Philip Cohen
Philip Cohen
The first protein kinases and their role in cell regulation were identified in the mid-1950s, but it was not until the 1980s that the first inhibitors of these enzymes were developed. More specific inhibitors that suppressed kinase activity...
Plant metabolic adaptation to nitrogen scarcity: the role of biological nitrification inhibitors [0.03%]
植物对氮缺乏的代谢适应：生物硝化抑制剂的作用
Jens Sigurd Agger Raabyemagle,Kasper Hinz,William Thomas Wajn et al.
Jens Sigurd Agger Raabyemagle et al.
In response to soil nitrogen (N) scarcity, plants adapt through physiological plasticity and metabolic strategies that secure and conserve N. Beyond root architecture, microbial symbioses, and allelopathic inhibition of competing plants, ma...
Synthetic microbial communities for studying the fate and ecological role of specialized metabolites [0.03%]
合成微生物群落研究专业代谢物的命运和生态作用
Ákos T Kovács
Ákos T Kovács
A wide range of microbially produced specialized metabolites (SMs) with bioactivity affecting micro- and macro-organisms has been described. These bioactive compounds are synthesized by enzyme complexes encoded in biosynthetic gene clusters...
Christine H Foyer
Christine H Foyer
Plants mastered the art of reduction/oxidation (redox) control early in evolution, incorporating reactive oxygen species (ROS) as ubiquitous 'pioneer' signalling molecules that mediate growth and stress responses. Each compartment of the pl...
How social is social resistance? [0.03%]
Rosie Randall,Ashleigh S Griffin
Rosie Randall
β-lactamases are central to bacterial resistance against β-lactam antibiotics and are often treated as a textbook example of cooperative resistance. The cooperative aspect of their action arises from specific details of their action and l...
Bacterial tryptophan metabolites in cancer and atherosclerosis: insights for a role in immune checkpoint inhibition [0.03%]
色氨酸代谢产物与癌症和动脉粥样硬化中的免疫检查点抑制作用之间的联系
T Dormans,J Kroon,E Rampanelli et al.
T Dormans et al.
The gut microbiota plays a pivotal role in human health, partly through the production of bioactive metabolites from dietary tryptophan. These indole derivatives have emerged as key modulators of immune function, inflammation, and metabolic...
Devanshi Gupta,Subbareddy Maddika
Devanshi Gupta
Ubiquitination is a fundamental post-translational modification that orchestrates a wide range of cellular processes. This modification is executed through a cascade of enzymatic steps involving E1 activating enzymes, E2 conjugating enzymes...
Alex Berretta,Clarissa Schwab
Alex Berretta
The gut microbiome has gained a lot of attention in recent decades due to the multitude of interactions it has with the host. One of the main ways the microbiota communicates with the host is through the fermentation of dietary or host-deri...
Dysbiosis and the gut-brain axis impairment in the pathophysiology of Alzheimer's disease and related dementias: is 'pathobiome' an etiological element? [0.03%]
阿尔茨海默病及相关痴呆症发病机制中的菌群失调和肠-脑轴损伤：是否“致病生物组”是一个病因因素？
Gwoncheol Park,Paramita Chakrabarty,Philip A Efron et al.
Gwoncheol Park et al.
The gut microbiome plays a pivotal role in host metabolic, cardiovascular, and immune health. Increasing evidence also links it to aging-associated neurocognitive decline and neurodegenerative disorders, including Alzheimer's disease (AD) a...
From antibiotic to chalkophore: the biology and evolution of SF2768 in Streptomyces [0.03%]
从抗生素到石素：链霉菌SF2768基因的生物学和进化研究
Kenji Ueda
Kenji Ueda
Copper availability is tightly regulated in microbial environments, yet the diversity and evolutionary origins of copper-chelating metabolites remain poorly understood. SF2768, a diisonitrile compound from Streptomyces, functions both as a ...