sequence data have reported associations with rare coding variants having larger effects...
The Quest for Antibodies and Other Acquired Immune Receptors: A Historical Perspective [0.03%]
抗体及其他获得性免疫受体的探寻：历史视角
Andrea De Lerma Barbaro,Sahar Balkhi,Stefano Giovannardi et al.
Andrea De Lerma Barbaro et al.
The diversity of antibody molecules has for decades been an unsolved enigma that has attracted wide interest among biologists. Parallel to the accumulation of experimental evidence, progress in antibody research was also driven by the theor...