Organ and tissue accumulation of titanium dioxide after acute, subacute, subchronic, and chronic oral exposure in mice and rats: a systematic review [0.03%]
口服急性、亚急性、次慢性及慢性暴露后二氧化钛在小鼠和大鼠器官与组织中的蓄积：系统性回顾
Vida Mohammadparast,Jangrez Khan,Penelope Truman et al.
Vida Mohammadparast et al.
Background: Titanium dioxide (TiO2) is a compound that is often used as a white pigment. Commercial TiO2, such as the food additive E171, contains a mix of particle sizes, including a fraction in the nanoscale range (< 10...
Insights into the causal role of diesel exhaust particles in ventricular arrhythmogenesis: protective effects of antioxidant cerium oxide nanoparticles [0.03%]
柴油颗粒对心室颤动发生的因果作用及抗氧化剂纳米氧化铈的保护效应研究
Freddy G Ganse,Lena M Ernst,Cristina Rodríguez et al.
Freddy G Ganse et al.
Background: Epidemiological studies suggest an association between air pollution and ventricular arrhythmias, with reactive oxygen species (ROS) playing a crucial role. However, the causal relationship and long-term effec...
Impact of surface functional group modification on cellular internalization and cytotoxicity of silica nanoparticles [0.03%]
硅基纳米颗粒的表面官能团改性对细胞摄取及毒性的影响
Sandra Vranic,Eri Watanabe,Kyoka Yamazaki et al.
Sandra Vranic et al.
Background: Silica nanoparticles (SiO2NPs) are widely used in industrial products. Surface modification of SiO2NPs is one of the promising strategies to develop safer nanomaterials by design. The present study was designe...
Real-ambient PM2.5 exposure disrupts hematopoietic homeostasis via HIF-1α-driven myeloid skewing and promotes organ inflammation [0.03%]
基于HIF-1α驱动的髓系细胞偏差作用的真实环境PM2.5暴露会破坏造血稳态并促进器官炎症
Hongyan Yu,Yidi Chen,Yuanyuan Wang et al.
Hongyan Yu et al.
Environmental pollutants like PM2.5 threaten hematopoietic homeostasis, yet how real-world exposure disrupts blood cell production, especially locally in the lung and systemically in the bone marrow (BM), remains poorly understood. Previous...
Sleep disruption from inhalation of biomass smoke: a basis for coincident hypertension? [0.03%]
吸入生物质量烟雾引起睡眠中断与高血压的关系？
K M Rentschler,W Kyle Martin,W Oshiro et al.
K M Rentschler et al.
Background: Exposure to air pollution including contemporary sources like wildland fire smoke worsens cardiovascular outcomes. Although several mechanisms for these effects have been postulated, one underexplored impact o...
Inhalation toxicity of arsenic-containing mine dust in an air-liquid interface bronchial epithelial model [0.03%]
含砷矿尘的吸入毒性研究：一种空气-液界面气管上皮模型的方法学探索
Xiaoli Ji,Yanping Li,Shuyi Gu et al.
Xiaoli Ji et al.
Background: Tin mine dust (MD), a by-product of tin mining and rock drilling, is a significant contributor to miners' pneumoconiosis. This aerosolized dust is a complex mixture of mineral components, including potentially...
Fiber length and shape-dependent differences in hepatic nanomaterial localization in mice following pulmonary exposure [0.03%]
基于肺部暴露的纤维长度和形状差异导致的小鼠肝内纳米材料定位分布不同
Mathilde Sundberg,Trine Berthing,Pernille Høgh Danielsen et al.
Mathilde Sundberg et al.
Background: Inhaled nanomaterials can translocate from the lungs into systemic circulation and reach the liver, which is the main secondary organ for nanomaterial uptake, potentially causing adverse effects. Understanding...
Inhibition of protease-activated receptor-2 attenuates multi-walled carbon nanotube exacerbation of allergic lung disease in mice [0.03%]
蛋白酶激活受体-2的抑制作用可减轻多壁碳纳米管加重小鼠过敏性肺病的现象
Logan J Tisch,Ryan D Bartone,Silvio Antoniak et al.
Logan J Tisch et al.
Background: Our previous work showed that exposure to multi-walled carbon nanotubes (MWCNTs) exacerbates allergic lung disease in mice induced by house dust mite extract (HDME). Furthermore, mice genetically deficient in ...
Renal transcriptome-wide analyses in association with kidney black carbon load [0.03%]
与肾脏黑碳负荷相关的肾转录组分析
Leen Rasking,Jasper Callemeyn,Congrong Wang et al.
Leen Rasking et al.
Rationale and objective: Inhaled black carbon (BC) has been previously shown to reach and accumulate in the kidneys. As kidneys filter toxicants, they may be susceptible to adverse effects caused by BC accumulation. We st...
A systematic review of the potential neurotoxicity of micro-and nanoplastics: the known and unknown [0.03%]
微塑料和纳米塑料潜在神经毒性的系统评价：已知与未知
Kinga Vojnits,Andrés de León,Julien Gibon et al.
Kinga Vojnits et al.
Background: The escalating accumulation of micro- and nanoplastics (MNPs) in the environment has raised significant concerns regarding their neurotoxic potential in vertebrates. This critical review synthesizes evidence f...