Pulmonary toxicity of micro- and nano polyethylene particles following intratracheal instillation in rats [0.03%]
经气管内给药后小鼠和纳米大小的聚乙烯颗粒在大鼠肺中的毒性作用研究
Hyoung-Yun Han,Seonae Hwangbo,Eun-Jung Park et al.
Hyoung-Yun Han et al.
Background: Micro- and nano-sized polyethylene plastics (PE-MPs and PE-NPs) are emerging as potential risk factors for pulmonary disease and risk assessment. Currently, their is no direct evidence suggests this appreciabl...
Degradation reshapes the toxic identity of polylactic acid microplastics through MSR1-dependent immune decoding in mouse kidney [0.03%]
降解通过依赖MSR1的免疫解码重塑小鼠肾脏中聚乳酸微塑料的毒性身份
Xiaoqing Chen,Yanhong Deng,Xiyun Huang et al.
Xiaoqing Chen et al.
Background: Biodegradable plastics are increasingly being used as a sustainable alternative, but their degradation in biological environments may produce transformation products with unexpected toxicological characteristi...
Inhalation exposure to surrogate military burn pit emissions impairs systemic microvascular function: linking pulmonary insult and diverse peripheral responses [0.03%]
吸入军事替代燃烧坑排放物的暴露会损害全身微血管功能：肺损伤与周围多种反应之间的联系
Van Nguyen,Anand Ranpara,William T Goldsmith et al.
Van Nguyen et al.
Millions of U.S. troops and supporting personnel have been deployed to military bases in the Middle East. Essentially all personnel on military bases were exposed to the combustion emissions generated by open pit waste burning. Chronic mult...
Bronchial mucosal nuclear transcription factor expression and inflammatory response in humans after exposure to wood smoke [0.03%]
木材烟雾暴露后的人类支气管粘膜核转录因子表达及炎症反应
Alva Hansson,Maria Friberg,Gregory Rankin et al.
Alva Hansson et al.
Background: Exposure to wood smoke is associated with negative respiratory health outcomes such as airway infections and development of chronic obstructive pulmonary disease (COPD). Previous controlled exposure studies in...
Randomized Controlled Trial
Particle and fibre toxicology. 2026 Jun 12;23(1):32. DOI:10.1186/s12989-026-00685-6 2026
Surface-driven endocrine activity of nanoplastics: polymer- and size-dependent estrogen and androgen receptors modulation without steroidogenesis perturbation [0.03%]
纳米塑料的表面驱动内分泌活性：独立于类固醇生成扰动的聚合物和尺寸依赖型雌激素和雄激素受体调节作用
Nikolina Peranić,Lucija Božičević,Nikolina Kalčec et al.
Nikolina Peranić et al.
Growing production and use of plastics have led to significant environmental pollution including the formation and accumulation of plastic nanoparticles (PNPs). Due to their small size, PNPs easily enter the human food chain; however, human...
Oxidative aging facilitates biological barrier penetration of polyethylene microplastics, amplifying systemic lipotoxicity in aquatic species [0.03%]
氧化老化促进聚乙烯微塑料在水生生物体内的生物屏障穿透，加剧其体内脂毒性效应
Yejin Kim,Hyerin Lee,Eunji Lee et al.
Yejin Kim et al.
Background: Environmental aging processes, such as oxidation, can substantially modify the physicochemical properties and toxicity of microplastics (MPs). Nevertheless, most studies have focused on pristine MPs, overlooki...
Targeting the PPAR-γ-ABC transporter axis ameliorates secondary pulmonary alveolar proteinosis induced by indium oxide nanoparticles [0.03%]
靶向PPAR-γ-ABC转运体轴可缓解氧化铟纳米粒子引起的继发性肺泡蛋白沉积症
Soyeon Jeon,Gyuri Kim,Wan-Seob Cho
Soyeon Jeon
Background: Pulmonary alveolar proteinosis (PAP) is a rare lung disease with primary (usually autoimmune) and secondary forms. Unlike the autoimmune type, which can be treated with cytokine therapy or whole-lung lavage, t...
Repeated air pollution exposure predisposes to adverse outcomes from acute lung injury [0.03%]
反复接触空气污染易导致肺损伤后的不良预后
Chiara Monge,Nairrita Majumder,Ian Cumming et al.
Chiara Monge et al.
Background: Air pollution exposure is associated with increased risk of developing acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). While the possibility of air pollution priming the immune system t...
Cu(OH)2 nanopesticide triggered heart failure-like pathogenesis in mice by potentially targeting mmu-miRNA-590-3p and mmu-miRNA-338-5p in Wnt/β-catenin signaling [0.03%]
Cu(OH)₂纳米农药通过潜在靶向Wnt/β-catenin信号传导中的mmu-miRNA-590-3p和mmu-miRNA-338-5p在小鼠中引发类似心力衰竭的发病机制
Zhihua Ren,Yixue Cai,Yonghui Duan et al.
Zhihua Ren et al.
Background: Nanopesticides have been progressively incorporated into contemporary agricultural systems owing to their distinctive physicochemical characteristics and superior pest management capabilities. Given their envi...
Pulmonary toxicity of brake wear particles: effects of composition and surface reactivity [0.03%]
制动磨损颗粒的肺毒性：组成和表面反应性的影响
Gyuri Kim,Soyeon Jeon,Tae Hwan Shin et al.
Gyuri Kim et al.
Background: Airborne brake wear particles (BWPs) are increasingly recognized as important non-exhaust contributors to urban particulate pollution; however, their inhalation toxicity and the key determinants of their pulmo...