Maternal exposure to titanium dioxide nanoparticles disrupts ultrasonic vocalization development in mouse offspring [0.03%]
妊娠期母鼠暴露于二氧化钛纳米粒子可影响子代超声通讯能力的发展
Marie Boulain,Taner Aktas,Gilles Courtand et al.
Marie Boulain et al.
Background: Early neurodevelopment is a critical period during which environmental exposures can have lasting effects on brain function and behavior. One key indicator of early neurodevelopmental integrity in rodents is t...
A comprehensive review on the role of PM2.5 in modulating transplant immunity and graft survival [0.03%]
PM2.5对调控移植免疫和移植物存活作用的研究进展综合述评
Muhammad Adil Malik,Quan Zhuang,Junjie Huang et al.
Muhammad Adil Malik et al.
Organ transplantation is an indispensable therapeutic approach for patients experiencing end-stage organ failure. Despite ongoing advancements and refinements in immunosuppressive therapies aimed at mitigating graft rejection and enhancing ...
Maternal PM2.5 exposure induces insulin resistance in adult male mouse offspring via gut-liver axis [0.03%]
母体PM2.5暴露通过肠道-肝脏轴诱导雄性小鼠后代成年期胰岛素抵抗
Renjie Hu,Wenbin Zhao,Wenjun Fan et al.
Renjie Hu et al.
Background: The rising prevalence of metabolic diseases represents a global health challenge, with metabolically unhealthy normal-weight (MUHNW) individuals remaining largely overlooked. In addition to direct fine particu...
Small particles, large questions: unravelling the toxicity and potential health risks of PET micro-/nanoplastics [0.03%]
大小颗粒，大问题：解开PET微/纳米塑料的毒性及其潜在健康风险
Michaela Hanzlova,Drahomira Holmannova,Tereza Svadlakova et al.
Michaela Hanzlova et al.
Despite the extensive use of polyethylene terephthalate (PET), the public health implications of its micro- and nanoparticles (MNPs) remain poorly understood, raising credible concerns about human exposure and health risks. We conducted a c...
Macrophages bend long fibres with flexural rigidity lower than 3 mN·nm2 to avoid frustrated phagocytosis [0.03%]
巨噬细胞如何弯曲柔度小于3毫牛顿·纳米的长纤维以避免受挫吞噬作用
Dirk Broßell,Asmus Meyer-Plath,Oliver Gräb et al.
Dirk Broßell et al.
Background: It is an established toxicological principle that the inhalation pathogenicity of respirable and biodurable fibres is caused by excessive fibre length as alveolar macrophages fail to uptake and remove such fib...
Lan Ma-Hock,Heidi Stratmann,Matthias Hufnagel et al.
Lan Ma-Hock et al.
Poorly soluble low toxicity particles (PSLT) have long been a concept in particle toxicology and regulatory frameworks addressing inhalation hazards. The term PSLT refers to particles that exhibit low toxicity and minimal solubility in biol...
The effects of ingested cellulose nanomaterials on DNA methylation in intestinal cells [0.03%]
口服摄入的纤维素纳米材料对肠细胞DNA甲基化的影响
Nádia Vital,Célia Ventura,Camila Fernandes et al.
Nádia Vital et al.
Background: Cellulose nanomaterials (CNMs) are emerging materials under development for various applications in biomedicine and the food industry. Consequently, their potential human health effects warrant evaluation, par...
Inhibition of PADI2-mediated vimentin citrullination alleviates silica-induced pulmonary fibrosis in mice [0.03%]
PADI2介导的波形蛋白脱氨基化抑制缓解小鼠硅肺纤维化
Fuyu Jin,Yaqian Li,Tian Li et al.
Fuyu Jin et al.
Silicosis remains a critical occupational health concern worldwide, lacking effective treatments due to unclear mechanisms. In this study, we investigated the citrullinated proteomic profile and its effects in mice exposed to silica. Our fi...
Associations of prenatal fine particulate matter mixtures with neurodevelopmental outcomes in early childhood: component- and source-specific insights [0.03%]
孕期细颗粒物混合暴露与儿童早期神经发育结局关联：组分及来源解析
Haonan Li,Elizabeth A Holzhausen,Devendra Paudel et al.
Haonan Li et al.
Emerging cardiovascular risks of micro- and nanoplastics: toxic effects and mechanistic pathways [0.03%]
微塑料和纳米塑料的心血管新兴风险：毒性作用及机制途径
Gang Liu,Qiuya Cai,Tingchen Qin et al.
Gang Liu et al.
Micro- and nanoplastics (MNPs), due to their widespread distribution and chemical stability, have emerged as novel environmental contaminants threatening cardiovascular health. Evidence links MNPs to conditions such as atherosclerosis, card...