Y Kumon,Y Yasuoka,S Yamanaka et al.
Y Kumon et al.
Transthyretin channel formation in lipid membranes: implications for pathogenesis [0.03%]
脂质膜中转运甲状腺素蛋白通道的形成及其病理意义
Y Hirakura,R Azimov,R Azimova et al.
Y Hirakura et al.
Liangping Weng,Brian H Spencer,Pamela T SoohHoo et al.
Liangping Weng et al.
Bone marrow plasma cells (BMPCs) were purified using anti-CD138 immunomagnetic beads, from aspirates obtained with permission of the Boston University Medical Campus Institutional Review Board, from patients with immunoglobulin light chain ...
Antisense oligonucleotide suppression of serum amyloid A reduces amyloid deposition in mice with AA amyloidosis [0.03%]
反义寡核苷酸抑制血清淀粉样蛋白A减少AA型老年痴呆小鼠的淀粉样蛋白沉积
Barbara Kluve-Beckerman,Joyce Hardwick,Lijing Du et al.
Barbara Kluve-Beckerman et al.
AA amyloid patients who experience disease progression and develop renal failure have not received sufficient benefit from agents that treat inflammation or infection. We have begun to explore the potential application of antisense oligonuc...
Pathogenesis of experimental amyloid protein A amyloidosis in sore hocks-affected rabbits [0.03%]
实验性痛爪家兔反应蛋白A淀粉样变性的发病机理研究
Tomoaki Murakami,Yasuo Inoshima,Ken-Ichi Watanabe et al.
Tomoaki Murakami et al.
Although the experimental transmission of amyloid protein A (AA) amyloidosis with amyloid-enhancing factor has been studied intensively, its pathogenesis remains obscure. We previously found that rabbits affected with 'sore hocks' (SH) uniq...
Early diagnosis and management of patients with familial ATTR amyloidosis receiving livers from asymptomatic variant TTR carriers [0.03%]
无症状TTR变异携带者捐赠的肝脏移植ATTR家族性淀粉样变患者早期诊断与管理
Miguel Munar-Qués,Carlos Viader-Farré,José María Zabay-Becerril et al.
Miguel Munar-Qués et al.
The possibility of a patient with familial ATTR amyloidosis receiving a liver from an asymptomatic variant TTR carrier is remote [corrected].However, in 2008, it was reported that this unlikely event occurred in a patient in Portugal. We re...
Michael J Hausmann,Esther Maor,Leonid Kachko
Michael J Hausmann
A 28-year-old women is presented who was evaluated for a new-onset postpartum nephrotic syndrome with normal renal function. Histological diagnosis was AA amyloidosis but no underlying disease has been diagnosed despite extensive workup. Co...
Structural dynamics of the ΔE22 (Osaka) familial Alzheimer's disease-linked amyloid β-protein [0.03%]
与家族性阿尔茨海默病相关的ΔE22（大阪）淀粉样蛋白β蛋白的结构动力学
Mohammed Inayathullah,David B Teplow
Mohammed Inayathullah
A familial form of Alzheimer disease recently was described in a kindred in Osaka, Japan. This kindred possesses an amyloid β-protein (Aβ) precursor mutation within the Aβ coding region that results in the deletion of Glu22 (ΔE22). We r...
The generic amyloid formation inhibition effect of a designed small aromatic β-breaking peptide [0.03%]
一种设计的小芳香β断肽的抗淀粉样蛋白变性通用抑制效应
Anat Frydman-Marom,Ronit Shaltiel-Karyo,Sari Moshe et al.
Anat Frydman-Marom et al.
The development of generic inhibitors in order to control the formation of amyloid fibrils and early oligomers is still an unmet medical need. As it is hypothesized that amyloid assemblies represent a generic protein supramolecular structur...