Rebecca A Hall,Katherine J Baxter
Rebecca A Hall
In nature, microorganisms exist in multispecies microbial communities containing bacteria, fungi, archaea, and viruses. The organisation, behaviour, and ecological impact of these communities are very much defined by the various interaction...
Invasive plasmids as ecosystem engineers-from mechanism to application [0.03%]
侵入性质粒作为生态系统工程师-从机制到应用
Solomon Garland,Victoria T Orr,James P J Hall et al.
Solomon Garland et al.
Horizontal gene transfer, mediated by mobile genetic elements such as conjugative plasmids, is recognised as a major driver of bacterial innovation. While predominantly explored in the context of change within individual strains and species...
From early defence priming to lasting memory: developmental and seasonal dynamics in trees [0.03%]
从早期防御预适应到长期记忆：树木发育和季节动态中的模式
Melissa Mageroy,Estrella Luna,Adriana Puentes
Melissa Mageroy
Defence priming enhances plant responsiveness to future stress following prior exposure, and has been extensively characterised in annual model species as a reversible state associated with faster or stronger defence activation. However, st...
When context matters: community and environmental context to elicit natural products [0.03%]
当环境和背景因素重要时：用于提取天然产物的社区及环境因素
Andres Cumsille,Josephine H I Putnam,Marc G Chevrette
Andres Cumsille
Natural products (NPs) comprise a wide range of bioactive compounds, including therapeutics and antibiotics. Despite several efforts, the discovery of novel NPs has been hindered by frequent rediscoveries of previously known NPs. Computatio...
Amelia Brave,Paul D Straight
Amelia Brave
Streptomycetes are known for their production of diverse secondary metabolites, many of which have medicinal applications. The enzymes facilitating the production of these metabolites are encoded in biosynthetic gene clusters (BGCs) with re...
Translating biosynthetic gene cluster architecture into biosensor design for microbial natural product discovery [0.03%]
基于生物合成基因簇构建微生物天然产物发现的生物传感器设计
Luisa M Trejo-Alarcón,Víctor H Tierrafría,Luis M Salazar-García et al.
Luisa M Trejo-Alarcón et al.
Antimicrobial resistance (AMR) is a growing global health crisis, with mortality already in the millions and projections of up to 10 million deaths annually by 2050. Traditional discovery strategies, such as one strain many compounds-based ...
Saskia E Bakker
Saskia E Bakker
Biofilms are challenging samples for microscopy, because they are usually large samples with small features of interest, a fragile nature due to their high water content, and they may be grown on a variety of substrates. Cryo-scanning elect...
Heterologous expression of NRPS and PKS pathways in Escherichia coli: from bottlenecks to biosynthetic platforms [0.03%]
非核糖体肽合成酶和聚酮合酶途径在大肠杆菌中的异源表达：从瓶颈到生物合成平台
Lisa Göbner,Tobias A M Gulder,Paul M D&#x;Agostino
Lisa Göbner
Microbial natural products (NPs) represent one of the most important sources of bioactive compounds in medicine, agriculture, and biotechnology. Non-ribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) are large multidomain...
A guide to Direct Pathway Cloning (DiPaC) for natural product discovery [0.03%]
直接途径克隆(DiPaC)在天然产物发现中的指南
Lisa Göbner,Roberta R de Castro,Tobias A M Gulder et al.
Lisa Göbner et al.
Natural products (NPs) are a major source of chemical diversity and bioactive molecules. Advances in genome sequencing and bioinformatic analysis have facilitated identification of biosynthetic gene clusters (BGCs) across diverse microorgan...
Expanding perspectives on specialized metabolism in Streptomyces bacteria [0.03%]
streptomyces 细菌专业代谢的视角拓展
Lauren A Tiller,Katharine P McCoy Bridges,Hindra et al.
Lauren A Tiller et al.
Streptomyces bacteria are prodigious producers of specialized metabolites, although when, why, and how they make many of these molecules is a puzzle that scientists have been working to solve for decades. While impressive progress has been ...