Gut-ovary axis mediated synergistic reproductive toxicity of polystyrene nanoplastics and perfluorobutanoic acid co-exposure: pyroptotic signaling and probiotic mitigation [0.03%]
聚苯乙烯纳米塑料和全氟丁酸共暴露介导的肠道-卵巢轴协同生殖毒性：焦亡信号与益生菌缓解作用
Jialyu Huang,Yiwei Zhang,Penghui Nie et al.
Jialyu Huang et al.
Polystyrene nanoplastics (PS-NPLs) and perfluorobutanoic acid (PFBA) are pervasive contaminants of great concern and can enter human body primarily through gastrointestinal tract. However, their single and combined effects on female reprodu...
Alignment of in vitro and in vivo pulmonary inflammation models using crystalline quartz silica [0.03%]
利用结晶二氧化硅对体外和体内肺部炎症模型进行校准
Isidora Loncarevic,Seyran Mutlu,Martina Dzepic et al.
Isidora Loncarevic et al.
Background: Systematic in vitro-in vivo comparisons are increasingly used to assess the relevance and predictivity of in vitro lung models for inhalation toxicology and regulatory risk assessment. Here, we compared inflam...
A comparative biodistribution and toxicity study of single and multi-component nanomaterials: NMs: TiO2, SiC, and SiC@TiO2 [0.03%]
单组分和多组分纳米材料：TiO₂、SiC和SiC@TiO₂的生物分布与毒性比较研究
Wenting Zhang,Muhammad Daniyal Ghouri,Magda Blosi et al.
Wenting Zhang et al.
Supplemental exposure to polystyrene nanoplastics synergistically amplifies calcium oxalate crystal-induced injury to renal tubular epithelium, accelerating the formation of calcium oxalate kidney stones [0.03%]
聚苯乙烯纳米塑料的补充暴露与钙氧盐晶体协同作用，加剧对肾小管上皮细胞的损伤，并加速钙氧盐肾结石的形成
Xiaozhe Su,Yijun Yang,Heng Xiang et al.
Xiaozhe Su et al.
Background: With the escalating issue of polystyrene microplastic pollution, microplastic particles have been detected in human urine. While calcium oxalate (CaOx) crystals are well-established mediators of renal stone fo...
Susceptibility to systemic autoimmunity rather than the presence of the HLA-DR4 peptide binding domain alone leads to severe inflammatory arthritis following inhalation of crystalline silica [0.03%]
易患系统性自身免疫而不是存在HLA-DR4肽结合域独自导致吸入结晶二氧化硅后出现严重的炎性关节炎
Lisa M F Janssen,Caroline de Ocampo,Dwight H Kono et al.
Lisa M F Janssen et al.
Background: The mucosal origins hypothesis of rheumatoid arthritis (RA) posits that inhalant exposures, such as cigarette smoke and crystalline silica (c-silica), trigger immune responses in the lungs that contribute to j...
Anna Wagner,Florian Schulz,Asmus Meyer-Plath et al.
Anna Wagner et al.
Background: Carbon based fibers are considered to exhibit a carcinogenic potency when inhaled into the deep lung. Mesotheliomas develop after intraperitoneal application of multi-walled carbon nanotubes (MWCNTs) exceeding...
Lung retention, distribution and persistence of polymer particles in rats exposed via inhalation [0.03%]
大鼠经气管给药后肺部聚合颗粒的滞留、分布及持续时间研究
Emanoela Thá,Lan Ma-Hock,Markus Rueckel et al.
Emanoela Thá et al.
Background: Microplastics have been repeatedly detected in the human body, yet uncertainties surround their bioavailability and fate due to experimental challenges and limitations, especially regarding their nano-sized co...
Modulatory effects of CeO2 nanoparticles on bleomycin-induced active pulmonary disease processes in animal and human airway epithelium models [0.03%]
CeO2纳米颗粒对动物和人呼吸道上皮模型中博莱霉素诱导的主动肺病过程的调节作用
Chang Guo,Alison Buckley,Sarah Robertson et al.
Chang Guo et al.
Background: Understanding the impacts of inhaled insoluble nanomaterials as they are encountered in the environment and workplace, in injured lungs remains limited, particularly with respect to their role in the progressi...
Particulate matter 2.5 promotes bladder cancer cell migration and invasion through the crosstalk between integrin-mediated MAPK/ERK and Wnt/β-catenin pathways [0.03%]
颗粒物通过整合素介导的MAPK / ERK和Wnt / β-连锁蛋白途径交叉谈促进膀胱癌细胞迁移和侵袭2.5
Yung-Ting Cheng,Kai-Hsi Lu,Shu-Ying Hong et al.
Yung-Ting Cheng et al.
Background: Fine particulate matter 2.5 (PM2.5), a key indicator of air pollution, is classified as a human carcinogen. However, the link between air pollution and bladder cancer (BC) progression remains unclear. Dysregul...
Inhalation toxicity, pulmonary clearance, and biotransformation of ferric oxide nanoparticles in rats [0.03%]
纳米四氧化三铁粒子的吸入毒性、肺清除和生物转化作用研究
Songyeon Kim,Jiyoung Jeong,Seunghan Lee et al.
Songyeon Kim et al.
Background: Ferric oxide (Fe2O3) nanoparticles are widely used in industrial and biomedical applications, raising concerns regarding inhalation exposure, particularly in occupational settings. Although the inhalation toxi...